Browsing NTNU Open by Author "Blankvoort, Stefan"
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Catering new neurons to environmental needs: Activity of granule cells regulates neurogenesis in the dentate gyrus
Blankvoort, Stefan (Doctoral thesis at NTNU;2016:32, Doctoral thesis, 2016)The mammalian adult dentate gyrus generates new neurons. In a process called adult neurogenesis neural stem cells give rise to new neurons that mature and integrate into the existing neural network. By their addition and ... -
Enhancer-Driven Gene Expression (EDGE) Enables the Generation of Viral Vectors Specific to Neuronal Subtypes
Nair Raveendran, Rajeevkumar; Blankvoort, Stefan; Lagartos, Maria Jose; Kentros, Clifford (Journal article; Peer reviewed, 2020)Although a variety of remarkable molecular tools for studying neural circuits have recently beendeveloped, the ability to deploy them in particular neuronal subtypes is limited by the fact that nativepromoters are almost ... -
Exploring connectivity in layer III of the mouse medial entorhinal cortex using viral tracers and novel transgenic tools
Flatset, Marcus Sandbukt (Master thesis, 2019)The entorhinal cortex is the main gateway between the hippocampal formation and the neocortex. The entorhinal cortex mainly projects to the hippocampal formation via layers II and III. While the various functions of ... -
Inhibitory Connectivity Dominates the Fan Cell Network in Layer II of Lateral Entorhinal Cortex
Nilssen, Eirik Stamland; Jacobsen, Bente; Fjeld, Gunhild; Nair, Rajeevkumar Raveendran; Blankvoort, Stefan; Kentros, Clifford; Witter, Menno (Journal article; Peer reviewed, 2018)Fan cells in layer II of the lateral entorhinal cortex (LEC) form a main component of the projection to the dentate gyrus, CA3 and CA2 of the hippocampal formation. This projection has a counterpart originating from stellate ... -
Local projections of layer Vb-to-Va are more prominent in lateral than in medial entorhinal cortex
Ohara, Shinya; Blankvoort, Stefan; Nair Raveendran, Rajeevkumar; Nigro, Maximiliano Jose; Nilssen, Eirik Stamland; Kentros, Clifford; Witter, Menno (Peer reviewed; Journal article, 2021)The entorhinal cortex, in particular neurons in layer V, allegedly mediate transfer of information from the hippocampus to the neocortex, underlying long-term memory. Recently, this circuit has been shown to comprise a ... -
Multiplexing viral approaches to the study of the neuronal circuits
Chadney, Oscar Michael Thornton; Blankvoort, Stefan; Grimstvedt, Joachim Schweder; Utz, Annika; Kentros, Clifford (Peer reviewed; Journal article, 2021)Neural circuits are composed of multitudes of elaborately interconnected cell types. Understanding neural circuit function requires not only cell-specific knowledge of connectivity, but the ability to record and manipulate ... -
A neurogenic microenvironment defined by excitatory-inhibitory neuronal circuits in adult dentate gyrus
Blankvoort, Stefan; Uemura, Masato; Tok, Sean Shui Liang; Yuan, Li; lit, kwok; tashiro, ayumu (Peer reviewed; Journal article, 2021)Adult neurogenesis in the dentate gyrus plays a role in adaptive brain functions such as memory formation. Adding new neurons to a specific locus of a neural circuit with functional needs is an efficient way to achieve ... -
Next generation recombinant viral vectors: an investigation of enhancer driven transgene expression in the subthalamic nucleus after viral vector mediated transfection.
Nordeidet, Ada Nilsen (Master thesis, 2020)Den subthalamiske kjernen (STN) inngår i en signalkrets i de basale gangliene (BG), og denne kretsen er dysfunksjonell hos pasienter med Parkinsons sykdom (PD), noe som resulterer i bevegelsesforstyrrelser. Dyp hjernestimulering ... -
Single Cell Transcriptomic and Chromatin Profiles Suggest Layer Vb Is the Only Layer With Shared Excitatory Cell Types in the Medial and Lateral Entorhinal Cortex
Blankvoort, Stefan; Olsen, Lene Christin; Kentros, Clifford (Peer reviewed; Journal article, 2022)All brain functionality arises from the activity in neural circuits in different anatomical regions. These regions contain different circuits comprising unique cell types. An integral part to understanding neural circuits ... -
VIRUS MEDIATED EXPRESSION OF DOUBLE FLOXED GENESIN NEURONS OF THE DENTATE GYRUS: The exploration of a new method to ablate adult born neurons
Blankvoort, Stefan (Master thesis, 2010)Adult neurogenesis is a process occurring in the mammalian dentate gyrus (a region in the hippocampus). Various lines of evidence show that this process is involved in learning and memory. The exact role of the adult born ...