Blar i NTNU Open på forfatter "Brumpton, Ben Michael"

Viser treff 1-20 av 97

    • Adiposity and asthma in adults: a bidirectional Mendelian randomization analysis of the HUNT Study 

      Sun, Yi-Qian; Brumpton, Ben Michael; Langhammer, Arnulf; Chen, Yue; Kvaløy, Kirsti; Mai, Xiao-Mei (Journal article; Peer reviewed, 2019)
      Background We aimed to investigate the potential causal associations of adiposity with asthma overall, asthma by atopic status or by levels of symptom control in a large adult population and stratified by sex. We also ...

    • Age at Menarche, age at Natural Menopause, and Risk of Lung and Colorectal Cancers: A Mendelian Randomization Study 

      Dénos, Marion Nicole Marie; Sun, Yi-Qian; Jiang, Lin; Brumpton, Ben Michael; Mai, Xiao-Mei (Peer reviewed; Journal article, 2023)
      Background: The roles of age at menarche and age at menopause in the etiology of lung and colorectal cancers are unclear. Objective: We aimed to investigate potential causal associations between age at menarche, age at ...

    • Age-of-onset information helps identify 76 genetic variants associated with allergic disease 

      Ferreira, Manuel A R; Vonk, Judith M.; Baurecht, Hansjörg; Marenholz, Ingo; Tian, Chao; Hoffman, Joshua D.; Helmer, Quinta; Tillander, Annika; Ullemar, Vilhelmina; Lu, Yi; Grosche, Sarah; Ruschendorf, Franz; Granell, Raquel; Brumpton, Ben Michael; Fritsche, Lars; Bhatta, Laxmi; Gabrielsen, Maiken Elvestad; Nielsen, Jonas Bille; Zhou, Wei; Hveem, Kristian; Langhammer, Arnulf; Holmen, Oddgeir; Løset, Mari; Abecasis, Goncalo; Willer, Cristen J.; Emami, Nima C.; Cavazos, Taylor B.; Witte, John S.; Szwajda, Agnieszka; 23andMe Research Team, ,; collaborators of SHARE study, ,; Hinds, David A.; Hubner, Norbert; Weidinger, Stephan; Magnusson, Patrik KE; Jorgenson, Eric; Karlsson, Robert; Paternoster, Lavinia; Boomsma, Dorret I.; Almqvist, Catarina; Lee, Young-Ae; Koppelman, Gerard H.; Esparza-Gordillo, Jorge; Hummel, Oliver; Hottenga, Jouke-Jan; Willemsen, Gonneke; Rodríguez, Elke; Hotze, Melanie; Franke, Andre; Matheson, Melanie C.; Dharmage, Shyamali Chandrika; Arnold, Andreas; Homuth, Georg; Schmidt, Carsten O; Thompson, Philip J.; Martin, Nicholas G; Duffy, David L.; Novak, Natalija; Schulz, Holger; Karrasch, Stefan; Gieger, Christian; Strauch, Konstantin; Melles, Ronald B (Peer reviewed; Journal article, 2020)
      Risk factors that contribute to inter-individual differences in the age-of-onset of allergic diseases are poorly understood. The aim of this study was to identify genetic risk variants associated with the age at which ...

    • ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma 

      Praveen, Kavita; Patel, Gaurang C.; Gurski, Lauren; Ayer, Ariane H.; Persaud, Trikaladarshi; Still, Matthew D.; Miloscio, Lawrence; Van Zyl, Tavé; Di Gioia, Silvio Alessandro; Brumpton, Ben Michael; Krebs, Kristine; Åsvold, Bjørn Olav; Chen, Esteban; Chavali, Venkata R M; Fury, Wen; Gudiseva, Harini V.; Hyde, Sarah; Jorgenson, Eric; Lefebvre, Stephanie; Li, Dadong; Li, Alexander; Mclninch, James; Patel, Brijeshkumar; Rabinowitz, Jeremy S.; Salowe, Rebecca; Schurmann, Claudia; Seidelin, Anne-Sofie; Stahl, Eli; Sun, Dylan; Teslovich, Tanya M.; Tybjærg-Hansen, Anne; Willer, Cristen; Waldron, Scott; Walley, Sabrina; Yang, Hua; Zaveri, Sarthak; Hu, Ying; Hveem, Kristian; Melander, Olle; Milani, Lili; Stender, Stefan; O'Brien, Joan M.; Jones, Marcus B.; Abecasis, Gonçalo R; Cantor, Michael N.; Weyne, Jonathan; Karalis, Katia; Economides, Aris; Della Gatta, Giusy; Ferreira, Manuel A.; Yancopoulos, George D.; Baras, Aris; Romano, Carmelo; Coppola, Giovanni (Peer reviewed; Journal article, 2022)
      Glaucoma is a leading cause of blindness. Current glaucoma medications work by lowering intraocular pressure (IOP), a risk factor for glaucoma, but most treatments do not directly target the pathological changes leading ...

    • Aptamer-Based Proteomic Platform Identifies Novel Protein Predictors of Incident Heart Failure and Echocardiographic Traits 

      Nayor, Matthew; Short, Meghan I.; Rasheed, Humaira; Lin, Honghuang; Jonasson, Christian; Yang, Qiong; Hveem, Kristian; Felix, Janine F.; Morrison, Alanna C.; Wild, Philipp S.; Morley, Michael P.; Cappola, Thomas P.; Benson, Mark D.; Ngo, Debby; Sinha, Sumita; Keyes, Michelle J.; Shen, Dongxiao; Wang, Thomas J.; Larson, Martin G.; Brumpton, Ben Michael; Gerszten, Robert E.; Omland, Torbjørn; Vasan, Ramachandran S. (Peer reviewed; Journal article, 2020)
      Abstract Background: We used a large-scale, high-throughput DNA aptamer-based discovery proteomic platform to identify circulating biomarkers of cardiac remodeling and incident heart failure (HF) in community-dwelling ...

    • Assessing short-term risk of ischemic stroke in relation to all prescribed medications 

      Janszky, Imre; Vardaxis, Ioannis; Lindqvist, Bo Henry; Horn, Jens; Brumpton, Ben Michael; Strand, Linn Beate; Bakken, Inger Johanne Landsjøåsen; Alsnes, Ingvild Vatten; Romundstad, Pål Richard; Ljung, Rickard; Mukamal, Kenneth J.; Sen, Abhijit (Peer reviewed; Journal article, 2021)
      We examined the short-term risk of stroke associated with drugs prescribed in Norway or Sweden in a comprehensive, hypothesis-free manner using comprehensive nation-wide data. We identified 27,680 and 92,561 cases with a ...

    • The association between normal lung function and peak oxygen uptake in patients with exercise intolerance and coronary artery disease 

      Rasch-Halvorsen, Øystein; Hassel, Erlend; Brumpton, Ben Michael; Jenssen, Haldor; Spruit, Martijn A.; Langhammer, Arnulf; Steinshamn, Sigurd Loe (Peer reviewed; Journal article, 2020)
      In coronary artery disease (CAD), exercise intolerance with reduced oxygen uptake at peak exercise (VO2peak) is assumed to primarily reflect cardiovascular limitation. However, oxygen transport and utilization depends on ...

    • Associations of asthma and asthma control with atrial fibrillation risk: Results from the Nord-Trøndelag health study (HUNT) 

      Cepelis, Aivaras; Brumpton, Ben Michael; Malmo, Vegard; Laugsand, Lars Erik; Loennechen, Jan Pål; Ellekjær, Hanne; Langhammer, Arnulf; Janszky, Imre; Strand, Linn B (Journal article; Peer reviewed, 2018)
      Importance Asthma, a chronic inflammatory airway disease, and atrial fibrillation (AF) share several common pathophysiological mechanisms. Research on the association between asthma and atrial fibrillation is lacking, ...

    • Asthma and asthma symptom control in relation to incidence of lung cancer in the HUNT study 

      Jiang, Lin; Sun, Yi-Qian; Langhammer, Arnulf; Brumpton, Ben Michael; Chen, Yu; Nilsen, Tom Ivar Lund; Leivseth, Linda; Wahl, Sissel Gyrid Freim; Mai, Xiao-Mei (Peer reviewed; Journal article, 2021)
      Large prospective studies on asthma, especially asthma symptom control, as a potential risk factor for lung cancer are limited. We followed up 62,791 cancer-free Norwegian adults from 1995–1997 to 2017. Self-reported ...

    • Asthma, asthma control and risk of ischemic stroke: The HUNT study 

      Cepelis, Aivaras; Brumpton, Ben Michael; Laugsand, Lars Erik; Langhammer, Arnulf; Janszky, Imre; Strand, Linn B (Journal article; Peer reviewed, 2019)
      Background: Asthma, a chronic inflammatory airway disease, shares common pathophysiological mechanisms with ischemic stroke. The aim of the study is to assess the association between asthma, levels of asthma control and ...

    • Asthma, asthma control and the risk of cardiovascular disease - The Nord-Trøndelag Health Study (HUNT) 

      Cepelis, Aivaras (Doctoral theses at NTNU;2020:121, Doctoral thesis, 2020)
      Norsk sammendrag Astma, en kronisk inflammatorisk luftveissykdom, rammer så mange som 30 millioner barn og voksne i Europa. Utbredelsen av astma er omtrent 10% i det nordlige og vestlige Europa og har doblet seg de siste ...

    • Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses 

      Brumpton, Ben Michael; Sanderson, Eleanor; Heilbron, Karl; Hartwig, FP; Harrison, S; Vie, Gunnhild Åberge; Cho, Y; Howe, LD; Hughes, A; Boomsma, D; Havdahl, Alexandra; Hopper, J; Neale, M; Nivard, Michel G.; Pedersen, N; Reynolds, CA; Tucker-D, EM; Grotzinger, A; Howe, Laurence; Morris, Tim; Li, Shuai; Within-Family Consortium, The; 23andMe Research Team, The; Auton, A; Windmeijer, F; Chen, W-M; Bjørngaard, Johan Håkon; Hveem, Kristian; Willer, C; Evans, DM; Kaprio, J; Davey Smith, G; Åsvold, BO; Åsvold, Bjørn Olav; Hemani, G; Davies, Neil Martin (Peer reviewed; Journal article, 2020)
      Estimates from Mendelian randomization studies of unrelated individuals can be biased due to uncontrolled confounding from familial effects. Here we describe methods for within-family Mendelian randomization analyses and ...

    • Biological and Clinical Insights From Genetics of Insomnia Symptoms 

      Lane, Jacqueline M.; Jones, Samuel E.; Skogholt, Anne Heidi; Gabrielsen, Maiken Elvestad; Hveem, Kristian; Brumpton, Ben Michael; Zwart, John-Anker; Nielsen, Jonas Bille; Winswold, Bendik; Willer, Cristen J; Janszky, Imre; Johnsen, Marianne Bakke; Wood, Andrew R.; Strand, Linn B.; Bowden, Jack; Song, Yanwei; Patel, Krunal; Anderson, Simon G.; Beaumont, Robin N.; Bechtold, David A.; Cade, Brian E.; Kathiresan, Sekar; Little, Max A.; Loudon, Andrew S.; Purcell, Shaun; Richmond, Rebecca C.; Schormair, Barbara; Tyrrell, Jessica; Winkelmann, Juliane; Zhao, Cheng; Redline, Susan; Spiegelhalder, Kai; Kyle, Simon D.; Frayling, Timothy M.; Lawlor, Deborah A.; Rutter, Martin K.; Weedon, Michael N.; Saxena, Richa (Journal article; Peer reviewed, 2019)
      Insomnia is a common disorder linked with adverse long-term medical and psychiatric outcomes. The underlying pathophysiological processes and causal relationships of insomnia with disease are poorly understood. Here we ...

    • Body mass index and incidence of lung cancer in the HUNT study: using observational and Mendelian randomization approaches 

      Jiang, Lin; Sun, Yi-Qian; Brumpton, Ben Michael; Langhammer, Arnulf; Chen, Yue; Mai, Xiao-Mei (Peer reviewed; Journal article, 2022)
      Background Traditional observational studies have shown an inverse association between body mass index (BMI) and lung cancer risk. Mendelian randomization (MR) analysis using genetic variants as instruments for BMI may ...

    • Body mass index and risk of dying from a bloodstream infection: A Mendelian randomization study 

      Rogne, Tormod; Solligård, Erik; Burgess, Stephen; Brumpton, Ben Michael; Paulsen, Julie; Pescott, Hallie; Mohus, Randi Marie; Gustad, Lise Tuset; Mehl, Arne; Åsvold, Bjørn Olav; DeWan, Andrew; Damås, Jan Kristian (Journal article; Peer reviewed, 2020)

    • The causes and consequences of Alzheimer’s disease: phenome-wide evidence from Mendelian randomization 

      Korologou-Linden, Roxanna; Bhatta, Laxmi; Brumpton, Ben Michael; Howe, Laura D.; Millard, Louise A. C.; Kolaric, Katarina; Ben-Shlomo, Yoav; Williams, Dylan M.; Smith, George Davey; Anderson, Emma L.; Stergiakouli, Evie; Davies, Neil Martin (Peer reviewed; Journal article, 2022)
      Alzheimer’s disease (AD) has no proven causal and modifiable risk factors, or effective interventions. We report a phenome-wide association study (PheWAS) of genetic liability for AD in 334,968 participants of the UK Biobank ...

    • Chronic obstructive pulmonary disease (COPD): Influence of comorbidities on health status, morbidity and mortality in a 25 years follow-up populationbased study. The HUNT Study. 

      Vikjord, Sigrid Anna Aalberg (Doctoral theses at NTNU;2020:254, Doctoral thesis, 2020)

    • Cohort Profile Update: The HUNT Study, Norway 

      Åsvold, Bjørn Olav; Langhammer, Arnulf; Rehn, Tommy Aune; Kjelvik, Grete; Grøntvedt, Trond Viggo; Sørgjerd, Elin Pettersen; Fenstad, Jørn; Heggland, Jon; Holmen, Oddgeir; Stuifbergen, Maria C; Vikjord, Sigrid Anna Aalberg; Brumpton, Ben Michael; Skjellegrind, Håvard; Thingstad, Pernille; Sund, Erik; Selbæk, Geir; Mork, Paul Jarle; Rangul, Vegar; Hveem, Kristian; Næss, Marit; Krokstad, Steinar (Peer reviewed; Journal article, 2022)

    • COL11A1 is associated with developmental dysplasia of the hip and secondary osteoarthritis in the HUNT study 

      Jacobsen, Kaya Kvarme; Børte, Sigrid; Laborie, Lene Bjerke; Kristiansen, Hege; Schäfer, Annette; Gundersen, Trude; Zayats, Tetyana; Winsvold, Bendik Kristoffer Slagsvold; Karen, Rosendahl; Martinsen, Amy; Skogholt, Anne Heidi; Brumpton, Ben Michael; Willer, Cristen J; Fors, Egil Andreas; Kristoffersen, Espen Saxhaug; Heuch, Ingrid; Mundal, Ingunn Pernille; Zwart, John Anker Henrik; Nielsen, Jonas B.; Storheim, Kjersti; Hagen, Knut; Nilsen, Kristian Bernhard; Hveem, Kristian; Fritsche, Lars G; Thomas, Laurent Francois; Pedersen, Linda Margareth; Gabrielsen, Maiken Elvestad; Lie, Marie U.; Stensland, Synne; Zhou, Wei (Peer reviewed; Journal article, 2023)
      Objective: Developmental dysplasia of the hip (DDH) is a congenital condition affecting 2-3% of all infants. DDH increases the risk of osteoarthritis, is the cause of 30% of all total hip arthroplasties (THAs) in adults ...

    • Combined effects of five prothrombotic genotypes and cancer on the risk of a first venous thromboembolic event 

      Skille, Hanne; Paulsen, Benedikte; Hveem, Kristian; Gabrielsen, Maiken Elvestad; Brumpton, Ben Michael; Hindberg, Kristian; Gran, Olga Vikhammer; Rosendaal, Frits Richard; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Peer reviewed; Journal article, 2020)
      Background: The role of combined prothrombotic genotypes in cancer-related venous thromboembolism (VTE) is scarcely studied. We aimed to investigate the impact of a 5-single nucleotide polymorphism (SNP) score on the risk ...