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BRAF V600E mutation in early-stage multiple myeloma: good response to broad acting drugs and no relation to prognosis
Rustad, Even Holth; Dai, Hong Yan; Hov, Håkon; Coward, Eivind; Beisvag, Vidar; Myklebost, Ola; Hovig, Eivind; Nakken, Sigve; Vodak, Daniel; Meza-Zepeda, Leonardo A.; Sandvik, Arne Kristian; Wader, Karin Fahl; Misund, Kristine; Sundan, Anders; Aarset, Harald; Waage, Anders (Journal article; Peer reviewed, 2015)In this study, we analyzed the prevalence and clone size of BRAF V600E mutation in 209 patients with multiple myeloma and related the results to clinical phenotype, response and survival. Biopsies were screened for BRAF ... -
Contributions of the EMERALD project to assessing and improving microarray data quality
Beisvag, Vidar; Kauffmann, Audrey; Malone, James; Foy, Carole; Salit, Marc; Schimmel, H; Bongcam-Rudloff, Eric; Landegren, Ulf; Parkinson, Helen; Huber, Wolfgang; Brazma, Alvis; Sandvik, Arne Kristian; Kuiper, Martin (Journal article; Peer reviewed, 2011)While minimum information about a microarray experiment (MIAME) standards have helped to increase the value of the microarray data deposited into public databases like ArrayExpress and Gene Expression Omnibus (GEO), limited ... -
Expanding the utilization of formalin-fixed, paraffin-embedded archives: Feasibility of miR-Seq for disease exploration and biomarker development from biopsies with clear cell renal cell Carcinoma
Strauss, Philipp; Marti, Hans-Peter; Beisland, Christian; Scherer, Andreas; Lysne, Vegard; Leh, Sabine Maria; Flatberg, Arnar; Koch, Even Evjen; Beisvag, Vidar; Landolt, Lea Zoe; Skogstrand, Trude; Eikrem, Øystein Solberg (Journal article; Peer reviewed, 2018)Novel predictive tools for clear cell renal cell carcinoma (ccRCC) are urgently needed. MicroRNAs (miRNAs) have been increasingly investigated for their predictive value, and formalin-fixed paraffin-embedded biopsy archives ... -
Expression of Toll-like receptor-3 is enhanced in active inflammatory bowel disease and mediates the excessive release of lipocalin 2
Østvik, Ann Elisabet; Granlund, Atle Van Beelen; Torp, Sverre Helge; Flatberg, Arnar; Beisvag, Vidar; Waldum, Helge; Flo, Trude Helen; Espevik, Terje; Damås, Jan Kristian; Sandvik, Arne Kristian (Journal article; Peer reviewed, 2013)Anti-microbial peptides might influence the pathogenesis and course of inflammatory bowel disease (IBD). We sought to clarify the role of the anti-microbial glycoprotein lipocalin 2 (LCN2) in the colon by determining its ... -
Fine needle aspirates of kidneys: A promising tool for RNA sequencing in native and transplanted kidneys
Eikrem, Øystein Solberg; Walther, Tedd Christian; Flatberg, Arnar; Beisvag, Vidar; Strauss, Philipp; Farstad, Magnus; Beisland, Christian; Koch, Even; Mueller, Thomas F.; Marti, Hans-Peter (Journal article; Peer reviewed, 2018)Background Transcriptome analysis is emerging as emerging as a promising tool to enhance precision of diagnosis and monitoring in solid organ transplantation. Clinical progress has however been hampered by the current ... -
Genome-wide analysis of the oxyntic proliferative isthmus zone reveals ASPM as a possible gastric stem/progenitor cell marker overexpressed in cancer.
Vange, Pål; Bruland, Torunn; Beisvag, Vidar; Erlandsen, Sten Even; Flatberg, Arnar; Doseth, Berit; Sandvik, Arne Kristian; Bakke, Ingunn (Journal article; Peer reviewed, 2015)The oxyntic proliferative isthmus zone contains the main stem/progenitor cells that provide for physiological renewal of the distinct mature cell lineages in the oxyntic epithelium of the stomach. These cells are also ... -
Monitoring multiple myeloma by quantification of recurrent mutations in serum
Rustad, Even Holth; Coward, Eivind; Skytøen, Emilie R; Misund, Kristine; Holien, Toril; Standal, Therese; Børset, Magne; Beisvag, Vidar; Myklebost, Ola; Meza, Leonardo Zepeda; Hong, Yan Dai; Sundan, Anders; Waage, Anders (Journal article; Peer reviewed, 2017)Circulating tumor DNA is a promising biomarker to monitor tumor load and genome alterations. We explored the presence of circulating tumor DNA in multiple myeloma patients and its relation to disease activity during long-term ... -
The cytoprotective protein clusterin is overexpressed in hypergastrinemic rodent models of oxyntic preneoplasia and promotes gastric cancer cell survival
Vange, Pål; Bruland, Torunn; Doseth, Berit; Fossmark, Reidar; Sousa, Mirta; Beisvag, Vidar; Sørdal, Øystein Finset; Qvigstad, Gunnar; Waldum, Helge; Sandvik, Arne Kristian; Bakke, Ingunn (Journal article; Peer reviewed, 2017)The cytoprotective protein clusterin is often dysregulated during tumorigenesis, and in the stomach, upregulation of clusterin marks emergence of the oxyntic atrophy (loss of acid-producing parietal cells)-associated ... -
The duration of gastrin treatment affects global gene expression and molecular responses involved in ER stress and anti-apoptosis
Selvik, Linn-Karina M.; Fjeldbo, Christina Sæten; Flatberg, Arnar; Steigedal, Tonje; Misund, Kristine; Anderssen, Endre; Doseth, Berit; Langaas, Mette; Tripathi, Sushil; Beisvag, Vidar; Lægreid, Astrid; Thommesen, Liv; Bruland, Torunn (Journal article; Peer reviewed, 2013)Background How cells decipher the duration of an external signal into different transcriptional outcomes is poorly understood. The hormone gastrin can promote a variety of cellular responses including proliferation, ... -
Transcriptome sequencing (RNAseq) enables utilization of formalin-fixed, paraffin-embedded biopsies with clear cell renal cell carcinoma for exploration of disease biology and biomarker development
Hjelle, Karin Margrethe; Landolt, Lea Zoe; Leh, Sabine Maria; Marti, Hans-Peter; Beisland, Christian; Scherer, Andreas; Skogstrand, Trude; Beisvag, Vidar; Eikrem, Øystein Solberg; Flatberg, Arnar (Journal article; Peer reviewed, 2016)Formalin-fixed, paraffin-embedded (FFPE) tissues are an underused resource for molecular analyses. This proof of concept study aimed to compare RNAseq results from FFPE biopsies with the corresponding RNAlater® (Qiagen, ... -
Whole Genome Gene Expression Meta-Analysis of Inflammatory Bowel Disease Colon Mucosa Demonstrates Lack of Major Differences between Crohn's Disease and Ulcerative Colitis
Granlund, Atle Van Beelen; Flatberg, Arnar; Østvik, Ann Elisabet; Drozdov, Ignat; Gustafsson, Björn; Kidd, Mark; Beisvag, Vidar; Torp, Sverre Helge; Waldum, Helge; Martinsen, Tom Christian; Damås, Jan Kristian; Espevik, Terje; Sandvik, Arne Kristian (Journal article; Peer reviewed, 2013)Background: In inflammatory bowel disease (IBD), genetic susceptibility together with environmental factors disturbs gut homeostasis producing chronic inflammation. The two main IBD subtypes are Ulcerative colitis (UC) ...