Browsing NTNU Open by Author "Giambelluca, Miriam"
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Autophagy in tissues and solid tumors controlled by infiltrating immune cells
Lamsal, Apsana (Doctoral theses at NTNU;2023:189, Doctoral thesis, 2023)Nye angrepspunkter for målrettet behandling av aggressiv kreft Brystkreft er en av de mest utbredte kreftformene og vi har i dag gode behandlingsformer. Hos noen brystkreftpasienter vil likevel kreftceller sprer seg ... -
Coactivation of TLR2 and TLR8 in Primary Human Monocytes Triggers a Distinct Inflammatory Signaling Response
Bösl, Korbinian; Giambelluca, Miriam; Haug, Markus; Bugge, Marit; Espevik, Terje; Kandasamy, Richard Kumaran; Bergstrøm, Bjarte Aune (Journal article; Peer reviewed, 2018)Innate immune signaling is essential to mount a fast and specific immune response to pathogens. Monocytes and macrophages are essential cells in the early response in their capacity as ubiquitous phagocytic cells. They ... -
TLR8 and complement C5 induce cytokine release and thrombin activation in human whole blood challenged with Gram-positive bacteria
Ehrnstrøm, Birgitta; Kojen, June Frengen; Giambelluca, Miriam; Ryan, Liv; Moen, Siv Helen; Hu, Zhenyi; Yin, Hang; Mollnes, Tom Eirik; Damås, Jan Kristian; Espevik, Terje; Stenvik, Jørgen (Journal article; Peer reviewed, 2020)We recently showed that TLR8 is critical for the detection of Gram‐positive bacteria by human monocytes. Here, we hypothesized that TLR8 and complement together regulate antibacterial responses in human blood. Anticoagulated ... -
UMP-CMP kinase 2 gene expression in macrophages is dependent on the IRF3-IFNAR signaling axis
Kim, Hera; Subbannayya, Yashwanth; Humphries, Fiachra; Skjesol, Astrid; Pinto, Sneha M.; Giambelluca, Miriam; Espevik, Terje; Fitzgerald, Katherine A.; Kandasamy, Richard Kumaran (Peer reviewed; Journal article, 2021)Toll-like receptors (TLRs) are highly-conserved pattern recognition receptors that mediate innate immune responses to invading pathogens and endogenous danger signals released from damaged and dying cells. Activation of ...