• Improved drug delivery to brain metastases by peptide-mediated permeabilization of the blood-brain barrier 

      Aasen, Synnøve Nymark; Espedal, Heidi; Holte, Christopher Florian; Keunen, Olivier; Karlsen, Tine Veronica; Tenstad, Olav; Maherally, Zaynah; Miletic, Hrvoje; Hoang, Tuyen; Eikeland, Anne Vaag; Baghirov, Habib; Olberg, Dag Erlend; Pilkington, Geoffrey John; Sarkar, Gobinda; Jenkins, Robert B.; Sundstrøm, Terje; Bjerkvig, Rolf; Thorsen, Frits (Peer reviewed; Journal article, 2019)
      Patients with melanoma have a high risk of developing brain metastasis, which is associated with a dismal prognosis. During early stages of metastasis development, the blood–brain barrier (BBB) is likely intact, which ...
    • Therapeutic Effect of Cabazitaxel and Blood-Brain Barrier opening in a Patient-Derived Glioblastoma Model 

      Sulheim, Einar; Mørch, Ýrr Asbjørg; Snipstad, Sofie; Borgos, Sven Even F.; Miletic, Hrvoje; Bjerkvig, Rolf; Davies, Catharina de Lange; Åslund, Andreas (Journal article, 2019)
      Treatment of glioblastoma and other diseases in the brain is especially challenging due to the blood-brain barrier, which effectively protects the brain parenchyma. In this study we show for the first time that cabazitaxel, ...