• ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA 

      Van den Born, Erwin; Vågbø, Cathrine Broberg; Songe-Møller, Lene; Leihne, VIbeke; Lien, Guro Flor; Leszczynska, G; Malkiewicz, A; Krokan, Hans Einar; Kirpekar, F; Klungland, Arne; Falnes, Pål (Journal article; Peer reviewed, 2011)
      Mammals have nine different homologues (ALKBH1–9) of the Escherichia coli DNA repair demethylase AlkB. ALKBH2 is a genuine DNA repair enzyme, but the in vivo function of the other ALKBH proteins has remained elusive. It ...
    • Human ALKBH4 Interacts with Proteins Associated with Transcription 

      Bjørnstad, Linn; Meza, Trine Johansen; Otterlei, Marit; Olafsrud, Solveig Mjelstad; Meza-Zepeda, Leonardo Andrés; Falnes, Pål (Journal article; Peer reviewed, 2012)
      The Fe(II)- and 2-oxoglutarate (2OG)-dependent dioxygenase AlkB from E. coli is a demethylase which repairs alkyl lesions in DNA, as well as RNA, through a direct reversal mechanism. Humans possess nine AlkB homologs ...
    • Protozoan ALKBH8 Oxygenases Display both DNA Repair and tRNA Modification Activities 

      Zdzalik, Daria; Vågbø, Cathrine Broberg; Kirpekar, F; Davydova, Erna; Puścian, Alicja; Maciejewska, Agnieszka M.; Krokan, Hans Einar; Klungland, Arne; Tudek, Barbara; Van den Born, Erwin; Falnes, Pål (Journal article; Peer reviewed, 2014)
      The ALKBH family of Fe(II) and 2-oxoglutarate dependent oxygenases comprises enzymes that display sequence homology to AlkB from E. coli, a DNA repair enzyme that uses an oxidative mechanism to dealkylate methyl and etheno ...
    • Roles of Trm9-and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA 

      Leihne, VIbeke; Kirpekar, F; Vågbø, Cathrine Broberg; Van den Born, Erwin; Krokan, Hans Einar; Grini, Paul Eivind; Meza, Trine Johansen; Falnes, Pål (Journal article; Peer reviewed, 2011)
      Uridine at the wobble position of tRNA is usually modified, and modification is required for accurate and efficient protein translation. In eukaryotes, wobble uridines are modified into 5-methoxycarbonylmethyluridine (mcm ...
    • The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage 

      Meza, Trine Johansen; Moen, Marivi; Vågbø, Cathrine Broberg; Krokan, Hans Einar; Klungland, Arne; Grini, Paul Eivind; Falnes, Pål (Journal article; Peer reviewed, 2012)
      The Escherichia coli AlkB protein (EcAlkB) is a DNA repair enzyme which reverses methylation damage such as 1-methyladenine (1-meA) and 3-methylcytosine (3-meC). The mammalian AlkB homologues ALKBH2 and ALKBH3 display ...