Browsing NTNU Open by Author "Berg, Sigrid"
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Capacitive micromachined ultrasonic transducers: Acoustic challenges and proposed solutions
Berg, Sigrid (Doktoravhandlinger ved NTNU, 1503-8181; 2012:141, Doctoral thesis, 2012)Capacitive Micromachined Ultrasonic Transducer (CMUT) have been subject to research by several research groups during the last two decades. Despite many potential advantages over traditional piezoelectric ultrasound ... -
Effect of ultrasound on the vasculature and extravasation of nanoscale particles imaged in real time
Yemane, Petros Tesfamichael; Åslund, Andreas K. O.; Snipstad, Sofie; Bjørkøy, Astrid; Grendstad, Kristin; Berg, Sigrid; Mørch, Ýrr Asbjørg; Torp, Sverre Helge; Hansen, Rune; Davies, Catharina de Lange (Journal article; Peer reviewed, 2019)Ultrasound and microbubbles have been found to improve the delivery of drugs and nanoparticles to tumor tissue. To obtain new knowledge on the influence of vascular parameters on extravasation and to elucidate the effect ... -
Formulation and characterisation of drug-loaded antibubbles for image-guided and ultrasound-triggered drug delivery
Kotopoulis, Spiros; Lam, Christina; Haugse, Ragnhild; Snipstad, Sofie; Murvold, Elsa Thodesen; Jouleh, Tæraneh; Berg, Sigrid; Hansen, Rune; Popa, Mihaela-Lucia; Mccormack, Emmet Matin; Gilja, Odd Helge; Poortinga, Albert (Peer reviewed; Journal article, 2022)The aim of this study was to develop high load-capacity antibubbles that can be visualized using diagnostic ultrasound and the encapsulated drug can be released and delivered using clinically translatable ultrasound. The ... -
Multi-timescale microscopy methods for the characterization of fluorescently-labeled microbubbles for ultrasound-triggered drug release
Nawijn, Charlotte; Segers, Tim; Lajoinie, Guillaume; Mørch, Ýrr Asbjørg; Berg, Sigrid; Snipstad, Sofie; Davies, Catharina de Lange; Versluis, Michel (Peer reviewed; Journal article, 2021)Microbubble contrast agents hold great promise for drug delivery applications with ultrasound. Encapsulating drugs in nanoparticles reduces systemic toxicity and increases circulation time of the drugs. In a novel approach ... -
Nanoparticle delivery to the brain - By focused ultrasound and self-assembled nanoparticle-stabilized microbubbles
Åslund, Andreas; Berg, Sigrid; Hak, Sjoerd; Mørch, Ýrr Asbjørg; Torp, Sverre Helge; Sandvig, Axel; Widerøe, Marius; Hansen, Rune; Davies, Ruth Catharina de Lange (Journal article, 2015)The blood–brain barrier (BBB) constitutes a significant obstacle for the delivery of drugs into the central nervous system (CNS). Nanoparticles have been able to partly overcome this obstacle and can thus improve drug ... -
Nanoparticle-stabilized microbubbles for multimodal imaging and drug delivery
Mørch, Ýrr Asbjørg; Hansen, Rune; Berg, Sigrid; Åslund, Andreas; Glomm, Wilhelm; Eggen, Siv; Schmid, Ruth; Johnsen, Heidi; Kubowicz, Stephan; Snipstad, Sofie; Sulheim, Einar; Hak, Sjoerd; Singh, Gurvinder; McDonagh, Birgitte Hjelmeland; Blom, Hans; Davies, Ruth Catharina de Lange; Stenstad, Per Martin (Journal article, 2015)Microbubbles (MBs) are routinely used as contrast agents for ultrasound imaging. The use of ultrasound in combination with MBs has also attracted attention as a method to enhance drug delivery. We have developed a technology ... -
Nanoparticles, ultrasound and microbubble mediated drug delivery in cancer models
Fagerland, Stein-Martin Tilrum (Doctoral theses at NTNU;2020:97, Doctoral thesis, 2020)Denne avhandlingen omhandler forbedring av kreftbehandling gjennom økt levering av cellegift til kreftvev ved bruk av nanopartikler eller ultralyd kombinert med mikrobobler. Ved å kapsle cellegift inn i nanopartikler kan ... -
Primary Porcine Brain Endothelial Cells as In Vitro Model to Study Effects of Ultrasound and Microbubbles on Blood-Brain Barrier Function
Lelu, Sylvie; Afadzi, Mercy; Berg, Sigrid; Åslund, Andreas; Torp, Sverre Helge; Sattler, Wolfgang; Davies, Ruth Catharina de Lange (Journal article; Peer reviewed, 2017)Focused ultrasound in the presence of microbubbles transiently and reversibly opens the blood-brain barrier (BBB) in rodents and humans thereby providing a time window for increased drug delivery into brain tissue. To get ... -
Sonopermeation Enhances Uptake and Therapeutic Effect of Free and Encapsulated Cabazitaxel
Snipstad, Sofie; Mørch, Ýrr; Sulheim, Einar; Åslund, Andreas; Pedersen, André; Hansen, Rune; Davies, Catharina de Lange; Berg, Sigrid (Peer reviewed; Journal article, 2021)Delivery of drugs and nanomedicines to tumors is often heterogeneous and insufficient and, thus, of limited efficacy. Microbubbles in combination with ultrasound have been found to improve delivery to tumors, enhancing ... -
The Effect of Sonication on Extravasation and Distribution of Nanoparticles and Dextrans in Tumor Tissue Imaged by Multiphoton Microscopy
Yemane, Petros Tesfamichael; Åslund, Andreas; Sæterbø, Kristin Grendstad; Bjørkøy, Astrid; Snipstad, Sofie; van Wamel, Annemieke; Berg, Sigrid; Mørch, Ýrr Asbjørg; Hansen, Rune; Angelsen, Bjørn Atle Johan; Davies, Catharina de Lange (Journal article; Peer reviewed, 2018)Ultrasound (US)and systemic administration of microbubbles (MBs)have been shown to improve the delivery of drugs and nanoparticles (NPs)to tumor tissue. A better understanding of the mechanisms is crucial for effective ... -
Ultrasound and microbubble treatment for improved delivery of nanomedicine to tumours and the brain
Olsman, Marieke (Doctoral theses at NTNU;2021:138, Doctoral thesis, 2021)The combined use of ultrasound and intravascular microbubbles, referred to as ultrasound and microbubble treatment, has emerged as a promising technique to enhance delivery of nanomedicine to tumours and the brain. Even ... -
Ultrasound and Microbubbles Increase the Uptake of Platinum in Murine Orthotopic Pancreatic Tumors
Haram, Karin Margrete; Snipstad, Sofie; Berg, Sigrid; Mjønes, Patricia; Rønne, Elin; Lage Fernandez, Jessica; Mühlenpfordt, Melina; Davies, Catharina de Lange (Peer reviewed; Journal article, 2023)Objective Currently available cytotoxic treatments have limited effect on pancreatic ductal adenocarcinoma (PDAC) because desmoplastic stroma limits drug delivery. Efforts have been made to overcome these barriers by drug ... -
Ultrasound Improves the Delivery and Therapeutic Effect of Nanoparticle-Stabilized Microbubbles in Breast Cancer Xenografts
Snipstad, Sofie; Berg, Sigrid; Mørch, Ýrr Asbjørg; Bjørkøy, Astrid; Sulheim, Einar; Hansen, Rune; Grimstad, Ingeborg; van Wamel, Annemieke; Maaland, Astri Fjelde; Torp, Sverre Helge; Davies, Ruth Catharina de Lange (Journal article; Peer reviewed, 2017)Compared with conventional chemotherapy, encapsulation of drugs in nanoparticles can improve efficacy and reduce toxicity. However, delivery of nanoparticles is often insufficient and heterogeneous because of various ... -
Ultrasound-mediated delivery and distribution of polymeric nanoparticles in the normal brain parenchyma of a metastatic brain tumour model
Baghirov, Habib; Snipstad, Sofie; Sulheim, Einar; Berg, Sigrid; Hansen, Rune; Thorsen, Frits; Mørch, Ýrr Asbjørg; Davies, Catharina de Lange; Åslund, Andreas (Journal article; Peer reviewed, 2018)The treatment of brain diseases is hindered by the blood-brain barrier (BBB) preventing most drugs from entering the brain. Focused ultrasound (FUS) with microbubbles can open the BBB safely and reversibly. Systemic drug ... -
Ultrasound-mediated delivery enhances therapeutic efficacy of MMP sensitive liposomes
Olsman, Marieke; Sereti, Viktoria; Andreassen, Kristine; Snipstad, Linn Sofie; van Wamel, Johanna Elisabeth Theodora; Eliasen, Rasmus; Berg, Sigrid; Urquhart, Andrew J.; Andresen, Thomas L.; Davies, Ruth Catharina de Lange (Peer reviewed; Journal article, 2020)To improve therapeutic efficacy of nanocarrier drug delivery systems, it is essential to improve their uptake and penetration in tumour tissue, enhance cellular uptake and ensure efficient drug release at the tumour site. ... -
Ultrasound-Mediated Delivery of Chemotherapy into the Transgenic Adenocarcinoma of the Mouse Prostate Model
Fagerland, Stein-Martin Tilrum; Berg, Sigrid; Hill, Deborah Katherine; Snipstad, Sofie; Sulheim, Einar; Hyldbakk, Astrid; Kim, Jana; Davies, Catharina de Lange (Peer reviewed; Journal article, 2020)Ultrasound (US) in combination with microbubbles (MB) has had promising results in improving delivery of chemotherapeutic agents. However, most studies are done in immunodeficient mice with xenografted tumors. We used two ...