• Cumulative prognostic score predicting mortality in patients older than 80 years admitted to the ICU 

      de Lange, Dylan W.; Brinkman, Sylvia; Flaatten, Hans; Boumendil, Ariane; Morandi, Alessandro; Andersen, Finn Husøy; Artigas, Antonio; Bertolini, Guido; Cecconi, Maurizio; Christensen, Steffen; Faraldi, Loredana; Fjølner, Jesper; Jung, Christian; Marsh, Brian; Moreno, Rui; Oeyen, Sandra; Öhman, Christina Agwald; Bollen Pinto, Bernardo; de Smet, Anne Marie G.A.; Soliman, Ivo W.; Szczeklik, Wojciech; Valentin, Andreas; Watson, Ximena; Zafeiridis, Tilemachos; Guidet, Bertrand (Journal article; Peer reviewed, 2019)
      OBJECTIVES To develop a scoring system model that predicts mortality within 30 days of admission of patients older than 80 years admitted to intensive care units (ICUs). DESIGN Prospective cohort study. SETTING A total ...
    • Early diagnosis of sepsis in emergency departments, time to treatment, and association with mortality: An observational study 

      Husabø, Gunnar; Nilsen, Roy Miodini; Flaatten, Hans; Solligård, Erik; Frich, Jan C; Bondevik, Gunnar Tschudi; Braut, Geir Sverre; Walshe, Kieran; Harthug, Stig; Hovlid, Einar (Journal article; Peer reviewed, 2020)
      Background Early recognition of sepsis is critical for timely initiation of treatment. The first objective of this study was to assess the timeliness of diagnostic procedures for recognizing sepsis in emergency departments. ...
    • Effects of external inspections on sepsis detection and treatment: a stepped-wedge study With cluster-level randomisation 

      Husabø, Gunnar; Nilsen, Roy Miodini; Solligård, Erik; Flaatten, Hans; Walshe, Kieran; Frich, Jan C; Bondevik, Gunnar Tschudi; Braut, Geir Sverre; Helgeland, Jon; Harthug, Stig; Hovlid, Einar (Peer reviewed; Journal article, 2020)
      Objective To evaluate the effects of external inspections on (1) hospital emergency departments’ clinical processes for detecting and treating sepsis and (2) length of hospital stay and 30-day mortality. Design Incomplete ...
    • Endotoxin removal in septic shock with the Alteco LPS Adsorber was safe but showed no benefit compared to placebo in the double-blind randomized controlled trial - the Asset Study 

      Lipcsey, Miklos; Tenhunen, Jyrki; Pischke, Soeren; Kuitunen, Anne; Flaatten, Hans; De Geer, Lina; Sjölin, Jan; Frithiof, Robert; Chew, Michelle S.; Bendel, Stepani; Kawati, Rafael; Larsson, Anders; Mollnes, Tom Eirik; Tønnessen, Tor Inge; Rubertsson, Sten (Peer reviewed; Journal article, 2020)
      Purpose: Lipopolysaccharides (LPS) are presumed to contribute to the inflammatory response in sepsis. We investigated if extracorporeal Alteco LPS Adsorber for LPS removal in early gram-negative septic shock was feasible ...
    • Frailty and survival in elderly intensive care patients in Norway 

      Andersen, Finn Husøy; Haaland, Øystein Ariansen; Klepstad, Pål; Flaatten, Hans (Journal article; Peer reviewed, 2021)
      Background Today, 10%-15% of Norwegian intensive care patients are ≥80 years. This proportion will increase significantly over the next 20 years, but it is unlikely that resources for intensive care increase correspondingly. ...
    • Huge variation in obtaining ethical permission for a non-interventional observational study in Europe 

      de Lange, Dylan W.; Guidet, Bertrand R.; Andersen, Finn Husøy; Artigas, Antonio; Bertolini, Guido; Moreno, Rui; Christensen, Steffen; Cecconi, Maurizio; Agvald-Öhman, Christina; Gradišek, Primož; Jung, Christian; Marsh, Brian J.; Oeyen, Sandra; Bollen Pinto, Bernardo; Szczeklik, Wojciech; Watson, Ximena; Zafeiridis, Tilemachos; Flaatten, Hans (Journal article; Peer reviewed, 2019)
      Background Ethical approval (EA) must be obtained before medical research can start. We describe the differences in EA for an pseudonymous, non-interventional, observational European study. Methods Sixteen European ...
    • The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study 

      Jung, Christian; Flaatten, Hans; Fjølner, Jesper; Romano Bruno, Raphael; Wernly, Bernhard; Artigas, Antonio; Pinto, Bernardo Bollen; Schefold, Joerg C.; Wolff, Georg; Kelm, Malte; Beil, Michael; Sviri, Sigal; van Heerden, Peter Vernon; Szczeklik, Wojciech; Czuczwar, Miroslaw; Elhadi, Muhammed; Joannidis, Michael; Oeyen, Sandra; Zafeiridis, Tilemachos; Marsh, Brian; Andersen, Finn Husøy; Moreno, Rui; Cecconi, Maurizio; Leaver, Susannah; Boumendil, Ariane; De Lange, Dylan W.; Guidet, Bertrand (Peer reviewed; Journal article, 2021)
      Background The COVID-19 pandemic has led highly developed healthcare systems to the brink of collapse due to the large numbers of patients being admitted into hospitals. One of the potential prognostic indicators in ...
    • Intensive care for the very old 

      Andersen, Finn Husøy (Doctoral theses at NTNU;2017:166, Doctoral thesis, 2017)
      Introduction: The older population is expected to increase markedly during the next decades. The life expectancy of older patients is increasing, but the prevalence of conditions that require ICU treatment is also growing. ...
    • Long-term survival and quality of life after intensive care for patients 80 years of age or older 

      Andersen, Finn H; Flaatten, Hans; Klepstad, Pål; Romild, Ulla Kristina; Kvåle, Reidar (Journal article; Peer reviewed, 2015)
      Background Comparison of survival and quality of life in a mixed ICU population of patients 80 years of age or older with a matched segment of the general population. Methods We retrospectively analyzed survival of ...
    • Reliability of the Clinical Frailty Scale in very elderly ICU patients: a prospective European study 

      Flaatten, Hans; Guidet, Bertrand; Andersen, Finn Husøy; Artigas, Antonio; Cecconi, Maurizio; Boumendil, Ariane; Elhadi, Muhammed; Fjølner, Jesper; Joannidis, Michael; Jung, Christian; Leaver, Susannah; Marsh, Brian; Moreno, Rui; Oeyen, Sandra; Nalapko, Yuriy; Schefold, Joerg C.; Szczeklik, Wojciech; Walther, Sten; Watson, Ximena; Zafeiridis, Tilemachos; de Lange, Dylan W. (Peer reviewed; Journal article, 2021)
      Purpose Frailty is a valuable predictor for outcome in elderly ICU patients, and has been suggested to be used in various decision-making processes prior to and during an ICU admission. There are many instruments developed ...
    • Sepsis at ICU admission does not decrease 30-day survival in very old patients: a post-hoc analysis of the VIP1 multinational cohort study 

      Ibarz, Mercedes; Boumendil, Ariane; Flaatten, Hans; Andersen, Finn Husøy; Artigas, Antonio (Peer reviewed; Journal article, 2020)
      Background The number of intensive care patients aged ≥ 80 years (Very old Intensive Care Patients; VIPs) is growing. VIPs have high mortality and morbidity and the benefits of ICU admission are frequently questioned. ...
    • Sex-specific outcome disparities in very old patients admitted to intensive care medicine: a propensity matched analysis 

      Wernly, Bernhard; Bruno, Raphael Romano; Kelm, Malte; Boumendil, Ariane; Morandi, Alessandro; Andersen, Finn Husøy; Artigas, Antonio; Finazzi, Stefano; Cecconi, Maurizio; Christensen, Steffen; Faraldi, Loredana; Lichtenauer, Michael; Muessig, Johanna M.; Marsh, Brian; Moreno, Rui; Oeyen, Sandra; Öhman, Christina Agwald; Pinto, Bernadro Bollen; Soliman, Ivo W.; Szczeklik, Wojciech; Niederseer, David; Valentin, Andreas; Watson, Ximena; Leaver, Susannah; Boulanger, Carole; Walther, Sten; Schefold, Jörg C.; Joannidis, Michael; Nalapko, Yuriy; Elhadi, Muhammed; Fjølner, Jesper; Zafeiridis, Tilemachos; De Lange, Dylan W.; Guidet, Bertrand; Flaatten, Hans; Jung, Christian (Peer reviewed; Journal article, 2020)
      Female and male very elderly intensive patients (VIPs) might differ in characteristics and outcomes. We aimed to compare female versus male VIPs in a large, multinational collective of VIPs with regards to outcome and ...