Blar i NTNU Open på forfatter "Bjorkli, Christiana"
-
Bridging the gap between fluid biomarkers for Alzheimer’s disease, model systems, and patients
Bjorkli, Christiana; Sandvig, Axel; Sandvig, Ioanna (Peer reviewed; Journal article, 2020)Alzheimer’s disease (AD) is a debilitating neurodegenerative disease characterized by the accumulation of two proteins in fibrillar form: amyloid-β (Aβ) and tau. Despite decades of intensive research, we cannot yet pinpoint ... -
Combined targeting of pathways regulating synaptic formation and autophagy attenuates Alzheimer’s disease pathology in mice
Bjorkli, Christiana; Hemler, Mary Elizabeth; Julian, Joshua B; Sandvig, Axel; Sandvig, Ioanna (Peer reviewed; Journal article, 2022)All drug trials completed to date have fallen short of meeting the clinical endpoint of significantly slowing cognitive decline in Alzheimer’s disease (AD) patients. In this study, we repurposed two FDA-approved drugs, ... -
In Vivo Microdialysis in Mice Captures Changes in Alzheimer´s Disease Cerebrospinal Fluid Biomarkers Consistent with Developing Pathology
Bjorkli, Christiana; Louet, Claire; Flo, Trude Helen; Hemler, Mary Elizabeth; Sandvig, Axel; Sandvig, Ioanna (Peer reviewed; Journal article, 2021)Background: Preclinical models of Alzheimer’s disease (AD) can provide valuable insights into the onset and progression of the disease, such as changes in concentrations of amyloid-β (Aβ) and tau in cerebrospinal fluid ... -
Lowering levels of reelin in entorhinal cortex layer II-neurons results in lowered levels of intracellular amyloid-β
Kobro-Flatmoen, Asgeir; Battistin, Claudia; Raveendran Nair, Rajeevkumar; Bjorkli, Christiana; Skender, Belma; Kentros, Clifford George; Gouras, Gunnar; Witter, Menno Peter (Peer reviewed; Journal article, 2023)Projection neurons in the anteriolateral part of entorhinal cortex layer II are the predominant cortical site for hyper-phosphorylation of tau and formation of neurofibrillary tangles in prodromal Alzheimer’s disease. A ...