Blar i NTNU Open på forfatter "Draget, Kurt Ingar"
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Alginate gels with a combination of calcium and chitosan oligomer mixtures as crosslinkers
Feng, Yiming; Kopplin, Georg; Sato, Kimihiko; Draget, Kurt Ingar; Vårum, Kjell Morten (Journal article, 2017)Alginates are polysaccharides that are widely used in relation to their ability to form gels. Recently we reported that alginates may also form gels with chitosan oligomers as crosslinkers (Khong, Aarstad, Skjåk-Bræk, ... -
Bioactively filled gelatin gels; challenges and opportunities
Dille, Morten Johnsen; Hattrem, Magnus Nergård; Draget, Kurt Ingar (Journal article; Peer reviewed, 2016)Soft, chewable gelatin matrices represent an excellent alternative to traditional oral administration forms (tablets, soft and hard capsules) for pharma- and nutraceuticals; especially for the pediatric and geriatric ... -
Biosimilar Mucus as a Model System for Small Intestinal Mucus: -Evaluating the Applicability for Nanoparticle Drug Delivery Studies
Våset, Frida Sandvik (Master thesis, 2014)Slimhinnene i mage/tarm, luftveier og urogenitaliene er store mål for legemiddellevering i kroppen. Mucus blir uskilt fra slimhinnene og kan skape en barriere når legemidler i form av biologiske makromolekyler skal ... -
Calcium binding and calcium-induced gelation of normal low-methoxyl pectin modified by low molecular-weight polyuronate fraction
Nakauma, Makoto; Funami, Takahiro; Fang, Yapeng; Nishinari, Katsuyoshi; Draget, Kurt Ingar; Phillips, Glyn O. (Journal article, 2017)Functions of low molecular-weight polyuronate fractions in the calcium binding and calcium-induced gelation of normal low-methoxyl pectin (LMP) were investigated. The fractions from pectin with two different degrees of ... -
Characterisation of a novel gelatin-based system for oral delivery of pharmaceuticals and nutraceuticals
Dysvik, Anna (Master thesis, 2015)Abstract Oral delivery is one of the most utilized routes for pharmaceutical delivery, due to its simplicity, convenience and thoroughly evaluated safety-profile. Significant drawbacks are however associated with ... -
Characterization and Properties of Hydrogels Made from Neutral Soluble Chitosans
Franzen, Henry M; Draget, Kurt Ingar; Langebäck, Joakim; Nilsen-Nygaard, Julie (Journal article; Peer reviewed, 2015)The current paper focuses on the preparation and some characteristics of viscoelastic hydrogels, ViscoGels™, made from chitosans having a random acylation pattern. Three different chitosan batches with a high fraction of ... -
Chitosan: Gels and interfacial properties
Nilsen-Nygaard, Julie; Strand, Sabina P.; Vårum, Kjell Morten; Draget, Kurt Ingar; Nordgård, Catherine Taylor (Journal article; Peer reviewed, 2015)Chitosan is a unique biopolymer in the respect that it is abundant, cationic, low-toxic, non-immunogenic and biodegradable. The relative occurrence of the two monomeric building units (N-acetyl-glucosamine and d-glucosamine) ... -
Co association of mucus modulating agents and nanoparticles for mucosal drug delivery
Nordgård, Catherine Taylor; Draget, Kurt Ingar (Journal article; Peer reviewed, 2018)Nanoparticulate drug delivery systems (nDDS) offer a variety of options when it comes to routes of administration. One possible path is crossing mucosal barriers, such as in the airways and in the GI tract, for systemic ... -
Confocal reflectance microscopy and multiple particle tracking for the study of the gelation of biopolymers
Haug, Bente; Nordgård, Catherine Taylor; Draget, Kurt Ingar; Bjørkøy, Astrid (Journal article; Peer reviewed, 2018)The combination of confocal reflectance imaging (CRM) and simultaneous multiple particle tracking (MPT) with mean-square displacement (MSD) analysis is a new method for studying the gelation of biopolymers. In addition to ... -
Direct Determination of Chitosan–Mucin Interactions Using a Single-Molecule Strategy: Comparison to Alginate–Mucin Interactions
Haugstad, Kristin Elisabeth; Håti, Armend Gazmeno; Nordgård, Catherine Taylor; Adl, Patricia S.; Maurstad, Gjertrud; Sletmoen, Marit; Draget, Kurt Ingar; Dias, Rita de Sousa; Stokke, Bjørn Torger (Journal article; Peer reviewed, 2015)Aqueous chitosan possesses attractive interaction capacities with various molecular groups that can be involved in hydrogen bonds and electrostatic and hydrophobic interactions. In the present paper, we report on the direct ... -
Drug Delivery Using Oral Vehicles: Controlled Release in the GI-tract
Sæther, Maren (Master thesis, 2012)Oral delivery is considered a convenient route for administration of pharmaceuticals. Great effort has been made to optimize oral delivery vehicles to increase the bioavailability of the pharmaceutical, and enhance patient ... -
Enzyminhibering av guluronatoligomere i farmasøytiske applikasjoner
Røyrvik, Brita (Master thesis, 2011)Alginat har en lang tradisjon som en allsidig marin ressurs. Det har i en årrekke blitt forsket på mulige anvendelser av alginat. Alginatets gelingsevne er den egenskapen som for det meste er blitt utnyttet. I de senere ... -
Extracellular matrix modifications by oligoguluronates for cancer treatment
Haug, Bente (Master thesis, 2018)Type I collagen is the main structural protein of the extracellular matrix, and is abnormally produced in many types of solid tumours. The presence of a thick and linearised collagen fibres constituting a dense network in ... -
Ibuprofen-in-cyclodextrin-in-W/O/W emulsion - Improving the initial and long-term encapsulation efficiency of a model active ingredient.
Hattrem, Magnus; Kristiansen, Kåre Andre; Aachmann, Finn Lillelund; Dille, Morten Johnsen; Draget, Kurt Ingar (Journal article; Peer reviewed, 2015)A challenge in formulating water-in-oil-in-water (W/O/W) emulsions is the uncontrolled release of the encapsulated compound prior to application. Pharmaceuticals and nutraceuticals usually have amphipathic nature, which ... -
Is dehulling of peas and faba beans necessary prior to dry fractionation for the production of protein- and starch-rich fractions? Impact on physical properties, chemical composition and techno-functional properties
do Carmo, Cátia Saldanha; Silventoinen, Pia; Nordgård, Catherine Taylor; Poudroux, Claire; Dessev, Tzevetelin; Zobel, Hanne; Holtekjølen, Ann Katrin; Draget, Kurt Ingar; Holopainen-Mantila, Ulla; Knutsen, Svein Halvor; Sahlstrøm, Stefan (Journal article; Peer reviewed, 2020)Dehulling of peas and faba beans prior to milling and air classification was evaluated, namely its impact on physical properties, chemical composition and techno-functional properties of the fractions. Dry fractionation ... -
Levering av vannløselige molekyler gjennom hud: Diffusjon av molekyler gjennom stratum corneum
Eiken, Karianne Birkestøl (Master thesis, 2011)En transdermal leveringsform gir store fordeler framfor oral, intramuskulær og intravenøs levering, men byr også på noen utfordringer. Den største utfordringen er at kun et begrenset antall molekyler kan administreres på ... -
Mechanical properties of 67NR tumours are broadly independent of the immune status of the host mouse
Nordgård, Catherine Taylor; Rao, Shalini Vasudev; Dille, Morten Johnsen; Steigedal, Tonje S.; Draget, Kurt Ingar (Journal article; Peer reviewed, 2017)Tumour stiffness is increasingly seen as a clinically relevant parameter, with increased stiffness being linked to poorer prognosis, but it is also one that is not inherently easy to measure either in vivo or ex vivo. We ... -
Mechanism of Action of G-blocks: Is calcium involved?
Røe, Marit Vaagen (Master thesis, 2013)The mucus barrier coats the internal surfaces in the body and is one of nature?s success stories. Due to the physiological importance of it there has been extensive research on mucus and mucins for decades. Several mechanisms ... -
Mucus barrier components, challenges for nanoscale drug delivery
Jalalian Javadpour, Hamid (Master thesis, 2013)In this present study changes in nanoparticles motion were explored in the presence and the absence of G-blocks in mucus matrices such as; porcine gastric mucus (45 mg/ml), and a mixture of porcine gastric mucus + polymeric ... -
Nanoparticle Mobility in Pig Small Intestine Mucus (PSIM) - Optimization of Methods used to study Diffusion of Nanoparticles through PSIM, and the Effect of G-block
Wien, Ingrid (Master thesis, 2015)In this thesis, methods for studying diffusion of nanoparticles through pig small intestine mucus (PSIM) were to be studied and optimized. The nanoparticles used were different types of FluoSpheres® and also rhodamine ...