Browsing NTNU Open by Author "Flægstad, Trond"
Now showing items 1-9 of 9
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Composition of gut microbiota of children and adolescents with perinatal HIV infection taking antiretroviral therapy in Zimbabwe
Flygel, Trym Thune; Sovershaeva, Evgeniya; Classen-Weitz, Shantelle; Hjerde, Erik; Mwaikono, Kilaza S.; Odland, Jon Øyvind; Ferrand, Rashida A.; McHugh, Grace; Gutteberg, Tore Jarl; Nicol, Mark P.; Cavanagh, Jorunn Pauline; Flægstad, Trond (Journal article; Peer reviewed, 2019)Background Human immunodeficiency virus (HIV) infection causes impairment of the gastrointestinal barrier, with substantial depletion of CD4+ T cells in the gut. Antiretroviral therapy (ART) restores CD4+ counts and may ... -
Exhaled nitric oxide is associated with inflammatory biomarkers and risk of acute respiratory exacerbations in children with HIV-associated chronic lung disease
Flygel, Trym Thune; Hameiri-Bowen, Dan; Simms, Victoria; Rowland-Jones, Sarah; Ferrand, Rashida Abbas; Bandason, Tsitsi; Yindom, Louis-Marie; Odland, Jon Øyvind; Cavanagh, Jorunn Pauline; Flægstad, Trond; Sovershaeva, Evgeniya (Peer reviewed; Journal article, 2023)Objectives Chronic lung disease is a recognized complication in children with HIV. Acute respiratory exacerbations (ARE) are common among this group and cause significant morbidity. Exhaled nitric oxide (eNO) is a known ... -
Health in overweight children: 2-year follow-up of Finnmark Activity School-a randomised trial
Kokkvoll, Ane Sofie; Grimsgaard, Sameline; Steinsbekk, Silje; Flægstad, Trond; Njølstad, Inger (Journal article; Peer reviewed, 2014) -
History of tuberculosis is associated with lower exhaled nitric oxide levels in HIV-infected children
Sovershaeva, Evgeniya; Kranzer, Katharina; McHugh, Grace; Bandason, Tsitsi; Majonga, Edith D.; Usmani, Omar S.; Rowland-Jones, Sarah; Gutteberg, Tore Jarl; Flægstad, Trond; Ferrand, Rashida A.; Odland, Jon Øyvind (Journal article; Peer reviewed, 2019)Objective: HIV disrupts host defense mechanisms and maintains chronic inflammation in the lung. Nitric oxide is a marker of lung inflammation and can be measured in the exhaled air. We investigated the relationship between ... -
The Norwegian childhood cancer biobank
Hermansen, Johanne Uthus; Wojcik, Dorota; Robinson, Nina; Pahnke, Jens; Haugland, Hans Kristian; Jamtøy, Ann-Helen; Flægstad, Trond; Halvorsen, Hanne; Lund, Bendik; Baumbusch, Lars Oliver; Munthe-Kaas, Monica Cheng (Peer reviewed; Journal article, 2021)Background The rapidly expanding era of “omics” research is highly dependent on the availability of quality-proven biological material, especially for rare conditions such as pediatric malignancies. Professional biobanks ... -
Patterns of detectable viraemia among children and adults with HIV infection taking antiretroviral therapy in Zimbabwe
Sovershaeva, Evgeniya; Shamu, Tinei; Wilsgaard, Tom; Bandason, Tsitsi; Flægstad, Trond; Katzenstein, David; Ferrand, Rashida A.; Odland, Jon Øyvind (Journal article; Peer reviewed, 2018)Objective To investigate the incidence and predictors of viraemia among individuals on antiretroviral therapy (ART) in Harare, Zimbabwe. Methods Children (0–19 years) and adults (>19 years) starting ART between 2013 ... -
Single versus multiple-family intervention in childhood overweight - Finnmark Activity School: A randomised trial
Kokkvoll, Ane Sofie; Grimsgaard, Sameline; Ødegård, Rønnaug; Flægstad, Trond; Njølstad, Inger (Journal article; Peer reviewed, 2014)Objective: To compare a new comprehensive lifestyle programme performed in groups of families with overweight (included obese) children with a more conventional single-family programme. The study design and interim ... -
The synthetic antimicrobial peptide LTX21 induces inflammatory responses in a human whole blood model and a murine peritoneum model
Granslo, Hildegunn Norbakken; Aarag, Elizabeth; Esaiassen, Eirin; Christophersen, Lars; Jensen, Peter Østrup; Mollnes, Tom Eirik; Moser, Claus; Flægstad, Trond; Klingenberg, Claus; Cavanagh, Jorunn Pauline (Peer reviewed; Journal article, 2019)The global spread of antimicrobial resistance and the increasing number of immune‐compromised patients are major challenges in modern medicine. Targeting bacterial virulence or the human host immune system to increase host ... -
The synthetic antimicrobial peptide LTX21 induces inflammatory responses in a human whole blood model and a murine peritoneum model
Granslo, Hildegunn Norbakken; Aarag, Elizabeth; Esaiassen, Eirin; Christophersen, Lars; Jensen, Peter Østrup; Mollnes, Tom Eirik; Moser, Claus; Flægstad, Trond; Klingenberg, Claus; Cavanagh, Jorunn Pauline (Peer reviewed; Journal article, 2019)The global spread of antimicrobial resistance and the increasing number of immune‐compromised patients are major challenges in modern medicine. Targeting bacterial virulence or the human host immune system to increase host ...