Browsing NTNU Open by Author "Björklund, Anneli"
Now showing items 1-7 of 7
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A 1-year pilot study of intralymphatic injections of GAD-alum in individuals with latent autoimmune diabetes in adults (LADA) with signs of high immunity: No safety concerns and resemblance to juvenile type 1 diabetes
Hals, Ingrid Kathrin; Balasuriya, Chandima Nirupa Dilruks; Casas, Rosaura; Ludvigsson, Johnny; Björklund, Anneli; Grill, Valdemar Erik Robert (Peer reviewed; Journal article, 2023)Aims To test, for the first time in latent autoimmune diabetes in adults (LADA), the effects of autoantigen-specific immunotherapy by intralymphatic administration of aluminium-formulated recombinant human glutamic acid ... -
Hyperoxia reduces insulin release and induces mitochondrial dysfunction with possible implications for hyperoxic treatment of neonates
Hals, Ingrid Kathrin; Ohki, Tsuyoshi; Singh, Rinku; Ma, Zuheng; Björklund, Anneli; Balasuriya, Chandima Nirupa Dilruks; Scholz, Hanne; Grill, Valdemar Erik Robert (Journal article; Peer reviewed, 2017)We previously showed that hyperoxia in vitro negatively affects beta cells of the rat. Here, we tested for possible clinical significance as well as mitochondrial interactions by hyperoxia, using human islets (function and ... -
Investigating optimal β-cell-preserving treatment in latent autoimmune diabetes in adults: Results from a 21-month randomized trial
Hals, Ingrid Kathrin; Fleiner, Hanne Fiskvik; Reimers, Nina; Astor, Marianne; Filipsson, Karin; Ma, Zuheng; Grill, Valdemar Erik Robert; Björklund, Anneli (Peer reviewed; Journal article, 2019)Aims To compare outcomes of glucagon‐stimulated C‐peptide tests (GSCTs) in people with latent autoimmune diabetes in adults (LADA) after a 21‐month intervention with either insulin or the dipeptidyl peptidase‐4 inhibitor ... -
Latent Autoimmune Diabetes in Adults: Background, Safety and Feasibility of an Ongoing Pilot Study With Intra-Lymphatic Injections of GAD-Alum and Oral Vitamin D
Björklund, Anneli; Hals, Ingrid Kathrin; Grill, Valdemar Erik Robert; Ludvigsson, Johnny (Peer reviewed; Journal article, 2022)Background: Latent Autoimmune Diabetes in Adults (LADA) constitutes around 10% of all diabetes. Many LADA patients gradually lose their insulin secretion and progress to insulin dependency. In a recent trial BALAD (Behandling ... -
Mitochondrial Respiration in Insulin-Producing β-Cells: General Characteristics and Adaptive Effects of Hypoxia
Hals, Ingrid Katrin; Bruerberg, Simon Gustafson; Ma, Zuheng; Scholz, Hanne; Björklund, Anneli; Grill, Valdemar Erik Robert (Journal article; Peer reviewed, 2015)Objective: To provide novel insights on mitochondrial respiration in β-cells and the adaptive effects of hypoxia. Methods and Design Insulin-producing INS-1 832/13 cells were exposed to 18 hours of hypoxia followed by ... -
Time-dependent effects on circulating cytokines in patients with LADA: A decrease in IL-1ra and IL-1 beta is associated with progressive disease
Hals, Ingrid Kathrin; Björklund, Anneli; Fleiner, Hanne Fiskvik; Grill, Valdemar Erik Robert (Peer reviewed; Journal article, 2022)Background Cytokines and chemokines participate in autoimmune processes at cellular targets which include insulin-producing beta cells. To which extent such participation is reflected in the circulation has not been ... -
Time-dependent effects on circulating cytokines in patients with LADA: A decrease in IL1-ra and IL-1 beta is associated with progressive disease
Hals, Ingrid Kathrin; Björklund, Anneli; Fleiner, Hanne Fiskvik; Grill, Valdemar Erik Robert (Peer reviewed; Journal article, 2022)Background - Cytokines and chemokines participate in autoimmune processes at cellular targets which include insulin-producing beta cells. To which extent such participation is reflected in the circulation has not been ...