• Aerobic exercise training rescues cardiac protein quality control and blunts endoplasmic reticulum stress in heart failure rats 

      Bozi, Luiz H.M.; Jannig, Paulo R; Rolim, Natale Pinheiro Lage; Voltarelli, Vanessa; Dourado, Paulo MM; Wisløff, Ulrik; Brum, Patricia C. (Peer reviewed; Journal article, 2016)
      Cardiac endoplasmic reticulum (ER) stress through accumulation of misfolded proteins plays a pivotal role in cardiovascular diseases. In an attempt to reestablish ER homoeostasis, the unfolded protein response (UPR) is ...
    • Autophagy signaling in skeletal muscle of infarcted rats 

      Jannig, Paulo R.; Moreira, Jose Bianco Nascimento; Bechara, Luiz R.G.; Bozi, Luiz H.M.; Bacurau, Aline V.; Monteiro, Alex W.A.; Dourado, Paulo M.; Wisløff, Ulrik; Brum, Patricia Chakur (Journal article; Peer reviewed, 2014)
      Background: Heart failure (HF)-induced skeletal muscle atrophy is often associated to exercise intolerance and poor prognosis. Better understanding of the molecular mechanisms underlying HF-induced muscle atrophy may ...
    • Exercise prevents impaired autophagy and proteostasis in a model of neurogenic myopathy 

      Campos, Juliane C; Baehr, Leslie M; Gomes, Katia M S; Bechara, Luiz R.G.; Voltarelli, Vanessa; Bozi, Luiz H.M.; Ribeiro, Marcio AC; Ferreira, Nikolas D; Moreira, Jose Bianco Nascimento; Brum, Patricia C.; Bodine, Sue C; Ferreira, Julio CB (Journal article; Peer reviewed, 2018)
      Increased proteolytic activity has been widely associated with skeletal muscle atrophy. However, elevated proteolysis is also critical for the maintenance of cellular homeostasis by disposing cytotoxic proteins and ...