Browsing NTNU Open by Author "Bjørkøy, Astrid"
Now showing items 1-14 of 14
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Augmenting drug-carrier compatibility improves tumour nanotherapy efficacy
Zhao, Yiming; Fay, Francois; Hak, Sjoerd; Manuel Perez-Aguilar, Jose; Sanchez-Gaytan, Brenda L; Goode, Brandon; Duivenvoorden, Raphael; Davies, Ruth Catharina de Lange; Bjørkøy, Astrid; Weinstein, Harel; Fayad, Zahi A; Perez-Medina, Carlos; Mulder, Willem J M (Journal article; Peer reviewed, 2016)A major goal of cancer nanotherapy is to use nanoparticles as carriers for targeted delivery of anti-tumour agents. The drug–carrier association after intravenous administration is essential for efficient drug delivery to ... -
Confocal reflectance microscopy and multiple particle tracking for the study of the gelation of biopolymers
Haug, Bente; Nordgård, Catherine Taylor; Draget, Kurt Ingar; Bjørkøy, Astrid (Journal article; Peer reviewed, 2018)The combination of confocal reflectance imaging (CRM) and simultaneous multiple particle tracking (MPT) with mean-square displacement (MSD) analysis is a new method for studying the gelation of biopolymers. In addition to ... -
Effect of acoustic radiation force on displacement of nanoparticles in collagen gels
Løvmo, Mia Kvåle; Yemane, Petros Tesfamichael; Bjørkøy, Astrid; Hansen, Rune; Cleveland, Robin O.; Angelsen, Bjørn Atle Johan; Davies, Catharina de Lange (Peer reviewed; Journal article, 2020)Penetration of nanoscale therapeutic agents into the extracellular matrix (ECM) of a tumor is a limiting factor for the sufficient delivery of drugs in tumors. Ultrasound (US) in combination with microbubbles causing ... -
Effect of Acoustic Radiation Force on the Distribution of Nanoparticles in Solid Tumors.
Afadzi, Mercy; Myhre, Ola Finneng; Yemane, Petros Tesfamichael; Bjørkøy, Astrid; Torp, Sverre Helge; van Wamel, Annemieke; Lelu, Sylvie; Angelsen, Bjørn Atle Johan; Davies, Catharina de Lange (Peer reviewed; Journal article, 2020)Acoustic radiation force (ARF) might improve the distribution of nanoparticles (NPs) in tumors. To study this, tumors growing subcutaneously in mice were exposed to focused ultrasound (FUS) either 15 min or 4 h after the ... -
Effect of ultrasound on the vasculature and extravasation of nanoscale particles imaged in real time
Yemane, Petros Tesfamichael; Åslund, Andreas K. O.; Snipstad, Sofie; Bjørkøy, Astrid; Grendstad, Kristin; Berg, Sigrid; Mørch, Ýrr Asbjørg; Torp, Sverre Helge; Hansen, Rune; Davies, Catharina de Lange (Journal article; Peer reviewed, 2019)Ultrasound and microbubbles have been found to improve the delivery of drugs and nanoparticles to tumor tissue. To obtain new knowledge on the influence of vascular parameters on extravasation and to elucidate the effect ... -
Localization of Novel Chlorin Photosensitizers and Commercial Stains in the AY-27 Cell Model Using Advanced Fluorescence Microscopy
Bergvoll, Johannes Kjeldsen (Master thesis, 2021)Gjennom et samarbeid mellom Linköping Universitet og Norges Tekniske og Naturvitenskapelige Universitet, har flere nye kloriner for bruk i fotodynamisk terapi blitt syntetisert. To av disse klorinene, KA20-11H og KA20-11H-proto ... -
Mechanical Confinement and DDR1 Signaling Synergize to Regulate Collagen-Induced Apoptosis in Rhabdomyosarcoma Cells
Gonzalez-Molina, Jordi; Kirchhof, Katharina Miria; Rathod, Bhavik; Moyano-Galceran, Lidia; Calvo-Noriega, Maria; Kokaraki, Georgia; Bjørkøy, Astrid; Ehnman, Monika; Carlson, Joseph W.; Lehti, Kaisa (Journal article; Peer reviewed, 2022) -
Mechanical Properties of Poly(Alkyl Cyanoacrylate) Nanoparticles Measured by Atomic Force Microscopy
Grøneng, Ola Haugen (Master thesis, 2018)With the use of Poly(Alkyl Cyanoacrylate) nanoparticles as drug carriers in ultrasound mediated cancer therapy, it is desirable to know the mechanical properties(Young's Modulus) of the particles to be able to predict their ... -
Quantitative 3-D colocalization analysis as a tool to study the intracellular trafficking and dissociation of pDNA-chitosan polyplexes
Reitan, Nina Kristine; Sporsheim, Bjørnar; Bjørkøy, Astrid; Strand, Sabina P.; Davies, Catharina De Lange (Journal article; Peer reviewed, 2012)Multichannel microscopy is frequently used to study intermolecular interactions and spatial relationships between biomolecules and organelles or vesicles in cells. Based on multichannel images, quantitative colocalization ... -
Recovering fluorophore concentration profiles from confocal images near lateral refractive index step changes
Parelius Jonasova, Eleonora; Bjørkøy, Astrid; Stokke, Bjørn Torger (Peer reviewed; Journal article, 2016)Optical aberrations due to refractive index mismatches occur in various types of microscopy due to refractive differences between the sample and the immersion fluid or within the sample. We study the effects of lateral ... -
Sonoporation using nanoparticle-loaded microbubbles increases cellular uptake of nanoparticles compared to co-incubation of nanoparticles and microbubbles
Snipstad, Sofie; Hanstad, Sigurd; Bjørkøy, Astrid; Mørch, Ýrr Asbjørg; Davies, Catharina de Lange (Peer reviewed; Journal article, 2021)Therapeutic agents can benefit from encapsulation in nanoparticles, due to improved pharmacokinetics and biodistribution, protection from degradation, increased cellular uptake and sustained release. Microbubbles in ... -
The Effect of Sonication on Extravasation and Distribution of Nanoparticles and Dextrans in Tumor Tissue Imaged by Multiphoton Microscopy
Yemane, Petros Tesfamichael; Åslund, Andreas; Sæterbø, Kristin Grendstad; Bjørkøy, Astrid; Snipstad, Sofie; van Wamel, Annemieke; Berg, Sigrid; Mørch, Ýrr Asbjørg; Hansen, Rune; Angelsen, Bjørn Atle Johan; Davies, Catharina de Lange (Journal article; Peer reviewed, 2018)Ultrasound (US)and systemic administration of microbubbles (MBs)have been shown to improve the delivery of drugs and nanoparticles (NPs)to tumor tissue. A better understanding of the mechanisms is crucial for effective ... -
Toehold length of target ssDNA affects reaction-diffusion behavior in DNA-responsive DNA-co-acrylamide hydrogels
Jonasova, Eleonora Parelius; Bjørkøy, Astrid; Stokke, Bjørn Torger (Peer reviewed; Journal article, 2020)In the present study, we expand on the understanding of hydrogels with embedded deoxyribonucleic acid (DNA) cross-links, from the overall swelling to characterization of processes that precede the swelling. The hydrogels ... -
Ultrasound Improves the Delivery and Therapeutic Effect of Nanoparticle-Stabilized Microbubbles in Breast Cancer Xenografts
Snipstad, Sofie; Berg, Sigrid; Mørch, Ýrr Asbjørg; Bjørkøy, Astrid; Sulheim, Einar; Hansen, Rune; Grimstad, Ingeborg; van Wamel, Annemieke; Maaland, Astri Fjelde; Torp, Sverre Helge; Davies, Ruth Catharina de Lange (Journal article; Peer reviewed, 2017)Compared with conventional chemotherapy, encapsulation of drugs in nanoparticles can improve efficacy and reduce toxicity. However, delivery of nanoparticles is often insufficient and heterogeneous because of various ...