Blar i NTNU Open på forfatter "Dajani, Olav"
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Appetite and dietary intake endpoints in cancer cachexia clinical trials: Systematic Review 2 of the cachexia endpoints series
Vagnildhaug, Ola Magne; Balstad, Trude Rakel; Ottestad, Inger; Bye, Asta; Greil, Christine; Arends, Jann; Baracos, Vickie; Brown, Leo R.; Dajani, Olav; Dolan, Ross D.; Fallon, Marie; Fraser, Eilidh; Grzyb, Aleksandra; Hjermstad, Marianne Jensen; Jakobsen, Gunnhild; Kaasa, Stein; McDonald, James; Philips, Iain; Sayers, Judith; Simpson, Melanie Rae; Sousa, Mariana S.; Skipworth, Richard J.E.; Laird, Barry J.A.; Solheim, Tora S (Journal article; Peer reviewed, 2024)There is no consensus on the optimal endpoint(s) in cancer cachexia trials. Endpoint variation is an obstacle when comparing interventions and their clinical value. The aim of this systematic review was to summarize and ... -
Biomarker endpoints in cancer cachexia clinical trials: Systematic Review 5 of the cachexia endpoint series
Yule, Michael S.; Thompson, Joshua; Leesahatsawat, Khachonphat; Sousa, Mariana S.; Anker, Stefan D.; Arends, Jann; Balstad, Trude Rakel; Brown, Leo R.; Bye, Asta; Dajani, Olav; Fallon, Marie; Hjermstad, Marianne Jensen; Jakobsen, Gunnhild; McDonald, James; McGovern, Josh; Roeland, Eric J.; Sayers, Judith; Skipworth, Richard J.E.; Ottestad, Inger; Philips, Iain; Simpson, Melanie Rae; Solheim, Tora S; Vagnildhaug, Ola Magne; McMillan, Donald; Laird, Barry J; Dolan, Ross D. (Journal article; Peer reviewed, 2024)Regulatory agencies require evidence that endpoints correlate with clinical benefit before they can be used to approve drugs. Biomarkers are often considered surrogate endpoints. In cancer cachexia trials, the measurement ... -
Body weight and composition endpoints in cancer cachexia clinical trials: Systematic Review 4 of the cachexia endpoints series
Brown, Leo R.; Sousa, Mariana S.; Yule, Michael S.; Baracos, Vickie E.; McMillan, Donald C.; Arends, Jann; Balstad, Trude Rakel; Bye, Asta; Dajani, Olav; Dolan, Ross D.; Fallon, Marie T.; Greil, Christine; Hjermstad, Marianne Jensen; Jakobsen, Gunnhild; Maddocks, Matthew; McDonald, James; Ottestad, Inger; Phillips, Iain; Sayers, Judith; Simpson, Melanie Rae; Vagnildhaug, Ola Magne; Solheim, Tora S; Laird, Barry J; Skipworth, Richard J.E. (Journal article; Peer reviewed, 2024)Significant variation exists in the outcomes used in cancer cachexia trials, including measures of body composition, which are often selected as primary or secondary endpoints. To date, there has been no review of the most ... -
Comparing two Classifications of Cancer Cachexia and Their Association with Survival in Patients with Unresected Pancreatic Cancer
Wesseltoft-Rao, Nima; Hjermstad, Marianne Jensen; Andersen, Tone Ikdahl; Dajani, Olav; Ulven, Stine Marie; Iversen, Per Ole; Bye, Asta (Journal article; Peer reviewed, 2015)There is no universally accepted definition of cancer cachexia. Two classifications have been proposed; the 3-factor classification requiring ≥2 of 3 factors; weight loss ≥10%, food intake ≤1500 kcal/day, and C-reactive ... -
PALLiative care in ONcology (PALLiON): A cluster-randomised trial investigating the effect of palliative care on the use of anticancer treatment at the end of life
Hjermstad, Marianne Jensen; Pirnat, Aleksandra; Aass, Nina Kathrine; Andersen, Sigve; Astrup, Guro Lindviksmoen; Dajani, Olav; Garresori, Herish; Guldhav, Kristin Vassbotn; Hamre, Hanne Mari; Haukland, Ellinor Christin; Jordal, Frode; Lundeby, Tonje; Løhre, Erik Torbjørn; Mjåland, Svein; Paulsen, Ørnulf; Semb, Karin; Staff, Erik Schistad; Wester, Torunn Elin; Kaasa, Stein (Journal article; Peer reviewed, 2024)Background: Effects on anticancer therapy following the integration of palliative care and oncology are rarely investigated. Thus, its potential effect is unknown. Aim: To investigate the effects of the complex intervention ... -
PALLiON - PALLiative care Integrated in ONcology: Study protocol for a Norwegian national cluster-randomized control trial with a complex intervention of early integration of palliative care
Hjermstad, Marianne Jensen; Aass, Nina Kathrine; Andersen, Sigve; Brunelli, Cinzia; Dajani, Olav; Ahmed, Herish; Hamre, Hanne Mari; Haukland, Ellinor Christin; Holmberg, Mats; Jordal, Frode; Krogstad, Hilde; Lundeby, Tonje; Løhre, Erik T; Mjåland, Svein; Nordbø, Arve; Paulsen, Ørnulf; Staff, Erik Schistad; Wester, Torunn; Kaasa, Stein; Loge, Jon Håvard (Peer reviewed; Journal article, 2020)Background - Several publications have addressed the need for a systematic integration of oncological care focused on the tumor and palliative care (PC) focused on the patient with cancer. The exponential increase in ... -
Physical function endpoints in cancer cachexia clinical trials: Systematic Review 1 of the cachexia endpoints series
McDonald, James; Sayers, Judith; Anker, Stefan D.; Arends, Jann; Balstad, Trude Rakel; Baracos, Vickie; Brown, Leo; Bye, Asta; Dajani, Olav; Dolan, Ross; Fallon, Marie T.; Fraser, Eilidh; Griel, Christine; Grzyb, Aleksandra; Hjermstad, Marianne Jensen; Jamal-Hanjani, Mariam; Jakobsen, Gunnhild; Kaasa, Stein; McMillan, Donald; Maddocks, Matthew; Philips, Iain; Ottestad, Inger; Reid, Kieran F.; Sousa, Mariana S.; Simpson, Melanie Rae; Vagnildhaug, Ola Magne; Skipworth, Richard J. E.; Solheim, Tora S; Laird, Barry J (Peer reviewed; Journal article, 2023)In cancer cachexia trials, measures of physical function are commonly used as endpoints. For drug trials to obtain regulatory approval, efficacy in physical function endpoints may be needed alongside other measures. However, ... -
Quality of life endpoints in cancer cachexia clinical trials: Systematic review 3 of the cachexia endpoints series
Hjermstad, Marianne Jensen; Jakobsen, Gunnhild; Arends, Jann; Balstad, Trude Rakel; Brown, Leo R.; Bye, Asta; Coats, Andrew J.S.; Dajani, Olav; Dolan, Ross D.; Fallon, Marie T.; Greil, Christine; Grzyb, Alexandra; Kaasa, Stein; Koteng, Lisa Heide; May, Anne M.; McDonald, James; Ottestad, Inger; Philips, Iain; Roeland, Eric J.; Sayers, Judith; Simpson, Melanie Rae; Skipworth, Richard J.E.; Solheim, Tora S; Sousa, Mariana S.; Vagnildhaug, Ola Magne; Laird, Barry J.A. (Journal article; Peer reviewed, 2024)The use of patient-reported outcomes (PROMs) of quality of life (QOL) is common in cachexia trials. Patients' self-report on health, functioning, wellbeing, and perceptions of care, represent important measures of efficacy. ...