Browsing NTNU Open by Author "Davey-Smith, George"

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    • HMG-CoA reductase is a potential therapeutic target for migraine: a mendelian randomization study 

      Qu, Kang; Li, Ming-Xi; Yu, Peng; Palotie, Aarno; Pressman, Alice; Belin, Andrea C.; Bjornsdottir, Anna; van den Maagdenberg, Arn M. J. M.; Harder, Aster V. E.; Winsvold, Bendik Kristoffer Slagsvold; Müller-Myhsok, Bertram; Cormand, Bru; Ran, Caroline; Northover, Carrie; Kubisch, Christian; van Duijn, Cornelia; Nyholt, Dale R.; Chasman, Daniel I.; Posthuma, Danielle; Lessel, Davor; Boomsma, Dorret I.; Hämäläinen, Eija; Kristoffersen, Espen Saxhaug; Cuenca-Leon, Ester; Davey-Smith, George; Terwindt, Gisela M.; Sigurdardottir, Gudrun R.; Bjornsdottir, Gyda; Hautakangas, Heidi; Stefansson, Hreinn; de Boer, Irene; Kaprio, Jaakko; Olesen, Jes; Zwart, John Anker Henrik; Stefansson, Kari; Ligthart, Lannie; Launer, Lenore; Pedersen, Linda Margareth; Kogelman, Lisette J. A.; Griffiths, Lyn R.; Ikram, M. Arfan; Wessman, Maija; Kaunisto, Mari; Hrafnsdottir, Maria G.; Hiekkala, Marjo; Järvelin, Marjo-Riitta; Dichgans, Martin; Pirinen, Matti; Kallela, Mikko; Kurki, Mitja; Chalmer, Mona A.; Pedersen, Nancy; Sveinsson, Olafur A.; Raitakari, Olli; Gormley, Padhraig; Pozo-Rosich, Patricia; Palta, Priit; Malik, Rainer; Kajanne, Risto; Børte, Sigrid; Magnusson, Sigurdur H.; Lehtimäki, Terho; Hansen, Thomas F; Thorgeirsson, Thorgeir E.; Freilinger, Tobias; Kurth, Tobias; Esko, Tonu; Anttila, Verneri; Artto, Ville; Wu, Bai-Hua; Shi, Miao; Dong, Ming (Peer reviewed; Journal article, 2024)
      Statins are thought to have positive effects on migraine but existing data are inconclusive. We aimed to evaluate the causal effect of such drugs on migraines using Mendelian randomization. We used four types of genetic ...

    • Population phenomena inflate genetic associations of complex social traits 

      Morris, Tim T; Davies, Neil Martin; Hemani, Gibran; Davey-Smith, George (Peer reviewed; Journal article, 2020)
      Heritability, genetic correlation, and genetic associations estimated from samples of unrelated individuals are often perceived as confirmation that genotype causes the phenotype(s). However, these estimates can arise from ...