Browsing NTNU Open by Author "Drozdov, Ignat"
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Gene Network Inference and Biochemical Assessment Delineates GPCR Pathways and CREB Targets in Small Intestinal Neuroendocrine Neoplasia
Drozdov, Ignat; Svejda, Bernhard; Gustafsson, Björn; Mane, S; Pfragner, Roswitha; Kidd, Mark; Modlin, Irvin M (Journal article; Peer reviewed, 2011)Small intestinal (SI) neuroendocrine tumors (NET) are increasing in incidence, however little is known about their biology. High throughput techniques such as inference of gene regulatory networks from microarray experiments ... -
Relevance of TNBS-Colitis in Rats: A Methodological Study with Endoscopic, Historical and Transcripttomic Characterization and Correlation to IBD
Brenna, Øystein; Furnes, Marianne Waldum; Drozdov, Ignat; Granlund, Atle Van Beelen; Flatberg, Arnar; Sandvik, Arne Kristian; Zwiggelaar, Rosalie; Mårvik, Ronald; Nordrum, Ivar Skjåk; Kidd, Mark; Gustafsson, Björn (Journal article; Peer reviewed, 2013)Background: Rectal instillation of trinitrobenzene sulphonic acid (TNBS) in ethanol is an established model for inflammatory bowel disease (IBD). We aimed to 1) set up a TNBS-colitis protocol resulting in an endoscopic ... -
The guanylate cyclase-C signaling pathway is down-regulated in inflammatory bowel disease
Brenna, Øystein; Bruland, Torunn; Furnes, Marianne Waldum; Granlund, Atle Van Beelen; Drozdov, Ignat; Emgård, Johanna; Brønstad, Gunnar; Kidd, Mark; Sandvik, Arne Kristian; Gustafsson, Björn (Journal article; Peer reviewed, 2015)Objective. Activation of membrane receptor guanylate cyclase-C (GC-C) is implicated in gastrointestinal fluid and electrolyte balance, preservation of intestinal barrier integrity, anti-trophic effects and inhibition of ... -
Whole Genome Gene Expression Meta-Analysis of Inflammatory Bowel Disease Colon Mucosa Demonstrates Lack of Major Differences between Crohn's Disease and Ulcerative Colitis
Granlund, Atle Van Beelen; Flatberg, Arnar; Østvik, Ann Elisabet; Drozdov, Ignat; Gustafsson, Björn; Kidd, Mark; Beisvag, Vidar; Torp, Sverre Helge; Waldum, Helge; Martinsen, Tom Christian; Damås, Jan Kristian; Espevik, Terje; Sandvik, Arne Kristian (Journal article; Peer reviewed, 2013)Background: In inflammatory bowel disease (IBD), genetic susceptibility together with environmental factors disturbs gut homeostasis producing chronic inflammation. The two main IBD subtypes are Ulcerative colitis (UC) ...