• Alginate Microsphere Encapsulation of Drug-Loaded Nanoparticles: A Novel Strategy for Intraperitoneal Drug Delivery 

      Fleten, Karianne Giller; Hyldbakk, Astrid; Einen, Caroline; Benjakul, Sopisa; Strand, Berit Løkensgard; Davies, Catharina de Lange; Mørch, Ýrr Asbjørg; Flatmark, Kjersti (Peer reviewed; Journal article, 2022)
      Alginate hydrogels have been broadly investigated for use in medical applications due to their biocompatibility and the possibility to encapsulate cells, proteins, and drugs. In the treatment of peritoneal metastasis, rapid ...
    • Cabazitaxel-loaded Poly(2-ethylbutyl cyanoacrylate) nanoparticles improve treatment efficacy in a patient derived breast cancer xenograft 

      Fusser, Markus; Øverbye, Anders; Pandya, Abhilash D.; Mørch, Ýrr Asbjørg; Borgos, Sven Even F.; Kildal, Wanja; Snipstad, Sofie; Sulheim, Einar; Fleten, Karianne Giller; Askautrud, Hanne Arenberg; Engebraaten, Olav; Flatmark, Kjersti; Iversen, Tore Geir; Sandvig, Kirsten; Skotland, Tore; Mælandsmo, Gunhild Mari (Journal article; Peer reviewed, 2018)
      The effect of poly(2-ethyl-butyl cyanoacrylate) nanoparticles containing the cytotoxic drug cabazitaxel was studied in three breast cancer cell lines and one basal-like patient-derived xenograft model grown in the mammary ...
    • Circulating Exosomal miR-141-3p and miR-375 in Metastatic Progression of Rectal Cancer 

      Meltzer, Sebastian; Bjørnetrø, Tonje; Lyckander, Lars Gustav; Flatmark, Kjersti; Dueland, Svein; Samiappan, Rampradeep; Johansen, Christin; Kalanxhi, Ert; Ree, Anne Hansen; Redalen, Kathrine (Journal article; Peer reviewed, 2019)
      As many as 30% to 40% of locally advanced rectal cancer (LARC) patients experience metastatic progression of the disease. Recognizing the potential of the genetic cargo in tumor-derived exosomes, we hypothesized that plasma ...
    • The circulating soluble form of the CD40 costimulatory immune checkpoint receptor and liver metastasis risk in rectal cancer 

      Meltzer, Sebastian; Kristensen, Annette Torgunrud; Abrahamsson, Hanna Josefine; Solbakken, Arne Mide; Flatmark, Kjersti; Dueland, Svein; Bakke, Kine Mari; Bousquet, Paula; Negård, Anne; Johansen, Christin; Lyckander, Lars Gustav; Larsen, Finn Ole; Schou, Jakob Vasehus; Redalen, Kathrine; Ree, Anne Hansen (Peer reviewed; Journal article, 2021)
      Background In colorectal cancer, the inflamed tumour microenvironment with its angiogenic activities is immune- tolerant and incites progression to liver metastasis. We hypothesised that angiogenic and inflammatory factors ...
    • Corrigendum to “Circulating exosomal miR-141-3p and miR-375 in metastatic progression of rectal cancer” [Transl Oncol 12 (8) (2019) 1038-1044] 

      Meltzer, Sebastian; Bjørnetrø, Tonje; Lyckander, Lars Gustav; Flatmark, Kjersti; Dueland, Svein; Samiappan, Rampradeep; Johansen, Christin; Kalanxhi, Erta; Ree, Anne Hansen; Redalen, Kathrine (Peer reviewed; Journal article, 2020)
    • Diffusion-weighted magnetic resonance imaging of rectal cancer: tumour volume and perfusion fraction predict chemoradiotherapy response and survival 

      Bakke, Kine Mari; Hole, Knut Håkon; Dueland, Svein; Kotanska-Grøholt, Krystyna; Flatmark, Kjersti; Ree, Anne Hansen; Seierstad, Therese; Redalen, Kathrine Røe (Journal article, 2017)
      Background: In locally advanced rectal cancer (LARC), responses to preoperative treatment are highly heterogeneous and more accurate diagnostics are likely to enable more individualised treatment approaches with improved ...
    • Early radiologic signal of responsiveness to immune checkpoint blockade in microsatellite-stable/mismatch repair-proficient metastatic colorectal cancer 

      Meltzer, Sebastian; Negård, Anne; Bakke, Kine Mari; Hamre, Hanne Mari; Kersten, Christian; Hofsli, Eva; Guren, Marianne; Sorbye, Halfdan; Flatmark, Kjersti; Ree, Anne Hansen (Journal article; Peer reviewed, 2022)
    • High level of circulating vitamin D during neoadjuvant therapy may lower risk of metastatic progression in high-risk rectal cancer 

      Abrahamsson, Hanna Josefine; Porojnicu, Alina Carmen; Lindstrøm, Jonas Christoffer; Dueland, Svein; Flatmark, Kjersti; Hole, Knut Håkon; Seierstad, Therese; Moan, Johan Emilian; Redalen, Kathrine; Meltzer, Sebastian; Ree, Anne Hansen (Journal article; Peer reviewed, 2019)
      Background:Following curative-intent neoadjuvant therapy in locally advanced rectal cancer, metastaticprogression is still dominant. We investigated if patients’circulating 25-hydroxyvitamin D [25(OH)D] levels wereassociated ...
    • High level of circulating vitamin D during neoadjuvant therapy may lower risk of metastatic progression in high-risk rectal cancer 

      Abrahamsson, Hanna Josefine; Porojnicu, Alina Carmen; Lindstrøm, Jonas Christoffer; Dueland, Svein; Flatmark, Kjersti; Hole, Knut Håkon; Seierstad, Therese; Moan, Johan Emilian; Redalen, Kathrine Røe; Meltzer, Sebastian; Ree, Anne Hansen (Journal article; Peer reviewed, 2019)
      Background: Following curative-intent neoadjuvant therapy in locally advanced rectal cancer, metastatic progression is still dominant. We investigated if patients’ circulating 25-hydroxyvitamin D [25(OH)D] levels were ...
    • Immunogenic cell death by neoadjuvant oxaliplatin and radiation protects against metastatic failure in high-risk rectal cancer. 

      Bains, Simer Jit; Abrahamsson, Hanna Josefine; Flatmark, Kjersti; Dueland, Svein; Hole, Knut Håkon; Seierstad, Therese; Redalen, Kathrine; Meltzer, Sebastian; Ree, Anne Hansen (Journal article; Peer reviewed, 2019)
      Objective High rates of systemic failure in locally advanced rectal cancer call for a rational use of conventional therapies to foster tumor-defeating immunity. Methods We analyzed the high-mobility group box-1 ...
    • Impact of KRAS, BRAF and microsatellite instability status after cytoreductive surgery and HIPEC in a national cohort of colorectal peritoneal metastasis patients 

      Larsen, Stein Gunnar; Goscinski, Mariusz Adam; Dueland, Svein; Steigen, Sonja Eriksson; Hofsli, Eva; Torgunrud, A.; Lund-Iversen, Marius; Dagenborg, Vegar Johansen; Flatmark, Kjersti; Sorbye, Halfdan (Peer reviewed; Journal article, 2021)
      Patients with metastatic colorectal cancer (mCRC) carrying BRAF (mutBRAF) or KRAS mutation (mutKRAS) have an inferior prognosis after liver or lung surgery, whereas the prognostic role in the context of peritoneal metastasis ...
    • Increased Local Inflammatory Response to MOC31PE Immunotoxin After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy 

      Thorgersen, Ebbe Billmann; Asvall, Jørund; Frøysnes, Ida Storhaug; Schjalm, Camilla; Larsen, Stein Gunnar; Dueland, Svein; Andersson, Yvonne; Fodstad, Øystein; Mollnes, Tom Eirik; Flatmark, Kjersti (Journal article; Peer reviewed, 2021)
      Background - Despite extensive cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC), most patients with resectable peritoneal metastases from colorectal cancer experience disease relapse. MOC31PE ...
    • Intraperitoneal administration of cabazitaxel-loaded nanoparticles in peritoneal metastasis models 

      Hyldbakk, Astrid; Fleten, Karianne Giller; Snipstad, Sofie; Åslund, Andreas; Davies, Catharina de Lange; Flatmark, Kjersti; Mørch, Ýrr Asbjørg (Peer reviewed; Journal article, 2023)
      Colorectal and ovarian cancers frequently develop peritoneal metastases with few treatment options. Intraperitoneal chemotherapy has shown promising therapeutic effects, but is limited by rapid drug clearance and systemic ...
    • Long-term oncologic outcomes after laparoscopic versus open resection for colorectal liver metastasis 

      Aghayan, Davit; Kazaryan, Airazat; Dagenborg, Vegar Johansen; Røsok, Bård Ingvald; Fagerland, Morten Wang; Bjørnelv, Gudrun Maria Waaler; Kristiansen, Ronny; Flatmark, Kjersti; Fretland, Åsmund Avdem; Edwin, Bjørn (Peer reviewed; Journal article, 2020)
      Background: Despite the recent worldwide dissemination of laparoscopic liver surgery, no high-level evidence supports the oncologic safety of this approach. Objective: To evaluate long-term oncologic outcomes after ...
    • Markers of mitochondrial metabolism in tumor hypoxia, systemic inflammation, and adverse outcome of rectal cancer 

      Bousquet, Paula; Meltzer, Sebastian; Sønstevold, Linda; Esbensen, Qin Ying; Dueland, Svein; Flatmark, Kjersti; Sitter, Beathe; Bathen, Tone Frost; Seierstad, Therese; Redalen, Kathrine; Eide, Lars; Ree, Anne Hansen (Journal article; Peer reviewed, 2019)
      Tumor hypoxia contributes to therapy resistance and metastatic progression of locally advanced rectal cancer (LARC). We postulated that the tumor mitochondrial metabolism, manifested by reactive oxygen species (ROS) and ...
    • MRI-based automatic segmentation of rectal cancer using 2D U-Net on two independent cohorts 

      Knuth, Franziska Hanna; Adde, Ingvild Askim; Huynh, Bao Ngoc; Grøndahl, Aurora Rosvoll; Winter, René; Negård, Anne; Holmedal, Stein Harald; Meltzer, Sebastian; Ree, Anne Hansen; Flatmark, Kjersti; Dueland, Svein; Hole, Knut Håkon; Seierstad, Therese; Redalen, Kathrine; Futsæther, Cecilia Marie (Peer reviewed; Journal article, 2021)
      Background Tumor delineation is time- and labor-intensive and prone to inter- and intraobserver variations. Magnetic resonance imaging (MRI) provides good soft tissue contrast, and functional MRI captures tissue properties ...
    • MRI-based automatic segmentation of rectal cancer using 2D U-Net on two independent cohorts 

      Knuth, Franziska Hanna; Adde, Ingvild Askim; Huynh, Bao Ngoc; Groendahl, Aurora Rosvoll; Winter, René Mario; Negård, Anne; Holmedal, Stein Harald; Meltzer, Sebastian; Ree, Anne Hansen; Flatmark, Kjersti; Dueland, Svein; Hole, Knut Håkon; Seierstad, Therese; Redalen, Kathrine Røe; Futsaether, Cecilie Maria (Peer reviewed; Journal article, 2022)
      Background: Tumor delineation is time- and labor-intensive and prone to inter- and intraobserver variations. Magnetic resonance imaging (MRI) provides good soft tissue contrast, and functional MRI captures tissue properties ...
    • Perioperative management and anaesthetic considerations in pelvic exenterations using Delphi methodology: results from the PelvEx Collaborative 

      Chok, Aik Yong; Oliver, A; Rasheed, S; Tan, E J; Kelly, M E; Aalbers, A G J; Abdul Aziz, N; Abecasis, N; Nordling, Mirna Abraham; Akiyoshi, T; Alberda, W; Albert, M; Andric, M; Angenete, Eva; Antoniou, A; Auer, R; Austin, K K; Aziz, O; Baker, R P; Bali, M; Baseckas, G; Bebington, B; Bedford, M; Bednarski, B K; Beets, G L; Berg, P L; Beynon, John; Biondo, S; Boyle, K; Bordeianou, L; Bremers, A B; Brunner, M; Buchwald, Pamela; Bui, A; Burgess, A; Burger, J W A; Burling, David; Burns, E; Campain, N; Carvahal, S; Castro, L; Caycedo-Marulanda, A; Chan, K K L; Chang, G J; Chew, M H; Chong, P; Christensen, Henrik K.; Clouston, H; Codd, M; Collins, D; Flatmark, Kjersti; Larsen, Stein Gunnar; Wasmuth, Hans (Peer reviewed; Journal article, 2021)
      Background The multidisciplinary perioperative and anaesthetic management of patients undergoing pelvic exenteration is essential for good surgical outcomes. No clear guidelines have been established, and there is wide ...
    • Sex-related differences in primary metastatic site in rectal cancer; associated with hemodynamic factors? 

      Meltzer, Sebastian; Bakke, Kine Mari; Rød, Karina Lund; Negård, Anne; Flatmark, Kjersti; Solbakken, Arne Mide; Kristensen, Annette Torgunrud; Fuglestad, Anniken Jørlo; Kersten, Christian; Dueland, Svein; Seierstad, Therese; Hole, Knut Håkon; Lyckander, Lars Gustav; Larsen, Finn Ole; Schou, Jakob Vasehus; Brown, Dawn; Abrahamsson, Hanna Josefine; Redalen, Kathrine; Ree, Anne Hansen (Journal article; Peer reviewed, 2019)
      Background and purpose We investigated how features relating to pelvic cavity anatomy and tumor hemodynamic factors may influence systemic failure in rectal cancer. Materials and methods Rectal cancer patients (207 ...
    • Systemic immune response induced by oxaliplatin-based neoadjuvant therapy favours survival without metastatic progression in high-risk rectal cancer 

      Kalanxhi, Ert; Meltzer, Sebastian; Schou, Jakob Vasehus; Larsen, Finn Ole; Dueland, Svein; Flatmark, Kjersti; Jensen, Benny Vittrup; Hole, Knut Håkon; Seierstad, Therese; Redalen, Kathrine; Nielsen, Dorte Lisbet; Ree, Anne Hansen (Journal article; Peer reviewed, 2018)
      Background Systemic failure remains a challenge in rectal cancer. We investigated the possible systemic anti-tumour immune activity invoked within oxaliplatin-based neoadjuvant therapy. Methods In two high-risk patient ...