Blar i NTNU Open på forfatter "Binder, Elisabeth B."
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Betamethasone administration during pregnancy is associated with placental epigenetic changes with implications for inflammation
Czamara, Darina; Dieckmann, Linda; Röh, Simone; Kraemer, Sarah; Rancourt, Rebecca C.; Sammallahti, Sara; Kajantie, Eero Olavi; Laivuori, Hannele; Eriksson, Johan G.; Räikkönen, Katri; Henrich, Wolfgang; Plagemann, Andreas; Binder, Elisabeth B.; Braun, Thorsten; Entringer, Sonja (Peer reviewed; Journal article, 2021)Background Glucocorticoids (GCs) play a pivotal role in fetal programming. Antenatal treatment with synthetic GCs (sGCs) in individuals in danger of preterm labor is common practice. Adverse short- and long-term effects ... -
Characteristics of epigenetic aging across gestational and perinatal tissues
Dieckmann, Linda; Lahti-Pulkkinen, Marius; Kvist, Tuomas; Lahti, Jari; DeWitt, Peter E.; Cruceanu, Cristiana; Laivuori, Hannele; Sammallahti, Sara; Villa, Pia M.; Suomalainen-König, Sanna; Eriksson, Johan G.; Kajantie, Eero Olavi; Raikkönen, Katri; Binder, Elisabeth B.; Czamara, Darina (Peer reviewed; Journal article, 2021)Background: Epigenetic clocks have been used to indicate differences in biological states between individuals of same chronological age. However, so far, only few studies have examined epigenetic aging in newborns—especially ... -
Genome-Wide Copy Number Variant and High-Throughput Transcriptomics Analyses of Placental Tissues Underscore Persisting Child Susceptibility in At-Risk Pregnancies Cleared in Standard Genetic Testing
Czamara, Darina; Cruceanu, Cristiana; Lahti-Pulkkinen, Marius; Dieckmann, Linda; Ködel, Maik; Sauer, Susann; Rex-Haffner, Monika; Sammallahti, Sara; Kajantie, Eero Olavi; Laivuori, Hannele; Lahti, Jari; Räikkönen, Katri; Binder, Elisabeth B. (Peer reviewed; Journal article, 2022)Several studies have shown that children from pregnancies with estimated first-trimester risk based on fetal nuchal translucency thickness and abnormal maternal serum pregnancy protein and hormone levels maintain a higher ... -
GWAS of suicide attempt in psychiatric disorders and association with major depression polygenic risk scores
Mullins, Niamh; Bigdeli, Tim B.; Børglum, Anders D.; Coleman, Jonathan R.I.; Demontis, Ditte; Mehta, Divya; Power, Robert A.; Ripke, Stephan; Stahl, Eli A.; Starnawska, Anna; Anjorin, Adebayo; Corvin, Aiden; Sanders, Alan R.; Forstner, Andreas J.; Reif, Andreas; Koller, Anna C.; Świątkowska, Beata; Baune, Bernhard T.; Müller-Myhsok, Bertram; Penninx, Brenda W.J.H.; Pato, Carlos; Zai, Clement; Rujescu, Dan; Hougaard, David M.; Quested, Digby; Levinson, Douglas F.; Binder, Elisabeth B.; Byrne, Enda M.; Agerbo, Esben; Streit, Fabian; Mayoral, Fermin; Bellivier, Frank; Degenhardt, Franziska; Breen, Gerome; Morken, Gunnar; Turecki, Gustavo; Rouleau, Guy A.; Grabe, Hans J.; Völzke, Henry; Jones, Ian; Giegling, Ina; Agartz, Ingrid; Melle, Ingrid; Lawrence, Jacob; Walters, James T.R.; Strohmaier, Jana; Shi, Jianxin; Hauser, Joanna; Biernacka, Joanna M.; Vincent, John B.; Kelsoe, John; Strauss, John S.; Lissowska, Jolanta; Pimm, Jonathan; Smoller, Jordan W.; Guzman-Parra, José; Berger, Klaus; Scott, Laura J.; Jones, Lisa A.; Azevedo, M. Helena; Trzaskowski, Maciej; Kogevinas, Manolis; Rietschel, Marcella; Boks, Marco; Ising, Marcus; Grigoroiu-Serbanescu, Maria; Hamshere, Marian L.; Leboyer, Marion; Frye, Mark; Nöthen, Markus M.; Alda, Martin; Preisig, Martin; Nordentoft, Merete; Boehnke, Michael; O'Donovan, Michael C.; Owen, Michael J.; Pato, Michele T.; Renteriá, Miguel E.; Budde, Monika; Weissman, Myrna M.; Wray, Naomi R.; Bass, Nicholas; Craddock, Nicholas; Smeland, Olav Bjerkehagen; Andreassen, Ole Andreas; Mors, Ole; Gejman, Pablo V.; Sklar, Pamela; McGrath, Patrick; Hoffmann, Per; McGuffin, Peter; Lee, Phil H.; Mortensen, Preben Bo; Kahn, René S.; Ophoff, Roel A.; Adolfsson, Rolf; Van der Auwera, Sandra; Djurovic, Srdjan; Kloiber, Stefan; Heilmann-Heimbach, Stefanie; Jamain, Stéphane; Hamilton, Steven P.; McElroy, Susan L.; Lucae, Susanne; Cichon, Sven; Schulze, Thomas G.; Hansen, Thomas; Werge, Thomas; Air, Tracy M.; Nimgaonkar, Vishwajit; Appadurai, Vivek; Cahn, Wiepke; Milaneschi, Yuri; Fanous, Ayman H.; Kendler, Kenneth S.; McQuillin, Andrew; Lewis, Cathryn M. (Journal article; Peer reviewed, 2019)Objective: More than 90% of people who attempt suicide have a psychiatric diagnosis; however, twin and family studies suggest that the genetic etiology of suicide attempt is partially distinct from that of the psychiatric ... -
Maternal exposure to childhood maltreatment and mental and behavioral disorders in children
Airikka, Aino; Lahti-Pulkkinen, Marius; Tuovinen, Soile; Heinonen, Kati; Lahti, Jari; Girchenko, Polina; Lähdepuro, Anna; Pyhälä, Riikka; Czamara, Darina; Villa, Pia; Laivuori, Hannele; Kajantie, Eero Olavi; Binder, Elisabeth B.; Räikkönen, Katri (Peer reviewed; Journal article, 2022)Exposure to maltreatment in childhood is associated with lifelong risk of mental and behavioral disorders. Whether the effects extend to the next generation remains unclear. We examined whether maternal exposure to childhood ... -
Maternal haemoglobin levels in pregnancy and child DNA methylation: a study in the pregnancy and childhood epigenetics consortium
Ronkainen, Justiina; Heiskala, Anni; Vehmeijer, Florianne O.; Lowry, Estelle; Caramaschi, Doretta; Estrada Gutierrez, Guadalupe; Heiss, Jonathan A.; Hummel, Nadine; Keikkala, Elina; Kvist, Tuomas; Kupsco, Allison; Melton, Phillip E.; Pesce, Giancarlo; Soomro, Munawar Hussain; Vives-Usano, Marta; Baïz, Nour; Binder, Elisabeth B.; Czamara, Darina; Guxens, Mònica; Mustaniemi, Sanna; London, Stephanie J.; Rauschert, Sebastian; Vääräsmäki, Marja; Vrijheid, Martine; Ziegler, Anette-G.; Annesi-Maesano, Isabella; Bustamante, Mariona; Huang, Rae-Chi; Hummel, Sandra; Just, Allan C.; Kajantie, Eero Olavi; Lahti, Jari; Lawlor, Debbie A.; Räikkönen, Katri; Jarvelin, Marjo-Riitta; Felix, Janine F.; Sebert, Sylvain (Peer reviewed; Journal article, 2021)Altered maternal haemoglobin levels during pregnancy are associated with pre-clinical and clinical conditions affecting the fetus. Evidence from animal models suggests that these associations may be partially explained by ... -
A polyepigenetic glucocorticoid exposure score at birth and childhood mental and behavioral disorders
Suarez, Anna; Lahti, Jari; Lahti-Pulkkinen, Marius; Girchenko, Polina; Czamara, Darina; Arloth, Janine; Malmberg, Anni LK.; Hämäläinen, Esa; Kajantie, Eero Olavi; Laivuori, Hannele; Villa, Pia M.; Reynolds, Rebecca M.; Provençal, Nadine; Binder, Elisabeth B.; Räikkönen, Katri (Peer reviewed; Journal article, 2020)Background Maternal depression and anxiety during pregnancy may enhance fetal exposure to glucocorticoids (GCs) and harm neurodevelopment. We tested whether a novel cross-tissue polyepigenetic biomarker indicative of in ... -
Reliability of a novel approach for reference-based cell type estimation in human placental DNA methylation studies
Dieckmann, Linda; Cruceanu, Cristiana; Lahti-Pulkkinen, Marius; Lahti, Jari; Kvist, Tuomas; Laivuori, Hannele; Sammallahti, Sara; Villa, Pia M.; Suomalainen-König, Sanna; Rancourt, Rebecca C.; Plagemann, Andreas; Henrich, Wolfgang; Eriksson, Johan G.; Kajantie, Eero Olavi; Entringer, Sonja; Braun, Thorsten; Räikkönen, Katri; Binder, Elisabeth B.; Czamara, Darina (Peer reviewed; Journal article, 2022)The placenta is a central organ during early development, influencing trajectories of health and disease. DNA methylation (DNAm) studies of human placenta improve our understanding of how its function relates to disease ...