• Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism 

      Itkonen, Harri; Gorad, Saurabh Sayajirao; Duveau, Damien Y.; Martin, Sara E.S.; Barkovskaya, Anna; Bathen, Tone Frost; Moestue, Siver Andreas; Mills, Ian Geoffrey (Journal article; Peer reviewed, 2016)
      Metabolic networks are highly connected and complex, but a single enzyme, O-GlcNAc transferase (OGT) can sense the availability of metabolites and also modify target proteins. We show that inhibition of OGT activity inhibits ...
    • Metabolic re-wiring of isogenic breast epithelial cell lines following epithelial to mesenchymal transition 

      Haldorsson, Skarphedinn; Rohatgi, Neha; Magnusdottir, Manuela; Choudhary, Kumari; Gudjónsson, Thorarinn; Knutsen, Erik; Barkovskaya, Anna; Hilmarsdòttir, Bylgja; Perander, Maria; Mælandsmo, Gunhild; Gudmundsson, Steinn; Rolfsson, Ottar (Journal article; Peer reviewed, 2017)
      Epithelial to mesenchymal transition (EMT) has implications in tumor progression and metastasis. Metabolic alterations have been described in cancer development but studies focused on the metabolic re-wiring that takes ...
    • Metabolic reprogramming supports the invasive phenotype in malignant melanoma 

      Bettum, Ingrid Johanne; Gorad, Saurabh Sayajirao; Barkovskaya, Anna; Pettersen, Solveig; Moestue, Siver Andreas; Vasiliauskaite, Kotryna; Tenstad, Ellen; Øyjord, Tove Ragnhild; Risa, Øystein; Nygaard, Vigdis; Mælandsmo, Gunhild; Prasmickaite, Lina (Journal article; Peer reviewed, 2015)
      Invasiveness is a hallmark of aggressive cancer like malignant melanoma, and factors involved in acquisition or maintenance of an invasive phenotype are attractive targets for therapy. We investigated melanoma phenotype ...
    • O-GlcNAc Transferase Inhibition Differentially Affects Breast Cancer Subtypes 

      Barkovskaya, Anna; Seip, Kotryna; Hilmarsdòttir, Bylgja; Mælandsmo, Gunhild Mari; Moestue, Siver Andreas; Itkonen, Harri (Journal article; Peer reviewed, 2019)
      Post-translational modification of intracellular proteins with a single N-acetylglucosamine sugar (O-GlcNAcylation) regulates signaling, proliferation, metabolism and protein stability. In breast cancer, expression of the ...
    • Targeted Cancer Therapy: Overcoming Plasticity and Resistance 

      Barkovskaya, Anna (Doctoral theses at NTNU;2019:283, Doctoral thesis, 2019)