• A balanced tissue composition reveals new metabolic and gene expression markers in prostate cancer 

      Tessem, May-Britt; Bertilsson, Helena; Angelsen, Anders; Bathen, Tone Frost; Drabløs, Finn Sverre; Rye, Morten Beck (Journal article; Peer reviewed, 2016)
      Molecular analysis of patient tissue samples is essential to characterize the in vivo variability in human cancers which are not accessible in cell-lines or animal models. This applies particularly to studies of tumor ...
    • A novel non-canonical Wnt signature for prostate cancer aggressiveness 

      Sandsmark, Elise; Hansen, Ailin Falkmo; Selnæs, Kirsten Margrete; Bertilsson, Helena; Bofin, Anna M.; Wright, Alan J.; Viset, Trond; Richardsen, Elin; Drabløs, Finn Sverre; Bathen, Tone Frost; Tessem, May-Britt; Rye, Morten Beck (Journal article; Peer reviewed, 2016)
      Activation of the Canonical Wnt pathway (CWP) has been linked to advanced and metastatic prostate cancer, whereas the Wnt5a-induced non-canonical Wnt pathway (NCWP) has been associated with both good and poor prognosis. A ...
    • Feature-based classification of human transcription factors into hypothetical sub-classes related to regulatory function. 

      Ehsani, Rezvan; Bahrami, Shahram; Drabløs, Finn Sverre (Peer reviewed; Journal article, 2016)
      Background Transcription factors are key proteins in the regulation of gene transcription. An important step in this process is the opening of chromatin in order to make genomic regions available for transcription. Data ...
    • Pathway Analysis of Skin from Psoriasis Patients after Adalimumab Treatment Reveals New Early Events in the Anti-Inflammatory Mechanism of Anti-TNF-α 

      Langkilde, Ane; Olsen, Lene Christin; Sætrom, Pål; Drabløs, Finn Sverre; Besenbacher, Søren; Raaby, Line; Johansen, Claus; Iversen, Lars (Peer reviewed; Journal article, 2016)
      Psoriasis is a chronic cutaneous inflammatory disease. The immunopathogenesis is a complex interplay between T cells, dendritic cells and the epidermis in which T cells and dendritic cells maintain skin inflammation. ...
    • TopoICSim: A new semantic similarity measure based on gene ontology 

      Ehsani, Rezvan; Drabløs, Finn Sverre (Peer reviewed; Journal article, 2016)
      Background The Gene Ontology (GO) is a dynamic, controlled vocabulary that describes the cellular function of genes and proteins according to tree major categories: biological process, molecular function and cellular ...
    • Update of the FANTOM web resource: high resolution transcriptome of diverse cell types in mammals 

      Lizio, Marina; Harshbarger, Jayson; Abugessaisa, Imad; Noguchi, Shuei; Kondo, Atsushi; Severin, Jessica; Mungall, Chris; Arenillas, David; Mathelier, Anthony; Medvedeva, Yulia; Lennartsson, Andreas; Drabløs, Finn Sverre; Ramilowski, Jordan; Rackham, Owen; Gough, Julian; Andersson, Robin; Sandelin, Albin; Ienasescu, Hans; Ono, Hiromasa; Bono, Hidemasa; Hayashizaki, Yoshihide; Carninci, Piero; Forrest, Alistair R.R.; Kasukawa, Takeya; Kawaji, Hideya (Journal article; Peer reviewed, 2017)
      Upon the first publication of the fifth iteration of the Functional Annotation of Mammalian Genomes collaborative project, FANTOM5, we gathered a series of primary data and database systems into the FANTOM web resource ...
    • Use of multigene-panel identifies pathogenic variants in several CRC-predisposing genes in patients previously tested for Lynch Syndrome 

      Hansen, Maren; Johansen, Jostein; Sylvander, Anna Elisabeth; Bjørnevoll, Inga; Talseth-Palmer, Bente Anita; Lavik, Liss Ane; Xavier, Alexandre; Engebretsen, Lars Fredri; Scott, Rodney; Drabløs, Finn Sverre; Sjursen, Wenche (Journal article; Peer reviewed, 2017)
      Background Many families with a high burden of colorectal cancer fulfil the clinical criteria for Lynch Syndrome. However, in about half of these families, no germline mutation in the mismatch repair genes known to be ...