Browsing NTNU Open by Author "Busche, Tobias"
Now showing items 1-5 of 5
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Class IV lasso peptides synergistically induce proliferation of cancer cells and sensitize them to doxorubicin
Madland, Eva; Felipe Guerrero-Garzón, Jaime; Zehl, Martin; Singh, Madhurendra; Rezaei, Shiva; Aachmann, Finn Lillelund; Courtade, Gaston; Urban, Ernst; Rückert, Christian; Busche, Tobias; Kalinowski, Jörn; Cao, Yan-Ru; Jiang, Yi; Jiang, Cheng-lin; Selivanova, Galina; Zotchev, Sergey (Peer reviewed; Journal article, 2020)Heterologous expression of a biosynthesis gene cluster from Amycolatopsis sp. resulted in the discovery of two unique class IV lasso peptides, felipeptins A1 and A2. A mixture of felipeptins stimulated proliferation of ... -
Coupling of the engineered DNA “mutator” to a biosensor as a new paradigm for activation of silent biosynthetic gene clusters in Streptomyces
Sekurova, Olga N.; Sun, Yi-Qian; Zehl, Martin; Rückert, Christian; Stich, Anna; Busche, Tobias; Kalinowski, Jörn; Zotchev, Sergey B. (Journal article; Peer reviewed, 2021) -
Development of a Biosensor Concept to Detect the Production of Cluster-Specific Secondary Metabolites
Sun, Yi-Qian; Busche, Tobias; Rückert, Christian; Paulus, Constanze; Rebets, Yuriy; Novakova, Renata; Kalinowski, Jörn; Luzhetskyy, Andriy; Kormanec, Jan; Sekurova, Olga N.; Zotchev, Sergey B. (Journal article; Peer reviewed, 2017)Genome mining of actinomycete bacteria aims at the discovery of novel bioactive secondary metabolites that can be developed into drugs. A new repressor-based biosensor to detect activated secondary metabolite biosynthesis ... -
Genomic and Transcriptomic Investigation of the Physiological Response of the Methylotroph Bacillus methanolicus to 5-Aminovalerate
Haupka, Carsten; Fernandes de Brito, Luciana; Busche, Tobias; Wibberg, Daniel; Wendisch, Volker F. (Peer reviewed; Journal article, 2021)The methylotrophic thermophile Bacillus methanolicus can utilize the non-food substrate methanol as its sole carbon and energy source. Metabolism of L-lysine, in particular its biosynthesis, has been studied to some detail, ... -
Long-term microbial community structures and dynamics in a commercial RAS during seven production batches of Atlantic salmon fry (Salmo salar)
Dahle, Stine Veronica Wiborg; Gaarden, Sunniva Ingebrigtsen; Buhaug, Julia Fossberg; Netzer, Roman; Attramadal, Kari; Busche, Tobias; Aas, Marianne; Ribicic, Deni; Bakke, Ingrid (Peer reviewed; Journal article, 2023)The microbiota of recirculating aquaculture systems (RAS) is of major importance for optimal fish health. However, the microbial communities in commercial RAS are highly complex and more knowledge is needed to potentially ...