Browsing NTNU Open by Author "Bjørkøy, Geir"
Now showing items 1-20 of 41
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A Novel Truncated Form of Nephronectin Is Present in Small Extracellular Vesicles Isolated from 66cl4 Cells
Toraskar, Jimita Prashant; Norvoll Magnussen, Synnøve; Hagen, Lars; Sharma, Animesh; Hoang, Linh; Bjørkøy, Geir; Svineng, Gunbjørg; Steigedal, Tonje S. (Journal article; Peer reviewed, 2019)Extracellular vesicles are emerging as biomarkers in breast cancer. Our recent report suggested that an intracellular granular staining pattern of the extracellular matrix protein nephronectin (NPNT) in breast tumor sections ... -
Analysis of interaction of murine 66cl4 and 67NR breast carcinomas with tumor-associated macrophages
Wolowczyk, Camilla Izabel (Master thesis, 2016)Breast cancer is the most common cancer among women in the world, and death is usually caused by metastasis. A tumor is a heterogeneous mass of different cells, and the tumor microenvironment is complex with extensive ... -
Autocrine activin A signalling in ovarian cancer cells regulates secretion of interleukin 6, autophagy, and cachexia
Pettersen, Kristine; Andersen, Sonja Benedikte; van der Veen, Anna; Nonstad, Unni; Hatakeyema, Shinji; Lambert, Christian; Lach-Trifilieff, Estelle; Moestue, Siver Andreas; Kim, Jana; Grønberg, Bjørn Henning; Schilb, Alain; Jacobi, Carsten; Bjørkøy, Geir (Journal article; Peer reviewed, 2019)Background The majority of patients with advanced cancer develop cachexia, a weight loss syndrome that severely reduces quality of life and limits survival. Our understanding of the underlying mechanisms that cause the ... -
Autophagy as a Survival Mechanism or a Cause of Disease
Pettersen, Kristine (Doctoral thesis at NTNU;2016:52, Doctoral thesis, 2016)Proper turnover of cellular components is crucial for all cells. If damaged or excessive content in the cell is not removed at a sufficient pace, normal cell functions may be compromised. The same may occur if the ... -
Autophagy in tissues and solid tumors controlled by infiltrating immune cells
Lamsal, Apsana (Doctoral theses at NTNU;2023:189, Doctoral thesis, 2023)Nye angrepspunkter for målrettet behandling av aggressiv kreft Brystkreft er en av de mest utbredte kreftformene og vi har i dag gode behandlingsformer. Hos noen brystkreftpasienter vil likevel kreftceller sprer seg ... -
Bone morphogenetic protein 4 and Gremlin-1 communication between mouse breast cancer cells and fibroblasts
Appiah, Christiana Opokuaah (Master thesis, 2016)Breast cancer (BC) metastasis is the leading cause of death in breast cancer patients. Interactions between breast cancer tumors and stromal cells allow the microenvironment surrounding the tumor to co-evolve into an ... -
Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling
Pettersen, Kristine; Andersen, Sonja Benedikte; Degen, simone; Tadini, Valentina; Grosjean, Joel; Hatakeyama, Shinji; Tesfahun, Almaz Nigatu; Moestue, Siver Andreas; Kim, Jana; Nonstad, Unni; Romundstad, Pål Richard; Skorpen, Frank; Sørhaug, Sveinung; Amundsen, Tore; Grønberg, Bjørn Henning; Strasser, Florian; Stephens, Nathan; Hoem, Dag; Molven, Anders; Kaasa, Stein; Fearon, Kenneth; Jacobi, Carsten; Bjørkøy, Geir (Journal article; Peer reviewed, 2017)The majority of cancer patients with advanced disease experience weight loss, including loss of lean body mass. Severe weight loss is characteristic for cancer cachexia, a condition that significantly impairs functional ... -
Characterization of birinapant-induced cell death in human monocytes and macrophage subtypes
Klaharn, Merisa (Master thesis, 2019)Macrophages play various roles in the body depending on the environment they reside due to their diversity and plasticity. Distinct functional phenotypes operate specific tasks, ranging from inflammation and host defense ... -
Cyclic Arginine–Glycine–Aspartate-Decorated Lipid Nanoparticle Targeting toward Inflammatory Lesions Involves Hitchhiking with Phagocytes
Sofias, Alexandros Marios; Bjørkøy, Geir; Ochando, Jordi; Sønstevold, Linda; Hegvik, Maria; Davies, Catharina de Lange; Haraldseth, Olav; Lammers, Twan; Mulder, Willem J. M.; Hak, Sjoerd (Peer reviewed; Journal article, 2021)Active-targeting nanomedicine formulations have an intricate in vivo behavior. Nanomedicines developed to target endothelial αvβ3-integrin are recently demonstrated to display extensive uptake by circulating phagocytes. ... -
Depletion of the human N-terminal acetyltransferase hNaa30 disrupts Golgi integrity and ARFRP1 localization
Starheim, Kristian K.; Kalvik, Thomas Vikestad; Bjørkøy, Geir; Arnesen, Thomas (Journal article; Peer reviewed, 2017)The organization of the Golgi apparatus (GA) is tightly regulated. Golgi stack scattering is observed in cellular processes such as apoptosis and mitosis, and has also been associated with disruption of cellular lipid ... -
Developing quantitative imaging of Akt activation in tissue sections
Dam, Cornelia Gerarda (Master thesis, 2012)The PI3K/mTOR pathway regulates fundamental cellular processes such as proliferation, growth, metabolism and autophagy. PI3K signalling is often constitutively activated in cancer cells and tumours. Chemical inhibitors ... -
DHA-induced stress response in human colon cancer cells - Focus on oxidative stress and autophagy
Pettersen, Kristine; Monsen, Vivi Anita Talstad; Pettersen, Caroline Hild; Overland, Hilde Bremseth; Pettersen, Grete Klippenvåg; Samdal, Helle; Tesfahun, Almaz Nigatu; Lundemo, Anne Gøril; Bjørkøy, Geir; Schønberg, Svanhild Margrethe Arentz (Journal article; Peer reviewed, 2016)Polyunsaturated fatty acids (PUFAs) are important constituents of the diet and health benefits of omega-3/n−3 PUFAs, especially eicosapentaenoic acid (EPA, 20:5 n−3) and docosahexaenoic acid (DHA, 22:6 n−3) have been well ... -
DHA-induced stress response in human colon cancer cells - Focus on oxidative stress and autophagy
Pettersen, Kristine; Monsen, Vivi Anita Talstad; Pettersen, Caroline Hild; Overland, Hilde Bremseth; Pettersen, Grete Klippenvåg; Samdal, Helle; Tesfahun, Almaz Nigatu; Lundemo, Anne Gøril; Bjørkøy, Geir; Schønberg, Svanhild Margrethe Arentz (Journal article; Peer reviewed, 2016) -
Discovery of a new marker to identify myeloid cells associated with metastatic breast tumours
Bokil, Ansooya Avinash; Børkja, Mathieu; Wolowczyk, Camilla Izabel; Lamsal, Apsana; Prestvik, Wenche S.; Nonstad, Unni; Pettersen, Kristine; Andersen, Sonja Benedikte; Bofin, Anna M.; Bjørkøy, Geir; Hak, Sjoerd; Giambelluca, Miriam Soledad (Peer reviewed; Journal article, 2023)Background: Myeloid cells play an essential role in cancer metastasis. The phenotypic diversity of these cells during cancer development has attracted great interest; however, their functional heterogeneity and plasticity ... -
Exploring the effect of arginine starvation on autophagy and type I IFN response in cancer cells
Rylander, Eva Felicia (Master thesis, 2021)Female breast cancer is now estimated to be the most diagnosed cancer, accounting for 11.7% of all cancer cases worldwide. Tumors are heterogenous tissues consisting of various types of cells together creating the tumor ... -
Gastrin activates autophagy and increases migration and survival of gastric adenocarcinoma cells
Rao, Shalini; Solum, Guri; Niederdorfer, Barbara; Nørsett, Kristin; Bjørkøy, Geir; Thommesen, Liv (Journal article; Peer reviewed, 2017)Background: The peptide hormone gastrin exerts a growth-promoting effect in both normal and malignant gastrointestinal tissue. Gastrin mediates its effect via the cholecystokinin 2 receptor (CCKBR/CCK2R). Although a ... -
GREM1 is associated with metastasis and predicts poor prognosis in ER-negative breast cancer patients
Neckmann, Ulrike; Wolowczyk, Camilla; Hall, Martina; Almaas, Eivind; Ren, Jiang; Zhao, Sen; Johannessen, Bjarne; Skotheim, Rolf I.; Bjørkøy, Geir; Dijke, Peter Ten; Holien, Toril (Journal article; Peer reviewed, 2019)Background In breast cancer, activation of bone morphogenetic protein (BMP) signaling and elevated levels of BMP-antagonists have been linked to tumor progression and metastasis. However, the simultaneous upregulation of ... -
Heterogeneity within the 66cl4 cell line from the 4T1 model of metastatic breast cancer
Tran, Tuong Vy Thi (Master thesis, 2018)Breast cancer is one of the most common form of cancer among women globally and metastasis is the primary cause of death in breast cancer patients. In the past decades it has been increasingly known that tumors are ... -
A highly selective purine-based inhibitor of CSF1R potently inhibits osteoclast differentiation
Aarhus, Thomas Ihle; Eickhoff, Jan; Klebl, Bert; Unger, Anke; Boros, Johanna; Choidas, Axel; Zischinsky, Mia-Lisa; Wolowczyk, Camilla Izabel; Bjørkøy, Geir; Sundby, Eirik; Hoff, Bård Helge (Peer reviewed; Journal article, 2023)The colony-stimulating factor 1 receptor (CSF1R) plays an important role in the regulation of many inflammatory processes, and overexpression of the kinase is implicated in several disease states. Identifying selective, ... -
Identification of NRF2 binding sites in metastatic breast cancer cells by ChIP-Seq
Shin, Yuna (Master thesis, 2021)Background: Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that is indicated to be an important component in promoting cancer metastasis. Accordingly, the role of the transcription factor has ...