Blar i NTNU Open på forfatter "El-Behairy, Mohammed Farrag"
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Enantioselective chromatographic separation and lipase catalyzed asymmetric resolution of biologically important chiral amines
El-Behairy, Mohammed Farrag; Hassan, Rasha M.; Sundby, Eirik (Peer reviewed; Journal article, 2021)Cyanoacetamides are vital synthons in synthetic organic chemistry. However, methods to enantiopure cyanoacetamides have not yet been well explored. In this work, the preparation of cyanoacetamide synthons RS-(1a–4a) or ... -
Lipase Catalysed Kinetic Resolution of Stiripentol
Jacobsen, Elisabeth Egholm; Anthonsen, Thorleif; El-Behairy, Mohammed Farrag; Sundby, Eirik; Aboul-Enein, Mohamed Nabil; Attia, Mohamed Ibrahim; El-Azzouny, Aida Abd El-Sattar; Amin, Kamilia M.; Abdel-Rehim, Mohamed (Journal article; Peer reviewed, 2012)Kinetic resolution of rac-Stiripentol, catalysed by lipase A from Candida antarctica by esterification with vinyl butanoate was performed with an E-value of 24. This allowed isolation of (3S)-Stiripentol with an ee of 86 ... -
One-step lipase-catalysed preparation of eslicarbazepine
El-Behairy, Mohammed Farrag; Sundby, Eirik (Peer reviewed; Journal article, 2016)The antiepileptic eslicarbazepine (S-licarbazepine) has been prepared in one step from its racemic form RS-licarbazepine via lipase catalysed kinetic resolution. A novel stereoselective simultaneous HPLC separations of ...