Blar i NTNU Open på forfatter "Draget, Kurt Ingar"
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Alginate Blocks and Block Polysaccharides: A Review
Solberg, Amalie; Draget, Kurt Ingar; Schatz, Christophe; Christensen, Bjørn E. (Peer reviewed; Journal article, 2023)Alginates consist of distinct blocks with different physical properties. This short review focuses on research carried out in Trondheim related to the early discovery of the block structure, their isolation, their different ... -
Alginate gels crosslinked with chitosan oligomers - a systematic investigation into alginate block structure and chitosan oligomer interaction
Kopplin, Georg; Lervik, Anders; Draget, Kurt Ingar; Aachmann, Finn Lillelund (Peer reviewed; Journal article, 2021)Three alginates with fundamentally different block structures, poly-M, poly-G, and poly-MG, have been investigated upon ionic crosslinking with chitosan oligosaccharides (CHOS), using circular dichroism (CD), rheology, and ... -
Alginate gels with a combination of calcium and chitosan oligomer mixtures as crosslinkers
Feng, Yiming; Kopplin, Georg; Sato, Kimihiko; Draget, Kurt Ingar; Vårum, Kjell Morten (Journal article, 2017)Alginates are polysaccharides that are widely used in relation to their ability to form gels. Recently we reported that alginates may also form gels with chitosan oligomers as crosslinkers (Khong, Aarstad, Skjåk-Bræk, ... -
Alternatives to mammalian gelatin for lipid-based drug and nutraceutical delivery; formulation and characterisation of fish gelatin-, agar- and pectin-based chewable emulsion gels
Arntsen, Stine Wold (Master thesis, 2022)Abstract will be available on 2024-05-31 -
Bioactively filled gelatin gels; challenges and opportunities
Dille, Morten Johnsen; Hattrem, Magnus Nergård; Draget, Kurt Ingar (Journal article; Peer reviewed, 2016)Soft, chewable gelatin matrices represent an excellent alternative to traditional oral administration forms (tablets, soft and hard capsules) for pharma- and nutraceuticals; especially for the pediatric and geriatric ... -
Biosimilar Mucus as a Model System for Small Intestinal Mucus: -Evaluating the Applicability for Nanoparticle Drug Delivery Studies
Våset, Frida Sandvik (Master thesis, 2014)Slimhinnene i mage/tarm, luftveier og urogenitaliene er store mål for legemiddellevering i kroppen. Mucus blir uskilt fra slimhinnene og kan skape en barriere når legemidler i form av biologiske makromolekyler skal ... -
Calcium binding and calcium-induced gelation of normal low-methoxyl pectin modified by low molecular-weight polyuronate fraction
Nakauma, Makoto; Funami, Takahiro; Fang, Yapeng; Nishinari, Katsuyoshi; Draget, Kurt Ingar; Phillips, Glyn O. (Journal article, 2017)Functions of low molecular-weight polyuronate fractions in the calcium binding and calcium-induced gelation of normal low-methoxyl pectin (LMP) were investigated. The fractions from pectin with two different degrees of ... -
Characterisation of a novel gelatin-based system for oral delivery of pharmaceuticals and nutraceuticals
Dysvik, Anna (Master thesis, 2015)Abstract Oral delivery is one of the most utilized routes for pharmaceutical delivery, due to its simplicity, convenience and thoroughly evaluated safety-profile. Significant drawbacks are however associated with ... -
Characterization and Properties of Hydrogels Made from Neutral Soluble Chitosans
Franzen, Henry M; Draget, Kurt Ingar; Langebäck, Joakim; Nilsen-Nygaard, Julie (Journal article; Peer reviewed, 2015)The current paper focuses on the preparation and some characteristics of viscoelastic hydrogels, ViscoGels™, made from chitosans having a random acylation pattern. Three different chitosan batches with a high fraction of ... -
Chemical and structural composition of gelatine extracted from defatted Atlantic salmon (Salmo salar) skin
Fossen, Evelyn H. (Master thesis, 2020)Atlanterhavslaks (Salmo salar) er en av de viktigste fiskeartene i havbruk. Store mengder restråstoff oppstår under prosessering, og disse kan inneholde verdifulle komponenter som enten forblir uutnyttet eller blir utnyttet ... -
Chitosan: Gels and interfacial properties
Nilsen-Nygaard, Julie; Strand, Sabina P.; Vårum, Kjell Morten; Draget, Kurt Ingar; Nordgård, Catherine Taylor (Journal article; Peer reviewed, 2015)Chitosan is a unique biopolymer in the respect that it is abundant, cationic, low-toxic, non-immunogenic and biodegradable. The relative occurrence of the two monomeric building units (N-acetyl-glucosamine and d-glucosamine) ... -
Co association of mucus modulating agents and nanoparticles for mucosal drug delivery
Nordgård, Catherine Taylor; Draget, Kurt Ingar (Journal article; Peer reviewed, 2018)Nanoparticulate drug delivery systems (nDDS) offer a variety of options when it comes to routes of administration. One possible path is crossing mucosal barriers, such as in the airways and in the GI tract, for systemic ... -
Confocal reflectance microscopy and multiple particle tracking for the study of the gelation of biopolymers
Haug, Bente; Nordgård, Catherine Taylor; Draget, Kurt Ingar; Bjørkøy, Astrid (Journal article; Peer reviewed, 2018)The combination of confocal reflectance imaging (CRM) and simultaneous multiple particle tracking (MPT) with mean-square displacement (MSD) analysis is a new method for studying the gelation of biopolymers. In addition to ... -
Direct Determination of Chitosan–Mucin Interactions Using a Single-Molecule Strategy: Comparison to Alginate–Mucin Interactions
Haugstad, Kristin Elisabeth; Håti, Armend Gazmeno; Nordgård, Catherine Taylor; Adl, Patricia S.; Maurstad, Gjertrud; Sletmoen, Marit; Draget, Kurt Ingar; Dias, Rita de Sousa; Stokke, Bjørn Torger (Journal article; Peer reviewed, 2015)Aqueous chitosan possesses attractive interaction capacities with various molecular groups that can be involved in hydrogen bonds and electrostatic and hydrophobic interactions. In the present paper, we report on the direct ... -
Drug Delivery Using Oral Vehicles: Controlled Release in the GI-tract
Sæther, Maren (Master thesis, 2012)Oral delivery is considered a convenient route for administration of pharmaceuticals. Great effort has been made to optimize oral delivery vehicles to increase the bioavailability of the pharmaceutical, and enhance patient ... -
Enzyminhibering av guluronatoligomere i farmasøytiske applikasjoner
Røyrvik, Brita (Master thesis, 2011)Alginat har en lang tradisjon som en allsidig marin ressurs. Det har i en årrekke blitt forsket på mulige anvendelser av alginat. Alginatets gelingsevne er den egenskapen som for det meste er blitt utnyttet. I de senere ... -
Extracellular matrix modifications by oligoguluronates for cancer treatment
Haug, Bente (Master thesis, 2018)Type I collagen is the main structural protein of the extracellular matrix, and is abnormally produced in many types of solid tumours. The presence of a thick and linearised collagen fibres constituting a dense network in ... -
Gels and gelled emulsions prepared by acid-induced gelation of mixtures of faba bean (Vicia faba) protein concentrate and λ-carrageenan
Dille, Morten Johnsen; Knutsen, Svein Halvor; Draget, Kurt Ingar (Journal article, 2022)In this study, gels were successfully prepared at room temperature from mixtures of dry fractionated faba bean protein concentrate (FPC) and λ-carrageenan (λ-CGN), through acidification with glucono-δ-lactone (GDL). At ... -
Ibuprofen-in-cyclodextrin-in-W/O/W emulsion - Improving the initial and long-term encapsulation efficiency of a model active ingredient.
Hattrem, Magnus; Kristiansen, Kåre Andre; Aachmann, Finn Lillelund; Dille, Morten Johnsen; Draget, Kurt Ingar (Journal article; Peer reviewed, 2015)A challenge in formulating water-in-oil-in-water (W/O/W) emulsions is the uncontrolled release of the encapsulated compound prior to application. Pharmaceuticals and nutraceuticals usually have amphipathic nature, which ... -
Investigation of the diffusion barrier properties in mixtures of mammalian and cold-water fish gelatin
Landsem, Kristoffer Gustad (Master thesis, 2023)Diffusjonsbarriereegenskapene til en gel er en av flere viktige faktorer som bidrar til å definere oppførselen og funksjonaliteten til den. Gelatin er en av mange geleringsmiddel som er vidt brukt i industrien i dag, og ...