• ADCK3 mutations with epilepsy, stroke-like episodes and ataxia: a POLG mimic? 

      Hikmat, Omar; Tzoulis, Charalampos; Knappskog, Per; Johansson, Stefan; Boman, Helge; Sztromwasser, Pawel Szymon; Lien, Espen; Brodtkorb, Eylert; Ghezzi, Daniele; Bindoff, Laurence (Journal article; Peer reviewed, 2016)
      Background and purpose Defects of coenzyme Q10 (CoQ10) metabolism cause a variety of disorders ranging from isolated myopathy to multisystem involvement. ADCK3 is one of several genes associated with CoQ10 deficiency ...
    • Alcohol and epileptic seizures 

      Strindler, Tåle Trond Ivan; Myklebust, Harald (Master thesis, 2017)
      Purpose: The aim of this study was to investigate the relationship between alcohol use and seizures in acutely hospitalized patients, both isolated seizures as well as in diagnosed epilepsy. We wished to study the extent ...
    • CAUSAL FACTORS AND PROGNOSIS OF STATUS EPILEPTICUS 

      Hoggen, Ingvild; Lie, Ingrid Anne (Master thesis, 2013)
      Purpose: To evaluate the duration, treatment and prognosis of status epilepticus (SE) in relation to cause. Of particular interest was to examine how nonadherence to prophylactic medication contributed to SE in patients ...
    • Clinical experience combined with therapeutic drug monitoring of lacosamide 

      Svendsen, Torleiv; Brodtkorb, Eylert; Baftiu, Arton; Lossius, Morten; Nakken, Karl Otto; Johannessen, Svein Ivar; Landmark, Cecilie Johannessen (Peer reviewed; Journal article, 2019)
      Objective Lacosamide (LCM) is an antiepileptic drug (AED) with insufficient clinical experience in patients with intellectual disability (ID). They often have more severe epilepsy with comorbidities. The objective was to ...
    • Epilepsy in classic Rett syndrome: Course and characteristics in adult age 

      Henriksen, Mari Wold; Breck, Hilde; von Tetzchner, Stephen; Paus, Benedicte; Skjeldal, Ola; Brodtkorb, Eylert (Journal article; Peer reviewed, 2018)
      Purpose Rett syndrome (RTT) is a neurodevelopmental disorder that almost exclusively affects females. Epilepsy is a major clinical feature, but its long-term course in RTT has not been sufficiently explored. This study ...
    • Epileptological aspects of juvenile neuronal ceroid lipofuscinosis (CLN3 disease) through the lifespan 

      Arntsen, Vibeke; Strandheim, John; Helland, Ingrid B; Sand, Trond; Brodtkorb, Eylert (Journal article; Peer reviewed, 2019)
      Purpose Juvenile neuronal ceroid lipofuscinosis (CLN3 disease) is the most common neurodegenerative disorder in childhood with survival until young adult age. Visual loss is followed by epilepsy, cognitive, neuropsychiatric, ...
    • The impact of gender, puberty, and pregnancy in patients with POLG disease 

      Hikmat, Omar; Naess, Karin; Engvall, Martin; Klingenberg, Claus; Rasmussen, Magnhild; Tallaksen, Chantal; Samsonsen, Christian; Brodtkorb, Eylert; Ostergaard, Elsebet; de Coo, Rene; Pias-Peleteiro, Leticia; Isohanni, Pirjo; Uusimaa, Johanna; Darin, Niklas; Rahman, Shamima; Bindoff, Laurence (Peer reviewed; Journal article, 2020)
      Objective To study the impact of gender, puberty, and pregnancy on the expression of POLG disease, one of the most common mitochondrial diseases known. Methods Clinical, laboratory, and genetic data were collected ...
    • Mechanisms underlying aggressive behavior induced by antiepileptic drugs: Focus on topiramate, levetiracetam, and perampanel 

      Hansen, Cerine Corin; Ljung, Hanna; Brodtkorb, Eylert; Reimers, Arne (Journal article; Peer reviewed, 2018)
      Antiepileptic drugs (AEDs) are effective against seizures, but their use is often limited by adverse effects, among them psychiatric and behavioral ones including aggressive behavior (AB). Knowledge of the incidence, risk ...
    • Mental health and health related quality of life in mitochondrial POLG disease 

      Hikmat, Omar; Vederhus, Bente Johanne; Benestad, Merete Roineland; Engeset, Ida Malen E.; Klingenberg, Claus; Rasmussen, Magnhild; Tallaksen, Chantal; Brodtkorb, Eylert; Elgen, Irene Bircow; Bindoff, Laurence (Peer reviewed; Journal article, 2020)
      We aimed to assess the impact of POLG disease on mental health and quality of life in 15 patients using the Symptom Checklist-90-R (SCL-90-R) and Short-Form 36 Health Survey (RAND-36). We found increased scores in all nine ...
    • Reference ranges for antiepileptic drugs revisited: a practical approach to establish national guidelines 

      Reimers, Arne; Berg, Jon Andsnes; Burns, Margrete Larsen; Brodtkorb, Eylert; Johannessen, Svein Ivar; Landmark, Cecilie Johannessen (Journal article; Peer reviewed, 2018)
      Background and objective: Laboratories sometimes use different reference ranges for the same antiepileptic drug (AED), particularly for new and poorly investigated drugs. This may contribute to misunderstandings, concerns ...
    • Remarkable effect of transdermal nicotine in children with CHRNA4- related autosomal dominant sleep-related hypermotor epilepsy 

      Lossius, Kristine; de Saint Martin, Anne; Myren-Svelstad, Sverre; Bjørnvold, Marit; Minken, Guro; Seegmuller, Caroline; Valenti Hirsch, Maria Paola; Chelly, Jamel; Steinlein, Ortrud; Picard, Fabienne; Brodtkorb, Eylert (Peer reviewed; Journal article, 2020)
      Objective Autosomal dominant sleep-related hypermotor epilepsy (ADSHE) is characterized by hypermotor seizures and may be caused by gain-of-function mutations affecting the nicotinic acetylcholine receptor (nAChR). Benefit ...
    • Seizure Precipitants 

      Samsonsen, Christian (Doctoral theses at NTNU;2017:214, Doctoral thesis, 2017)
      In the comprehensive management of epilepsy, both preventive pharmacological treatment and awareness of possible seizure precipitating factors are important. The true cause of seizure generation is often hard to disentangle, ...
    • Simplifying the clinical classification of polymerase gamma (POLG) disease based on age of onset; studies using a cohort of 155 cases 

      Hikmat, Omar; Naess, Karin; Engvall, Martin; Klingenberg, Claus; Rasmussen, Magnhild; Tallaksen, Chantal; Brodtkorb, Eylert; Østergaard, Elsebet; de Coo, Irenaeus F.M.; Pias-Peleteiro, Leticia; Isohanni, Pirjo; Uusimaa, Johanna; Darin, Niklas; Rahman, Shamima; Bindoff, Laurence (Peer reviewed; Journal article, 2020)
      Background Variants in POLG are one of the most common causes of inherited mitochondrial disease. Phenotypic classification of POLG disease has evolved haphazardly making it complicated and difficult to implement in ...
    • The Impact of Pharmacokinetic Interactions with Eslicarbazepine Acetate Versus Oxcarbazepine and Carbamazepine in Clinical Practice 

      Landmark, Cecilie Johannessen; Svendsen, Torleiv; Dinarevic, Jasmin; Kufaas, Ruben F.; Reimers, Arne; Brodtkorb, Eylert; Baftiu, Arton; Burns, Margrete Larsen; Johannessen, Svein Ivar (Journal article; Peer reviewed, 2016)
      Background: Eslicarbazepine acetate (ESL) is a new anti-epileptic drug (AED) chemically related to oxcarbazepine (OXC) and carbamazepine (CBZ) and is increasingly used in clinical practice. The purpose of the study was to ...
    • Therapeutic Drug Monitoring of Lacosamide in Norway: Focus on Pharmacokinetic Variability, Efficacy and Tolerability. 

      Svendsen, Torleiv; Brodtkorb, Eylert; Baftiu, Arton; Burns, Margrete Larsen; Johannessen, Svein Ivar; Landmark, Cecilie Johannessen (Journal article; Peer reviewed, 2017)
      Lacosamide (LCM) is a new antiepileptic drug (AED). Experience from therapeutic drug monitoring (TDM) in clinical practice is limited. The purpose of this study is to evaluate the pharmacokinetic variability of LCM in ...