• A Novel Truncated Form of Nephronectin Is Present in Small Extracellular Vesicles Isolated from 66cl4 Cells 

      Toraskar, Jimita Prashant; Norvoll Magnussen, Synnøve; Hagen, Lars; Sharma, Animesh; Hoang, Linh; Bjørkøy, Geir; Svineng, Gunbjørg; Steigedal, Tonje S. (Journal article; Peer reviewed, 2019)
      Extracellular vesicles are emerging as biomarkers in breast cancer. Our recent report suggested that an intracellular granular staining pattern of the extracellular matrix protein nephronectin (NPNT) in breast tumor sections ...
    • Analysis of interaction of murine 66cl4 and 67NR breast carcinomas with tumor-associated macrophages 

      Wolowczyk, Camilla Izabel (Master thesis, 2016)
      Breast cancer is the most common cancer among women in the world, and death is usually caused by metastasis. A tumor is a heterogeneous mass of different cells, and the tumor microenvironment is complex with extensive ...
    • Autocrine activin A signalling in ovarian cancer cells regulates secretion of interleukin 6, autophagy, and cachexia 

      Pettersen, Kristine; Andersen, Sonja Benedikte; van der Veen, Anna; Nonstad, Unni; Hatakeyema, Shinji; Lambert, Christian; Lach-Trifilieff, Estelle; Moestue, Siver Andreas; Kim, Jana; Grønberg, Bjørn Henning; Schilb, Alain; Jacobi, Carsten; Bjørkøy, Geir (Journal article; Peer reviewed, 2019)
      Background The majority of patients with advanced cancer develop cachexia, a weight loss syndrome that severely reduces quality of life and limits survival. Our understanding of the underlying mechanisms that cause the ...
    • Autophagy as a Survival Mechanism or a Cause of Disease 

      Pettersen, Kristine (Doctoral thesis at NTNU;2016:52, Doctoral thesis, 2016)
      Proper turnover of cellular components is crucial for all cells. If damaged or excessive content in the cell is not removed at a sufficient pace, normal cell functions may be compromised. The same may occur if the ...
    • Bone morphogenetic protein 4 and Gremlin-1 communication between mouse breast cancer cells and fibroblasts 

      Appiah, Christiana Opokuaah (Master thesis, 2016)
      Breast cancer (BC) metastasis is the leading cause of death in breast cancer patients. Interactions between breast cancer tumors and stromal cells allow the microenvironment surrounding the tumor to co-evolve into an ...
    • Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling 

      Pettersen, Kristine; Andersen, Sonja Benedikte; Degen, simone; Tadini, Valentina; Grosjean, Joel; Hatakeyama, Shinji; Tesfahun, Almaz Nigatu; Moestue, Siver Andreas; Kim, Jana; Nonstad, Unni; Romundstad, Pål Richard; Skorpen, Frank; Sørhaug, Sveinung; Amundsen, Tore; Grønberg, Bjørn Henning; Strasser, Florian; Stephens, Nathan; Hoem, Dag; Molven, Anders; Kaasa, Stein; Fearon, Kenneth; Jacobi, Carsten; Bjørkøy, Geir (Journal article; Peer reviewed, 2017)
      The majority of cancer patients with advanced disease experience weight loss, including loss of lean body mass. Severe weight loss is characteristic for cancer cachexia, a condition that significantly impairs functional ...
    • Characterization of birinapant-induced cell death in human monocytes and macrophage subtypes 

      Klaharn, Merisa (Master thesis, 2019)
      Macrophages play various roles in the body depending on the environment they reside due to their diversity and plasticity. Distinct functional phenotypes operate specific tasks, ranging from inflammation and host defense ...
    • Depletion of the human N-terminal acetyltransferase hNaa30 disrupts Golgi integrity and ARFRP1 localization 

      Starheim, Kristian K.; Kalvik, Thomas Vikestad; Bjørkøy, Geir; Arnesen, Thomas (Journal article; Peer reviewed, 2017)
      The organization of the Golgi apparatus (GA) is tightly regulated. Golgi stack scattering is observed in cellular processes such as apoptosis and mitosis, and has also been associated with disruption of cellular lipid ...
    • Developing quantitative imaging of Akt activation in tissue sections 

      Dam, Cornelia Gerarda (Master thesis, 2012)
      The PI3K/mTOR pathway regulates fundamental cellular processes such as proliferation, growth, metabolism and autophagy. PI3K signalling is often constitutively activated in cancer cells and tumours. Chemical inhibitors ...
    • DHA-induced stress response in human colon cancer cells - Focus on oxidative stress and autophagy 

      Pettersen, Kristine; Monsen, Vivi Anita Talstad; Pettersen, Caroline Hild; Overland, Hilde Bremseth; Pettersen, Grete Klippenvåg; Samdal, Helle; Tesfahun, Almaz Nigatu; Lundemo, Anne Gøril; Bjørkøy, Geir; Schønberg, Svanhild Margrethe Arentz (Journal article; Peer reviewed, 2016)
      Polyunsaturated fatty acids (PUFAs) are important constituents of the diet and health benefits of omega-3/n−3 PUFAs, especially eicosapentaenoic acid (EPA, 20:5 n−3) and docosahexaenoic acid (DHA, 22:6 n−3) have been well ...
    • DHA-induced stress response in human colon cancer cells - Focus on oxidative stress and autophagy 

      Pettersen, Kristine; Monsen, Vivi Anita Talstad; Pettersen, Caroline Hild; Overland, Hilde Bremseth; Pettersen, Grete Klippenvåg; Samdal, Helle; Tesfahun, Almaz Nigatu; Lundemo, Anne Gøril; Bjørkøy, Geir; Schønberg, Svanhild Margrethe Arentz (Journal article; Peer reviewed, 2016)
    • Gastrin activates autophagy and increases migration and survival of gastric adenocarcinoma cells 

      Rao, Shalini; Solum, Guri; Niederdorfer, Barbara; Nørsett, Kristin; Bjørkøy, Geir; Thommesen, Liv (Journal article; Peer reviewed, 2017)
      Background: The peptide hormone gastrin exerts a growth-promoting effect in both normal and malignant gastrointestinal tissue. Gastrin mediates its effect via the cholecystokinin 2 receptor (CCKBR/CCK2R). Although a ...
    • GREM1 is associated with metastasis and predicts poor prognosis in ER-negative breast cancer patients 

      Neckmann, Ulrike; Wolowczyk, Camilla; Hall, Martina; Almaas, Eivind; Ren, Jiang; Zhao, Sen; Johannessen, Bjarne; Skotheim, Rolf I.; Bjørkøy, Geir; Dijke, Peter Ten; Holien, Toril (Journal article; Peer reviewed, 2019)
      Background In breast cancer, activation of bone morphogenetic protein (BMP) signaling and elevated levels of BMP-antagonists have been linked to tumor progression and metastasis. However, the simultaneous upregulation of ...
    • Heterogeneity within the 66cl4 cell line from the 4T1 model of metastatic breast cancer 

      Tran, Tuong Vy Thi (Master thesis, 2018)
      Breast cancer is one of the most common form of cancer among women globally and metastasis is the primary cause of death in breast cancer patients. In the past decades it has been increasingly known that tumors are ...
    • Intracellular glutathione determines bortezomib cytotoxicity in multiple myeloma cells 

      Starheim, Kristian Kobbenes; Holien, Toril; Misund, Kristine; Johansson, Ida; Baranowska, Katarzyna Anna; Sponaas, Anne Marit; Hella, Hanne; Buene, Glenn; Waage, Anders; Sundan, Anders; Bjørkøy, Geir (Journal article; Peer reviewed, 2016)
      Multiple myeloma (myeloma in short) is an incurable cancer of antibody-producing plasma cells that comprise 13% of all hematological malignancies. The proteasome inhibitor bortezomib has improved treatment significantly, ...
    • KRAS-mutasjonsstatus i diagnostikk og behandling av kreft 

      Nordraak, Anne Ohren; Skog, Marte (Bachelor thesis, 2020)
      Kreft er en samlebetegnelse på en stor gruppe sykdommer, som har til felles at de starter med ukontrollert cellevekst. Kreftceller og tumorvev har helt spesielle egenskaper sammenlignet med normalt vev. Dette er seks ...
    • Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration 

      Felszeghy, Szabolcs; Viiri, Johanna; Paterno, Jussi J.; Hyttinen, Juha M.T.; Koskela, Ali; Chen, Mei; Leinonen, Henri; Tanila, Heikki; Kivinen, Niko; Koistinen, Arto; Toropainen, Elisa; Amadio, Marialaura; Smedowski, Adrian; Reinisalo, Mika; Winiarczyk, Mateusz; Mackiewicz, Jerzy; Mutikainen, Maija; Ruotsalainen, Anna-Kaisa; Kettunen, Mikko; Jokivarsi, Kimmo; Sinha, Debasish; Kinnunen, Kati; Petrovski, Goran; Blasiak, Janusz; Bjørkøy, Geir; Koskelainen, Ari; Skottman, Heli; Urtti, Arto; Salminen, Antero; Kannan, Ram; Ferrington, Deborah A.; Xu, Heping; Levonen, Anna-Liisa; Tavi, Pasi; Kauppinen, Anu; Kaarniranta, Kai (Journal article; Peer reviewed, 2019)
      Age-related macular degeneration (AMD) is a multi-factorial disease that is the leading cause of irreversible and severe vision loss in the developed countries. It has been suggested that the pathogenesis of dry AMD involves ...
    • Metodeetablering av long-range PCR for nøyaktig påvisning av klinisk relevante varianter i PRSS1-genet. 

      Skulberg, Magnus Barnholt; Andreassen, Kristoffer Emil (Bachelor thesis, 2020)
      Trypsinogen er et proenzym som omdannes til det viktige fordøyelsesenzymet trypsin i mange arter, deriblant mennesket. Genene som koder for de tre isoformene til trypsinogen er serin protease 1, 2 og 3, forkortet PRSS1, ...
    • Monitoring protein synthesis and degradation by metabolic AHA labeling and click chemistry based detection 

      Gärtner, Hanne Holm (Master thesis, 2014)
      The proteome determines the biochemical reactions that can be carried out by the cell, and is thus highly dynamic and tightly regulated by protein synthesis and degradation for adaption to environmental cues and cellular ...
    • MRI Reveals the in Vivo Cellular and Vascular Response to BEZ235 in Ovarian Cancer Xenografts with Different PI3-Kinase Pathway Activity 

      Cebulla, Jana; Huuse-Røneid, Else Marie; Pettersen, Kristine; van der Veen, Anna; Kim, Eugene; Andersen, Sonja; Prestvik, Wenche S; Bofin, Anna M.; Pathak, Arvind P; Bjørkøy, Geir; Bathen, Tone Frost; Moestue, Siver Andreas (Journal article; Peer reviewed, 2014-12-23)
      Background: The phosphoinositide-3 kinase (PI3K) pathway is an attractive therapeutic target. However, difficulty in predicting therapeutic response limits the clinical implementation of PI3K inhibitors. This study evaluates ...