• Are the Neuroprotective Effects of Exercise Training Systemically Mediated? 

      Tari, Atefe R; Norevik, Cecilie Skarstad; Scrimgeour, Nathan Robert; Kobro-Flatmoen, Asgeir; Storm-Mathisen, Jon; Bergersen, Linda Hildegard; Wrann, Christiane D; Selbæk, Geir; Kivipelt, Miia; Moreira, Jose Bianco Nascimento; Wisloff, Ulrik (Journal article; Peer reviewed, 2019)
      To date there is no cure available for dementia, and the field calls for novel therapeutic targets. A rapidly growing body of literature suggests that regular endurance training and high cardiorespiratory fitness attenuate ...
    • Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1 

      Morland, Cecilie; Andersson, Krister; Haugen, Øyvind Pernell; Hadzic, Alena; Kleppa, Liv; Gille, Andreas; Rinholm, Johanne Egge; Palibrk, Vuk; Diget, Elisabeth Holm; Kennedy, Lauritz Hagen; Stølen, Tomas; Hennestad, Eivind; Moldestad, Olve; Cai, Yiqing; Puchades, Maja Amedjkouh; Offermanns, Stefan; Vervaeke, Koen Gerard Alois; Bjørås, Magnar; Wisløff, Ulrik; Storm-Mathisen, Jon; Bergersen, Linda Hildegard (Journal article; Peer reviewed, 2017)
      Physical exercise can improve brain function and delay neurodegeneration; however, the initial signal from muscle to brain is unknown. Here we show that the lactate receptor (HCAR1) is highly enriched in pial fibroblast-like ...
    • Exercised blood plasma promotes hippocampal neurogenesis in the Alzheimer's disease rat brain 

      Norevik, Cecilie Skarstad; Huuha, Aleksi Matias; Røsbjørgen, Ragnhild; Bergersen, Linda Hildegard; Jacobsen, Kamilla; Miguel dos Santos, Rodrigo; Ryan, Liv; Skender, Belma; Bianco Nascimento Moreira, Jose; Kobro-Flatmoen, Asgeir; Witter, Menno Peter; Scrimgeour, Nathan Robert; Rafiee Tari, Atefe (Peer reviewed; Journal article, 2023)
      Background Exercise training promotes brain plasticity and is associated with protection against cognitive impairment and Alzheimer's disease (AD). These beneficial effects may be partly mediated by blood-borne factors. ...
    • High intensity interval training ameliorates mitochondrial dysfunction in the left ventricle of mice with type 2 diabetes 

      Bækkerud, Fredrik Hjulstad; Salerno, Simona; Ceriotti, Paola; Morland, Cecilie; Storm-Mathisen, Jon; Bergersen, Linda Hildegard; Høydal, Morten; Catalucci, Daniele; Stølen, Tomas (Journal article; Peer reviewed, 2019)
      UNIKARD (Project Number 217777/H10)
    • Lactate receptor HCAR1 regulates neurogenesis and microglia activation after neonatal hypoxia-ischemia 

      Kennedy, Lauritz Hagen; Glesaaen, Emilie Rylund; Palibrk, Vuk; Pannone, Marco; Wang, Wei; Al-Jabri, Ali; Suganthan, Rajikala; Meyer, Niklas; Austbø, Marie Landa; Lin, Xiaolin; Bergersen, Linda Hildegard; Bjørås, Magnar; Rinholm, Johanne Egge (Peer reviewed; Journal article, 2022)
      Neonatal cerebral hypoxia-ischemia (HI) is the leading cause of death and disability in newborns with the only current treatment being hypothermia. An increased understanding of the pathways that facilitate tissue repair ...