Browsing NTNU Open by Author "Brodtkorb, Eylert"

Now showing items 1-20 of 32

    • ADCK3 mutations with epilepsy, stroke-like episodes and ataxia: a POLG mimic? 

      Hikmat, Omar; Tzoulis, Charalampos; Knappskog, Per; Johansson, Stefan; Boman, Helge; Sztromwasser, Pawel Szymon; Lien, Espen; Brodtkorb, Eylert; Ghezzi, Daniele; Bindoff, Laurence (Journal article; Peer reviewed, 2016)
      Background and purpose Defects of coenzyme Q10 (CoQ10) metabolism cause a variety of disorders ranging from isolated myopathy to multisystem involvement. ADCK3 is one of several genes associated with CoQ10 deficiency ...

    • Alcohol and epileptic seizures 

      Strindler, Tåle Trond Ivan; Myklebust, Harald (Master thesis, 2017)
      Purpose: The aim of this study was to investigate the relationship between alcohol use and seizures in acutely hospitalized patients, both isolated seizures as well as in diagnosed epilepsy. We wished to study the extent ...

    • Bidirectionality of antiseizure and antipsychotic treatment: A population-based study 

      Revdal, Eline; Morken, Gunnar; Bakken, Inger Johanne; Bråthen, Geir; Landmark, Cecilie Johannessen; Brodtkorb, Eylert (Peer reviewed; Journal article, 2022)
      Purpose To study the prevalence and directionality of comorbid epilepsy and psychosis in Norway. Methods The Norwegian Prescription Database (NorPD) provided individual-based information on all antiseizure medications ...

    • CAUSAL FACTORS AND PROGNOSIS OF STATUS EPILEPTICUS 

      Hoggen, Ingvild; Lie, Ingrid Anne (Master thesis, 2013)
      Purpose: To evaluate the duration, treatment and prognosis of status epilepticus (SE) in relation to cause. Of particular interest was to examine how nonadherence to prophylactic medication contributed to SE in patients ...

    • Characteristics of Focal Epilepsies among Participants in HUNT 2 and 3 

      Aakvåg, Marte Liang; Salcedo-Hokstad, Patricia (Master thesis, 2020)
      Bakgrunn: Det innsamlede datamaterialet fra helseundersøkelsene i Nord-Trøndelag (HUNT) gir en enestående database med helseopplysninger, kliniske målinger og biologisk materiale tilgjengelig for forskning. Som en del av ...

    • Characteristics of Focal Epilepsies among Participants in HUNT 2 and 3 

      Aakvåg, Marte Liang; Salcedo-Hokstad, Patricia (Master thesis, 2020)
      Bakgrunn: Det innsamlede datamaterialet fra helseundersøkelsene i Nord-Trøndelag (HUNT) gir en enestående database med helseopplysninger, kliniske målinger og biologisk materiale tilgjengelig for forskning. Som en del av ...

    • Clinical experience combined with therapeutic drug monitoring of lacosamide 

      Svendsen, Torleiv; Brodtkorb, Eylert; Baftiu, Arton; Lossius, Morten; Nakken, Karl Otto; Johannessen, Svein Ivar; Landmark, Cecilie Johannessen (Peer reviewed; Journal article, 2019)
      Objective Lacosamide (LCM) is an antiepileptic drug (AED) with insufficient clinical experience in patients with intellectual disability (ID). They often have more severe epilepsy with comorbidities. The objective was to ...

    • Efficacy, tolerability and pharmacokinetic variability of brivaracetam in adults with difficult-to-treat epilepsy 

      Svendsen, Torleiv; Brodtkorb, Eylert; Linge, Hanna Lande; Burns, Margrete Larsen; Johannessen, Svein Ivar; Nakken, Karl Otto; Lossius, Morten Ingvar; Landmark, Cecilie Johannessen (Peer reviewed; Journal article, 2022)
      Purpose: Brivaracetam (BRV) is one of our latest antiseizure medications (ASMs). It is an analogue of levetiracetam with limited real-life experience. The purpose of this study was to evaluate clinical experience with BRV ...

    • Epilepsy and other seizure disorders in acute psychiatric inpatients 

      Nakken, Erlend Iversen; Grinde, Frithjof; Vaaler, Arne; Drange, Ole Kristian; Brodtkorb, Eylert; Sæther, Sverre Georg (Peer reviewed; Journal article, 2021)
      Background: It is well known that patients with epilepsy have a high rate of psychiatric comorbidity. However, studies exploring epilepsy in psychiatric cohorts are scarce. The aim of this study was to examine the prevalence ...

    • Epilepsy as a Network Disorder From Zebrafish to Humans 

      Myren-Svelstad, Sverre (Doctoral theses at NTNU;2022:217, Doctoral thesis, 2022)

    • Epilepsy in classic Rett syndrome: Course and characteristics in adult age 

      Henriksen, Mari Wold; Breck, Hilde; von Tetzchner, Stephen; Paus, Benedicte; Skjeldal, Ola; Brodtkorb, Eylert (Journal article; Peer reviewed, 2018)
      Purpose Rett syndrome (RTT) is a neurodevelopmental disorder that almost exclusively affects females. Epilepsy is a major clinical feature, but its long-term course in RTT has not been sufficiently explored. This study ...

    • Epilepsy in the county of Nord-Trøndelag - Diagnostic Difficulties and Focus on Generalized Epilepsy 

      Kolstad, Patrick Bjørn; Sandtrøen, Kristoffer (Master thesis, 2020)
      Bakgrunn: Folkehelseundersøkelsen i Nord-Trøndelag (HUNT) er en av de største epidemiologiske studiene som er blitt gjennomført. Studien gir en unik database med helseopplysninger, kliniske målinger og biologisk materiale. ...

    • Epilepsy patients with and without perceived benefit from vagus nerve stimulation: A long-term observational single center study 

      Brodtkorb, Eylert; Samsonsen, Christian; Jørgensen, Jan V.; Helde, Grethe (Peer reviewed; Journal article, 2019)
      Purpose: Vagus nerve stimulaton (VNS) has been used for adjunctive treatment of drug-resistant epilepsy for more than 25 years. The true efficacy has been debated, as blinded randomized controlled trials are unavailable. ...

    • Epileptological aspects of juvenile neuronal ceroid lipofuscinosis (CLN3 disease) through the lifespan 

      Arntsen, Vibeke; Strandheim, John; Helland, Ingrid B; Sand, Trond; Brodtkorb, Eylert (Journal article; Peer reviewed, 2019)
      Purpose Juvenile neuronal ceroid lipofuscinosis (CLN3 disease) is the most common neurodegenerative disorder in childhood with survival until young adult age. Visual loss is followed by epilepsy, cognitive, neuropsychiatric, ...

    • Experiential seizures related to the hippocampal-parahippocampal spatial representation system 

      Revdal, Eline; Arntsen, Vibeke; Doan, Thanh Pierre; Kvello-Alme, Marte; Kvistad, Kjell Arne; Bråthen, Geir; Brodtkorb, Eylert (Peer reviewed; Journal article, 2020)
      Ictal visual hallucinations may have occipital as well as temporal lobe origin. We report a patient with clustering of focal aware seizures with visual hallucinations. Ictal EEG findings and seizure semiology with alternating ...

    • Global Metabolomics Discovers Two Novel Biomarkers in Pyridoxine-Dependent Epilepsy Caused by ALDH7A1 Deficiency 

      Böhm, Hans-Otto; Yazdani, Mazyar; Mørk Sandås, Elise; Østeby Vassli, Anja; Kristensen, Erle; Rootwelt, Helge; Skogvold, Hanne Bendiksen; Brodtkorb, Eylert; Elgstøen, Katja B. Prestø (Peer reviewed; Journal article, 2022)
      Pyridoxine-dependent epilepsy (PDE) is a rare autosomal recessive developmental and epileptic encephalopathy caused by pathogenic variants in the ALDH7A1 gene (PDE-ALDH7A1), which mainly has its onset in neonates and ...

    • The impact of gender, puberty, and pregnancy in patients with POLG disease 

      Hikmat, Omar; Naess, Karin; Engvall, Martin; Klingenberg, Claus; Rasmussen, Magnhild; Tallaksen, Chantal; Samsonsen, Christian; Brodtkorb, Eylert; Ostergaard, Elsebet; de Coo, Rene; Pias-Peleteiro, Leticia; Isohanni, Pirjo; Uusimaa, Johanna; Darin, Niklas; Rahman, Shamima; Bindoff, Laurence (Peer reviewed; Journal article, 2020)
      Objective To study the impact of gender, puberty, and pregnancy on the expression of POLG disease, one of the most common mitochondrial diseases known. Methods Clinical, laboratory, and genetic data were collected ...

    • The impact of gender, puberty, and pregnancy in patients with POLG disease 

      Hikmat, Omar; Naess, Karin; Engvall, Martin; Klingenberg, Claus; Rasmussen, Magnhild; Tallaksen, Chantal; Samsonsen, Christian; Brodtkorb, Eylert; Ostergaard, Elsebet; de Coo, Rene; Pias-Peleteiro, Leticia; Isohanni, Pirjo; Uusimaa, Johanna; Darin, Niklas; Rahman, Shamima; Bindoff, Laurence (Peer reviewed; Journal article, 2020)
      Objective To study the impact of gender, puberty, and pregnancy on the expression of POLG disease, one of the most common mitochondrial diseases known. Methods Clinical, laboratory, and genetic data were collected ...

    • Mechanisms underlying aggressive behavior induced by antiepileptic drugs: Focus on topiramate, levetiracetam, and perampanel 

      Hansen, Cerine Corin; Ljung, Hanna; Brodtkorb, Eylert; Reimers, Arne (Journal article; Peer reviewed, 2018)
      Antiepileptic drugs (AEDs) are effective against seizures, but their use is often limited by adverse effects, among them psychiatric and behavioral ones including aggressive behavior (AB). Knowledge of the incidence, risk ...

    • Mental health and health related quality of life in mitochondrial POLG disease 

      Hikmat, Omar; Vederhus, Bente Johanne; Benestad, Merete Roineland; Engeset, Ida Malen E.; Klingenberg, Claus; Rasmussen, Magnhild; Tallaksen, Chantal; Brodtkorb, Eylert; Elgen, Irene Bircow; Bindoff, Laurence (Peer reviewed; Journal article, 2020)
      We aimed to assess the impact of POLG disease on mental health and quality of life in 15 patients using the Symptom Checklist-90-R (SCL-90-R) and Short-Form 36 Health Survey (RAND-36). We found increased scores in all nine ...