Blar i NTNU Open på forfatter "Beck, Carole"
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Genetic Interaction Between DNA Repair Factors in Lymphocyte Development
Huse, Camilla (Master thesis, 2019)Dobbeltråd-brudd (DSB) på DNA-tråden er den mest cytotoksiske skaden i cellene våre. I løpet av utviklingen av B- og T-celler introduseres DSBs med vilje i løpet av V(D)J rekombinasjonen, og repareres av den ikke-homologe ... -
Mediator of DNA Damage Checkpoint Protein 1 Facilitates V(D)J Recombination in Cells Lacking DNA Repair Factor XLF
Beck, Carole; Castaneda Zegarra, Sergio Miguel; Huse, Camilla; Xing, Mengtan; Oksenych, Valentyn (Journal article; Peer reviewed, 2020)DNA double-strand breaks (DSBs) trigger the Ataxia telangiectasia mutated (ATM)-dependent DNA damage response (DDR), which consists of histone H2AX, MDC1, RNF168, 53BP1, PTIP, RIF1, Rev7, and Shieldin. Early stages of B ... -
Normal development of mice lacking PAXX, the paralogue of XRCC4 and XLF
Gago-Fuentes, Raquel; Xing, Mengtan; Sæterstad, Siri; Sarno, Antonio; Dewan, Alisa Elinsdatter; Beck, Carole; Bradamante, Stefano; Bjørås, Magnar; Oksenych, Valentyn (Journal article; Peer reviewed, 2018)DNA repair consists of several cellular pathways which recognize and repair damaged DNA. The classical nonhomologous DNA end-joining (NHEJ) pathway repairs double-strand breaks in DNA. It is required for maturation of both ... -
Robust DNA repair in PAXX-deficient mammalian cells
Dewan, Alisa Elinsdatter; Xing, Mengtan; Lundbæk, Marie Benner; Gago-Fuentes, Raquel; Beck, Carole; Aas, Per Arne; Liabakk, Nina-Beate; Sæterstad, Siri; Khac Thanh Phong, Chau; Kavli, Bodil Merete; Oksenych, Valentyn (Journal article; Peer reviewed, 2018)To ensure genome stability, mammalian cells employ several DNA repair pathways. Nonhomologous DNA end joining (NHEJ) is the DNA repair process that fixes double-strand breaks throughout the cell cycle. NHEJ is involved in ... -
Role of GCN5 and PCAF in the B Lymphocyte Development
Chau, Khac Thanh Phong (Master thesis, 2018)DNA in our cells is constantly damage by internal and external factors generating DSBs. To maintain genome stability, cells have developed various DNA damage surveillance and repair mechanisms to prevent chromosomal ... -
Role of GCN5 and PCAF in the B Lymphocyte Development
Chau, Khac Thanh Phong (Master thesis, 2018)DNA in our cells is constantly damage by internal and external factors generating DSBs. To maintain genome stability, cells have developed various DNA damage surveillance and repair mechanisms to prevent chromosomal ...