Browsing NTNU Open by Author "Drabløs, Finn Sverre"
Now showing items 1-9 of 9
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A balanced tissue composition reveals new metabolic and gene expression markers in prostate cancer
Tessem, May-Britt; Bertilsson, Helena; Angelsen, Anders; Bathen, Tone Frost; Drabløs, Finn Sverre; Rye, Morten Beck (Journal article; Peer reviewed, 2016)Molecular analysis of patient tissue samples is essential to characterize the in vivo variability in human cancers which are not accessible in cell-lines or animal models. This applies particularly to studies of tumor ... -
A novel non-canonical Wnt signature for prostate cancer aggressiveness
Sandsmark, Elise; Hansen, Ailin Falkmo; Selnæs, Kirsten Margrete; Bertilsson, Helena; Bofin, Anna M.; Wright, Alan J.; Viset, Trond; Richardsen, Elin; Drabløs, Finn Sverre; Bathen, Tone Frost; Tessem, May-Britt; Rye, Morten Beck (Journal article; Peer reviewed, 2016)Activation of the Canonical Wnt pathway (CWP) has been linked to advanced and metastatic prostate cancer, whereas the Wnt5a-induced non-canonical Wnt pathway (NCWP) has been associated with both good and poor prognosis. A ... -
Detection of germline variants with pathogenic potential in 48 patients with familial colorectal cancer by using whole exome sequencing
Singh, Ashish Kumar; Talseth-Palmer, Bente Anita; Xavier, Alexandre; Scott, Rodney J.; Drabløs, Finn Sverre; Sjursen, Wenche (Peer reviewed; Journal article, 2023)Background Hereditary genetic mutations causing predisposition to colorectal cancer are accountable for approximately 30% of all colorectal cancer cases. However, only a small fraction of these are high penetrant mutations ... -
EpiFactors 2022: expansion and enhancement of a curated database of human epigenetic factors and complexes
Marakulina, Daria; Vorontsov, Ilya E.; Kulakovskiy, Ivan V.; Lennartsson, Andreas; Drabløs, Finn Sverre; Medvedeva, Yulia A. (Journal article; Peer reviewed, 2023) -
Feature-based classification of human transcription factors into hypothetical sub-classes related to regulatory function.
Ehsani, Rezvan; Bahrami, Shahram; Drabløs, Finn Sverre (Peer reviewed; Journal article, 2016)Background Transcription factors are key proteins in the regulation of gene transcription. An important step in this process is the opening of chromatin in order to make genomic regions available for transcription. Data ... -
Pathway Analysis of Skin from Psoriasis Patients after Adalimumab Treatment Reveals New Early Events in the Anti-Inflammatory Mechanism of Anti-TNF-α
Langkilde, Ane; Olsen, Lene Christin; Sætrom, Pål; Drabløs, Finn Sverre; Besenbacher, Søren; Raaby, Line; Johansen, Claus; Iversen, Lars (Peer reviewed; Journal article, 2016)Psoriasis is a chronic cutaneous inflammatory disease. The immunopathogenesis is a complex interplay between T cells, dendritic cells and the epidermis in which T cells and dendritic cells maintain skin inflammation. ... -
TopoICSim: A new semantic similarity measure based on gene ontology
Ehsani, Rezvan; Drabløs, Finn Sverre (Peer reviewed; Journal article, 2016)Background The Gene Ontology (GO) is a dynamic, controlled vocabulary that describes the cellular function of genes and proteins according to tree major categories: biological process, molecular function and cellular ... -
Update of the FANTOM web resource: high resolution transcriptome of diverse cell types in mammals
Lizio, Marina; Harshbarger, Jayson; Abugessaisa, Imad; Noguchi, Shuei; Kondo, Atsushi; Severin, Jessica; Mungall, Chris; Arenillas, David; Mathelier, Anthony; Medvedeva, Yulia; Lennartsson, Andreas; Drabløs, Finn Sverre; Ramilowski, Jordan; Rackham, Owen; Gough, Julian; Andersson, Robin; Sandelin, Albin; Ienasescu, Hans; Ono, Hiromasa; Bono, Hidemasa; Hayashizaki, Yoshihide; Carninci, Piero; Forrest, Alistair R.R.; Kasukawa, Takeya; Kawaji, Hideya (Journal article; Peer reviewed, 2017)Upon the first publication of the fifth iteration of the Functional Annotation of Mammalian Genomes collaborative project, FANTOM5, we gathered a series of primary data and database systems into the FANTOM web resource ... -
Use of multigene-panel identifies pathogenic variants in several CRC-predisposing genes in patients previously tested for Lynch Syndrome
Hansen, Maren; Johansen, Jostein; Sylvander, Anna Elisabeth; Bjørnevoll, Inga; Talseth-Palmer, Bente Anita; Lavik, Liss Ane; Xavier, Alexandre; Engebretsen, Lars Fredri; Scott, Rodney; Drabløs, Finn Sverre; Sjursen, Wenche (Journal article; Peer reviewed, 2017)Background Many families with a high burden of colorectal cancer fulfil the clinical criteria for Lynch Syndrome. However, in about half of these families, no germline mutation in the mismatch repair genes known to be ...