• A novel compound isolated from Sclerochloa dura has anti-inflammatory effects 

      Bukhari, Syed Majid; Feuerherm, Astrid Jullumstrø; Tunset, Hanna Maja; Isaksen, Stian Moe; Sæther, Mari; Thvedt, Thor Håkon Krane; Villa Gonzalez, Susana; Schmid, Rudolf; Brunsvik, Anders; Fuglseth, Erik; Zlatković, Bojan; Johansen, Berit; Simic, Nebojsa (Journal article; Peer reviewed, 2016)
      The activation of phospholipase A2 (PLA2) by means of pro-inflammatory cytokines results in the subsequent release of arachidonic acid (AA) and generates eicosanoids, which further propagate inflammation. Through cyclooxygenases ...
    • Anti-inflammatory and antioxidant activities of Sclerochloa dura (Poaceae) 

      Bukhari, Syed Majid; Feuerherm, Astrid Jullumstrø; Boulfrad, Fayssal; Zlatkovic, Bojan; Johansen, Berit; Simic, Nebojsa (Journal article; Peer reviewed, 2014)
      The plant Sclerochloa dura is traditionally used in South-East Serbia to treat menstrual disorders characterized by pain and excessive bleeding. According to subjects’ statements, a reduction in bleeding and pain is ...
    • Anti-vascular effects of the cytosolic phospholipase A2 inhibitor AVX235 in a patient-derived basal-like breast cancer model 

      Kim, Eugene; Tunset, Hanna Maja; Cebulla, Jana; Vettukattil, Muhammad Riyas; Helgesen, Heidi; Feuerherm, Astrid Jullumstrø; Engebråten, Olav; Mælandsmo, Gunhild; Johansen, Berit; Moestue, Siver Andreas (Journal article; Peer reviewed, 2016)
      Background: Group IVA cytosolic phospholipase A2 (cPLA2α) plays an important role in tumorigenesis and angiogenesis. It is overexpressed in basal-like breast cancer (BLBC), which is aggressive and usually triple-negative, ...
    • Cellular Effects of Insulin in Human THP-1 Monocytes 

      Naderi, Jamal (Master thesis, 2015)
      Excess of insulin in the circulating blood relative to the level of glucose (Hyperinsulinemia) may be linked to systemic low-grade inflammation and some chronic disease such as the metabolic syndrome, type 2 diabetes ...
    • Characterization of Vitamin k2 FUNTIONS IN Saos-2 osteoblasts 

      Strand, Siv Kristine Sola (Master thesis, 2012)
      MK-7 as a potential treatment against osteoporosis, favoring bone formation, was explored in this thesis. Today most treatments for bone loss target suppression of osteoclastogenesis. Biological activity and cytotoxicity ...
    • Cytosolic group IVA phospholipase A2 inhibitors, AVX001 and AVX002, ameliorate collagen induced arthritis 

      Feuerherm, Astrid Jullumstrø; Dennis, Edward A.; Johansen, Berit (Journal article; Peer reviewed, 2019)
      Background: Cytosolic phospholipase A2 group IVA (cPLA2α)-deficient mice are resistant to collagen-induced arthritis, suggesting that cPLA2α is an important therapeutic target. Here, the anti-inflammatory effects of the ...
    • Cytosolic Phospholipase A2 Alpha Regulates TLR Signaling and Migration in Metastatic 4T1 Cells 

      Tunset, Hanna Maja; Feuerherm, Astrid Jullumstrø; Selvik, Linn-Karina M.; Johansen, Berit; Moestue, Siver Andreas (Journal article; Peer reviewed, 2019)
      Metastatic disease is the leading cause of death in breast cancer patients. Disrupting the cancer cell’s ability to migrate may be a strategy for hindering metastasis. Cytosolic phospholipase A2 α (cPLA2α), along with ...
    • Cytosolic phospholipase A2 modulates TLR2 signaling in synoviocytes 

      Sommerfelt, Randi Magnus; Feuerherm, Astrid Jullumstrø; Skuland, Trine; Johansen, Berit (Journal article; Peer reviewed, 2015)
      Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic synovitis leading to destruction of cartilage and bone. PLA2 enzymes are key players in inflammation regulating the release of unsaturated fatty ...
    • Cytosolic phospholipase A2 regulates TNF-induced production of joint destructive effectors in synoviocytes 

      Sommerfelt, Randi Magnus; Feuerherm, Astrid Jullumstrø; Jones, Kymry; Johansen, Berit (Journal article; Peer reviewed, 2013)
      Introduction: Rheumatoid arthritis (RA) is an inflammatory disease of the joint characterized by chronic synovitis causing pain, swelling and loss of function due to destruction of cartilage and bone. The complex series ...
    • Oral health in children and adolescents with juvenile idiopathic arthritis - a systematic review and meta-analysis 

      Skeie, Marit Slåttelid; Gil, Elisabeth; Cetrelli, Lena; Rosén, Annika; Fischer, Johannes Maria; Åstrøm, Anne Nordrehaug; Luukko, Keijo; Feuerherm, Astrid Jullumstrø; Sen, Abhijit; Frid, Paula; Rygg, Marite; Bletsa, Athanasia (Journal article; Peer reviewed, 2019)
      Background Observational studies examining the association between oral health and juvenile idiopathic arthritis (JIA) among children and adolescents have reported inconsistent findings. The aims of this systematic review ...