• Aerobic exercise training rescues cardiac protein quality control and blunts endoplasmic reticulum stress in heart failure rats 

      Bozi, Luiz H.M.; Jannig, Paulo R; Rolim, Natale Pinheiro Lage; Voltarelli, Vanessa; Dourado, Paulo MM; Wisløff, Ulrik; Brum, Patricia C. (Peer reviewed; Journal article, 2016)
      Cardiac endoplasmic reticulum (ER) stress through accumulation of misfolded proteins plays a pivotal role in cardiovascular diseases. In an attempt to reestablish ER homoeostasis, the unfolded protein response (UPR) is ...
    • Differential regulation of cysteine oxidative post-translational modifications in high and low aerobic capacity 

      Souza, Rodrigo W. A.; Alves, Christiano R. R.; Medeiros, Alessandra; Rolim, Natale Pinheiro Lage; Silva, Gustavo Jose Justo; Moreira, Jose Bianco Nascimento; Alves, Marcia Netto Magalhaes; Wohlwend, Martin; Gebriel, Mohammed; Hagen, Lars; Sharma, Animesh; Koch, Lauren G.; Britton, Steven L.; Slupphaug, Geir; Wisløff, Ulrik; Brum, Patricia C. (Journal article; Peer reviewed, 2018)
      Given the association between high aerobic capacity and the prevention of metabolic diseases, elucidating the mechanisms by which high aerobic capacity regulates whole-body metabolic homeostasis is a major research challenge. ...
    • Exercise prevents impaired autophagy and proteostasis in a model of neurogenic myopathy 

      Campos, Juliane C; Baehr, Leslie M; Gomes, Katia M S; Bechara, Luiz R.G.; Voltarelli, Vanessa; Bozi, Luiz H.M.; Ribeiro, Marcio AC; Ferreira, Nikolas D; Moreira, Jose Bianco Nascimento; Brum, Patricia C.; Bodine, Sue C; Ferreira, Julio CB (Journal article; Peer reviewed, 2018)
      Increased proteolytic activity has been widely associated with skeletal muscle atrophy. However, elevated proteolysis is also critical for the maintenance of cellular homeostasis by disposing cytotoxic proteins and ...
    • Integrative effect of carvedilol and aerobic exercise training therapies on improving cardiac contractility and remodeling in heart failure mice 

      Vanzelli, Andréa S.; Medeiros, Alessandra; Rolim, Natale Pinheiro Lage; Bartholomeu, Jan B.; Cunha, Telma F.; Bechara, Luiz G.; Gomes, Enéas R.M.; Mattos, Katt C.; Sirvente, Raquel; Salemi, Vera; Mady, Charles; Negrao, Carlos E.; Guatimosim, Silvia; Brum, Patricia C. (Journal article; Peer reviewed, 2013)
      The use of β-blockers is mandatory for counteracting heart failure (HF)-induced chronic sympathetic hyperactivity, cardiac dysfunction and remodeling. Importantly, aerobic exercise training, an efficient nonpharmacological ...