Browsing NTNU Open by Author "Dueland, Svein"
Now showing items 1-17 of 17
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Circulating Exosomal miR-141-3p and miR-375 in Metastatic Progression of Rectal Cancer
Meltzer, Sebastian; Bjørnetrø, Tonje; Lyckander, Lars Gustav; Flatmark, Kjersti; Dueland, Svein; Samiappan, Rampradeep; Johansen, Christin; Kalanxhi, Ert; Ree, Anne Hansen; Redalen, Kathrine (Journal article; Peer reviewed, 2019)As many as 30% to 40% of locally advanced rectal cancer (LARC) patients experience metastatic progression of the disease. Recognizing the potential of the genetic cargo in tumor-derived exosomes, we hypothesized that plasma ... -
The circulating soluble form of the CD40 costimulatory immune checkpoint receptor and liver metastasis risk in rectal cancer
Meltzer, Sebastian; Kristensen, Annette Torgunrud; Abrahamsson, Hanna Josefine; Solbakken, Arne Mide; Flatmark, Kjersti; Dueland, Svein; Bakke, Kine Mari; Bousquet, Paula; Negård, Anne; Johansen, Christin; Lyckander, Lars Gustav; Larsen, Finn Ole; Schou, Jakob Vasehus; Redalen, Kathrine; Ree, Anne Hansen (Peer reviewed; Journal article, 2021)Background In colorectal cancer, the inflamed tumour microenvironment with its angiogenic activities is immune- tolerant and incites progression to liver metastasis. We hypothesised that angiogenic and inflammatory factors ... -
Corrigendum to “Circulating exosomal miR-141-3p and miR-375 in metastatic progression of rectal cancer” [Transl Oncol 12 (8) (2019) 1038-1044]
Meltzer, Sebastian; Bjørnetrø, Tonje; Lyckander, Lars Gustav; Flatmark, Kjersti; Dueland, Svein; Samiappan, Rampradeep; Johansen, Christin; Kalanxhi, Erta; Ree, Anne Hansen; Redalen, Kathrine (Peer reviewed; Journal article, 2020) -
Diffusion-weighted magnetic resonance imaging of rectal cancer: tumour volume and perfusion fraction predict chemoradiotherapy response and survival
Bakke, Kine Mari; Hole, Knut Håkon; Dueland, Svein; Kotanska-Grøholt, Krystyna; Flatmark, Kjersti; Ree, Anne Hansen; Seierstad, Therese; Redalen, Kathrine Røe (Journal article, 2017)Background: In locally advanced rectal cancer (LARC), responses to preoperative treatment are highly heterogeneous and more accurate diagnostics are likely to enable more individualised treatment approaches with improved ... -
High level of circulating vitamin D during neoadjuvant therapy may lower risk of metastatic progression in high-risk rectal cancer
Abrahamsson, Hanna Josefine; Porojnicu, Alina Carmen; Lindstrøm, Jonas Christoffer; Dueland, Svein; Flatmark, Kjersti; Hole, Knut Håkon; Seierstad, Therese; Moan, Johan Emilian; Redalen, Kathrine; Meltzer, Sebastian; Ree, Anne Hansen (Journal article; Peer reviewed, 2019)Background:Following curative-intent neoadjuvant therapy in locally advanced rectal cancer, metastaticprogression is still dominant. We investigated if patients’circulating 25-hydroxyvitamin D [25(OH)D] levels wereassociated ... -
High level of circulating vitamin D during neoadjuvant therapy may lower risk of metastatic progression in high-risk rectal cancer
Abrahamsson, Hanna Josefine; Porojnicu, Alina Carmen; Lindstrøm, Jonas Christoffer; Dueland, Svein; Flatmark, Kjersti; Hole, Knut Håkon; Seierstad, Therese; Moan, Johan Emilian; Redalen, Kathrine Røe; Meltzer, Sebastian; Ree, Anne Hansen (Journal article; Peer reviewed, 2019)Background: Following curative-intent neoadjuvant therapy in locally advanced rectal cancer, metastatic progression is still dominant. We investigated if patients’ circulating 25-hydroxyvitamin D [25(OH)D] levels were ... -
Immunogenic cell death by neoadjuvant oxaliplatin and radiation protects against metastatic failure in high-risk rectal cancer.
Bains, Simer Jit; Abrahamsson, Hanna Josefine; Flatmark, Kjersti; Dueland, Svein; Hole, Knut Håkon; Seierstad, Therese; Redalen, Kathrine; Meltzer, Sebastian; Ree, Anne Hansen (Journal article; Peer reviewed, 2019)Objective High rates of systemic failure in locally advanced rectal cancer call for a rational use of conventional therapies to foster tumor-defeating immunity. Methods We analyzed the high-mobility group box-1 ... -
Impact of KRAS, BRAF and microsatellite instability status after cytoreductive surgery and HIPEC in a national cohort of colorectal peritoneal metastasis patients
Larsen, Stein Gunnar; Goscinski, Mariusz Adam; Dueland, Svein; Steigen, Sonja Eriksson; Hofsli, Eva; Torgunrud, A.; Lund-Iversen, Marius; Dagenborg, Vegar Johansen; Flatmark, Kjersti; Sorbye, Halfdan (Peer reviewed; Journal article, 2021)Patients with metastatic colorectal cancer (mCRC) carrying BRAF (mutBRAF) or KRAS mutation (mutKRAS) have an inferior prognosis after liver or lung surgery, whereas the prognostic role in the context of peritoneal metastasis ... -
Increased Local Inflammatory Response to MOC31PE Immunotoxin After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
Thorgersen, Ebbe Billmann; Asvall, Jørund; Frøysnes, Ida Storhaug; Schjalm, Camilla; Larsen, Stein Gunnar; Dueland, Svein; Andersson, Yvonne; Fodstad, Øystein; Mollnes, Tom Eirik; Flatmark, Kjersti (Journal article; Peer reviewed, 2021)Background - Despite extensive cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC), most patients with resectable peritoneal metastases from colorectal cancer experience disease relapse. MOC31PE ... -
Markers of mitochondrial metabolism in tumor hypoxia, systemic inflammation, and adverse outcome of rectal cancer
Bousquet, Paula; Meltzer, Sebastian; Sønstevold, Linda; Esbensen, Qin Ying; Dueland, Svein; Flatmark, Kjersti; Sitter, Beathe; Bathen, Tone Frost; Seierstad, Therese; Redalen, Kathrine; Eide, Lars; Ree, Anne Hansen (Journal article; Peer reviewed, 2019)Tumor hypoxia contributes to therapy resistance and metastatic progression of locally advanced rectal cancer (LARC). We postulated that the tumor mitochondrial metabolism, manifested by reactive oxygen species (ROS) and ... -
MRI-based automatic segmentation of rectal cancer using 2D U-Net on two independent cohorts
Knuth, Franziska Hanna; Adde, Ingvild Askim; Huynh, Bao Ngoc; Grøndahl, Aurora Rosvoll; Winter, René; Negård, Anne; Holmedal, Stein Harald; Meltzer, Sebastian; Ree, Anne Hansen; Flatmark, Kjersti; Dueland, Svein; Hole, Knut Håkon; Seierstad, Therese; Redalen, Kathrine; Futsæther, Cecilia Marie (Peer reviewed; Journal article, 2021)Background Tumor delineation is time- and labor-intensive and prone to inter- and intraobserver variations. Magnetic resonance imaging (MRI) provides good soft tissue contrast, and functional MRI captures tissue properties ... -
MRI-based automatic segmentation of rectal cancer using 2D U-Net on two independent cohorts
Knuth, Franziska Hanna; Adde, Ingvild Askim; Huynh, Bao Ngoc; Groendahl, Aurora Rosvoll; Winter, René Mario; Negård, Anne; Holmedal, Stein Harald; Meltzer, Sebastian; Ree, Anne Hansen; Flatmark, Kjersti; Dueland, Svein; Hole, Knut Håkon; Seierstad, Therese; Redalen, Kathrine Røe; Futsaether, Cecilie Maria (Peer reviewed; Journal article, 2022)Background: Tumor delineation is time- and labor-intensive and prone to inter- and intraobserver variations. Magnetic resonance imaging (MRI) provides good soft tissue contrast, and functional MRI captures tissue properties ... -
Neoadjuvant chemotherapy versus surgery first for resectable pancreatic cancer (Norwegian Pancreatic Cancer Trial - 1 (NorPACT-1)) – study protocol for a national multicentre randomized controlled trial
Labori, Knut Jørgen; Lassen, Kristoffer; Hoem, Dag; Grønbech, Jon Erik; Søreide, Jon Arne; Mortensen, Kim Erlend; Smaaland, Rune; Sorbye, Halfdan; Verbeke, Caroline Sophie; Dueland, Svein (Journal article; Peer reviewed, 2017)Background: Pancreatic cancer is the fourth leading cause of cancer-related death. While surgical resection remains the foundation for potentially curative treatment, survival benefit is achieved with adjuvant oncological ... -
Re-irradiation for recurrent rectal cancer – a single-center experience
Al-Haidari, Ghazwan Ahmed Dhia Eldin; Skovlund, Eva; Undseth, Christine; Rekstad, Bernt Louni; Larsen, Steinar; Åsli, Linn Merete; Dueland, Svein; Malinen, Eirik; Guren, Marianne (Peer reviewed; Journal article, 2020)Background: There is no clear consensus on the use of re-irradiation (reRT) in the management of locally recurrent rectal cancer (LRRC). The aim of the present study was to investigate all reRT administered for rectal ... -
Sex-related differences in primary metastatic site in rectal cancer; associated with hemodynamic factors?
Meltzer, Sebastian; Bakke, Kine Mari; Rød, Karina Lund; Negård, Anne; Flatmark, Kjersti; Solbakken, Arne Mide; Kristensen, Annette Torgunrud; Fuglestad, Anniken Jørlo; Kersten, Christian; Dueland, Svein; Seierstad, Therese; Hole, Knut Håkon; Lyckander, Lars Gustav; Larsen, Finn Ole; Schou, Jakob Vasehus; Brown, Dawn; Abrahamsson, Hanna Josefine; Redalen, Kathrine; Ree, Anne Hansen (Journal article; Peer reviewed, 2019)Background and purpose We investigated how features relating to pelvic cavity anatomy and tumor hemodynamic factors may influence systemic failure in rectal cancer. Materials and methods Rectal cancer patients (207 ... -
The Spillover Effects of Extending Liver Transplantation to Patients with Colorectal Liver Metastases: A Discrete Event Simulation Analysis
Sjule, Hanna Meidell; Vinter, Caroline Andrea; Dueland, Svein; Line, Pål Dag; Burger, Emily Annika; Bjørnelv, Gudrun Maria Waaler (Journal article; Peer reviewed, 2024)Background: Liver transplantation is an alternative treatment for patients with nonresectable colorectal cancer liver-only metastases (CRLM); however, the potential effects on wait-list time and life expectancy to other ... -
Systemic immune response induced by oxaliplatin-based neoadjuvant therapy favours survival without metastatic progression in high-risk rectal cancer
Kalanxhi, Ert; Meltzer, Sebastian; Schou, Jakob Vasehus; Larsen, Finn Ole; Dueland, Svein; Flatmark, Kjersti; Jensen, Benny Vittrup; Hole, Knut Håkon; Seierstad, Therese; Redalen, Kathrine; Nielsen, Dorte Lisbet; Ree, Anne Hansen (Journal article; Peer reviewed, 2018)Background Systemic failure remains a challenge in rectal cancer. We investigated the possible systemic anti-tumour immune activity invoked within oxaliplatin-based neoadjuvant therapy. Methods In two high-risk patient ...