Blar i NTNU Open på forfatter "Bassett, David"
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A correlative spatiotemporal microscale study of calcium phosphate formation and transformation within an alginate hydrogel matrix.
Bassett, David; Ucar, Seniz; Sikorski, Pawel; Andreassen, Jens-Petter; Bjørnøy, Sindre Hove; Strand, Berit Løkensgard (Journal article; Peer reviewed, 2016)The modification of soft hydrogels with hard inorganic components is a method used to form composite materials with application in non-load-bearing bone tissue engineering. The inclusion of an inorganic component may provide ... -
Competitive ligand exchange of crosslinking ions for ionotropic hydrogel formation.
Bassett, David; Håti, Armend Gazmeno; Melø, Thor Bernt; Stokke, Bjørn Torger; Sikorski, Pawel (Journal article; Peer reviewed, 2016)Currently there are limitations to gelation strategies to form ionically crosslinked hydrogels, derived in particular from a lack of control over the release kinetics of crosslinking ions, which severely restrict applications. ... -
Controlled mineralisation and recrystallisation of brushite within alginate hydrogels
Bjørnøy, Sindre Hove; Bassett, David; Ucar, Seniz; Sikorski, Pawel; Andreassen, Jens-Petter (Journal article; Peer reviewed, 2016-02)Due to high solubility and fast resorption behaviour under physiological conditions, brushite (CaHPO4⋅2H2O, calcium monohydrogen phosphate dihydrate, dicalcium phosphate dihydrate) has great potential in bone regeneration ... -
Dissolution of copper mineral phases in biological fluids and the controlled release of copper ions from mineralized alginate hydrogels
Bassett, David; Madzovska, Ivana; Beckwith, Kai Sandvold; Melø, Thor Bernt; Sikorski, Pawel; Obradovic, Bojana (Journal article; Peer reviewed, 2015)Here we investigate the dissolution behaviour of copper minerals contained within biocompatible alginate hydrogels. Copper has a number of biological effects and has most recently been evaluated as an alternative to expensive ... -
Formation of Hydroxyapatite via Transformation of Amorphous Calcium Phosphate in the Presence of Alginate Additives
Ucar, Seniz; Bjørnøy, Sindre Hove; Bassett, David; Strand, Berit Løkensgard; Sikorski, Pawel; Andreassen, Jens-Petter (Journal article; Peer reviewed, 2019)Hydroxyapatite (HA) is the primary mineral of vertebral tooth and bone tissue; thus, it is often incorporated into synthetic composite materials designed for hard tissue engineering applications. Understanding the formation ... -
Gelling kinetics and in situ mineralization of alginate hydrogels: A correlative spatiotemporal characterization toolbox.
Åslund, Andreas; Bassett, David; Ucar, Seniz; Sikorski, Pawel; Andreassen, Jens-Petter; Mandaric, Stefan; Bjørnøy, Sindre Hove; Strand, Berit Løkensgard (Journal article; Peer reviewed, 2016)Due to their large water content and structural similarities to the extracellular matrix, hydrogels are an attractive class of material in the tissue engineering field. Polymers capable of ionotropic gelation are of special ... -
Local structure of Ca2+ alginate hydrogels gelled via competitive ligand exchange and measured by small angle X-ray scattering
Yamamoto, K; Yuguchi, Yoshiaki; Stokke, Bjørn Torger; Sikorski, Pawel; Bassett, David (Journal article; Peer reviewed, 2019)Alginates, being linear anionic co-polymers of 1,4-linked residues β-d-ManA (M) and α-l-GulA (G), are widely applied as hydrogel biomaterials due to their favourable in vivo biocompatibility and convenient ionic crosslinking. ... -
Nucleation and Growth of Brushite in the Presence of Alginate
Ucar, Seniz; Bjørnøy, Sindre Hove; Bassett, David; Strand, Berit Løkensgard; Sikorski, Pawel; Andreassen, Jens-Petter (Journal article, 2015)Biomineral formation in vivo is a complex process regulated by functional molecules. Highlighting the mechanisms underlying biomineralization is necessary for a better understanding of in vivo processes and for enhanced ... -
Transformation of brushite to hydroxyapatite and effects of alginate additives
Ucar, Seniz; Bjørnøy, Sindre Hove; Bassett, David; Strand, Berit Løkensgard; Sikorski, Pawel; Andreassen, Jens-Petter (Journal article; Peer reviewed, 2016)Phase transformations are important processes during mineral formation in both in vivo and in vitro model systems and macromolecules are influential in regulating the mineralization processes. Calcium phosphate mineralized ... -
Versatile, cell and chip friendly method to gel alginate in microfluidic devices
Håti, Armend Gazmeno; Bassett, David; Ribe, Jonas Myren; Sikorski, Pawel; Weitz, David A.; Stokke, Bjørn Torger (Journal article, 2016)Alginate is used extensively in microfluidic devices to produce discrete beads or fibres at the microscale. Such structures may be used to encapsulate sensitive cargoes such as cells and biomolecules. On chip gelation of ...