Blar i NTNU Open på forfatter "Bakke, Ingunn"
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5-ASA Affects the PPAR-gamma Protein Expression and Chemokine Release in Intestinal Epithelial Cells
Lokøy, Renate (Master thesis, 2024)Bakgrunn: Inflammatorisk tarm sykdom (IBD) er en kronisk immunologisk sykdom som består av ulcerøs kolitt (UC) og Crohn’s sykdom (CD). De karakteriseres av betennelse i fordøyelsessystemet, oftest i tarmene. Hva som ... -
A quantification of epithelial and lamina propria γδ T-cells in microscopic colitis using deep segmentation networks and automated cell classification
Zogby, Khalil (Master thesis, 2024)Introduksjon: γδ T-celler finnes i tykktarmen som intraepiteliale lymfocytter (IEL) og i lamina propria (LP). Deres funksjoner omfatter intestinal immunovervåking og regulering, samt vedlikehold av epitelets integritet. ... -
A study on the variety in expression of PPARγ in the GI-tract
Moldskred, Håvard Helsem (Master thesis, 2024)2.1 Bakgrunn Inflammatorisk tarmsykdom (IBD) er fellesbetegnelsen på de to individuelle sykdommene ulcerøs kolitt (UC) og Crohns sykdom (CD). Nåværende konsensus er at etiologiene deres er likere enn de er ulike. ... -
Code-Free Development and Deployment of Deep Segmentation Models for Digital Pathology
Pettersen, Henrik P Sahlin; Belevich, Ilya; Røyset, Elin Synnøve; Smistad, Erik; Simpson, Melanie Rae; Jokitalo, Eija; Reinertsen, Ingerid; Bakke, Ingunn; Pedersen, André (Peer reviewed; Journal article, 2022)Application of deep learning on histopathological whole slide images (WSIs) holds promise of improving diagnostic efficiency and reproducibility but is largely dependent on the ability to write computer code or purchase ... -
Comprehensive protocols for culturing and molecular biological analysis of IBD patient-derived colon epithelial organoids
Gopalakrishnan, Shreya; Bakke, Ingunn; Hansen, Marianne Dore; Skovdahl, Helene Kolstad; Granlund, Atle van Beelen; Sandvik, Arne Kristian; Bruland, Torunn (Journal article; Peer reviewed, 2023) -
Deep learning-based image analysis reveals significant differences in the number and distribution of mucosal CD3 and γδ T cells between Crohn's disease and ulcerative colitis
Røyset, Elin Synnøve; Pettersen, Henrik Sahlin; Xu, Weili; Larbi, Anis; Sandvik, Arne Kristian; Steigen, Sonja Eriksson; Catalan-Serra, Ignacio; Bakke, Ingunn (Peer reviewed; Journal article, 2022)Colon mucosae of ulcerative colitis (UC) and Crohn's disease (CD) display differences in the number and distribution of immune cells that are difficult to assess by eye. Deep learning-based analysis on whole slide images ... -
Dissecting the roles of ASPM and Clusterin in gastric oxyntic mucosa - from immature stem cells to metaplastic chief cells
Vange, Pål (Doctoral theses at NTNU;2018:289, Doctoral thesis, 2018)Gastric cancer is the third most common cause of cancer-related mortality worldwide. Increased understanding of initiation of gastric carcinogenesis and development of tools that enable early diagnosis are of critical ... -
Effects of Budesonide on the Intestinal Epithelium: Studies using IBD patient-derived Colonoids
Hammarqvist, Emilie Prytz (Master thesis, 2021)Bakgrunn: Tarmepitelcellene er etter hvert anerkjent som en viktig faktor i sykdomsbildet til inflammatoriske tarmsykdom (IBD). Det tradisjonelle anti-inflammatoriske steroid- legemiddelet budesonid er mye brukt i behandling ... -
Effects of Deucravacitinib in Intestinal Epithelial Cells
Cermakova, Romana (Master thesis, 2024)Bakgrunn: Inflammatorisk tarmsykdom (IBD), inkludert Crohns sykdom og ulcerøs kolitt, referer til en gruppe kroniske medisinske lidelser som forårsaker vedvarende betennelse i mage-tarmkanalen. Den eksakte årsaken til IBD ... -
Effects of JAK inhibitor Brepocitinib on Intestinal Epithelial Cells
Myrseth, Marte Gisvold (Master thesis, 2024)Bakgrunn og mål: Inflammatorisk tarmsykdom (IBD) inkluderer en gruppe kroniske inflammatoriske lidelser som påvirker fordøyelseskanalen. Tarmepitelceller spiller en viktig rolle i opprettholdelsen av homeostasen i tarmen ... -
Expression of CCL20 and Its Corresponding Receptor CCR6 Is Enhanced in Active Inflammatory Bowel Disease, and TLR3 Mediates CCL20 Expression in Colonic Epithelial Cells
Skovdahl, Helene Kolstad; Granlund, Atle Van Beelen; Østvik, Ann Elisabet; Bakke, Ingunn; Bruland, Torunn; Torp, Sverre Helge; Damås, Jan Kristian; Sandvik, Arne Kristian (Journal article; Peer reviewed, 2015)Background: The chemokine CCL20 and its receptor CCR6 are putative drug targets in inflammatory bowel disease, and CCL20 is a novel IBD predilection gene. Previous findings on the CCL20 response in these diseases are ... -
Expression of PPARγ in inflammatory bowel disease: a role in regulating colonic inflammation
Eriksen, Kaja Sørgård (Master thesis, 2017)Background: Inflammatory bowel disease (IBD) is a collective term for the two entities, ulcerative colitis (UC) and Crohn’s disease (CD). They are both characterized by a relapsing inflammation causing destruction of the ... -
Gastric Corpus Mucosal Hyperplasia and Neuroendocrine Cell Hyperplasia, but not Spasmolytic Polypeptide-Expressing Metaplasia, Is Prevented by a Gastrin Receptor Antagonist in H+/K+ATPase Beta Subunit Knockout Mice
Aasarød, Kristin Matre; Waldum, Helge; Stunes, Astrid Kamilla; Sandvik, Arne Kristian; Flatberg, Arnar; Mjønes, Patricia; Syversen, Unni; Bakke, Ingunn; Fossmark, Reidar (Journal article; Peer reviewed, 2020)Proton pump inhibitor use is associated with an increased risk of gastric cancer, which may be mediated by hypergastrinemia. Spasmolytic polypeptide-expression metaplasia (SPEM) has been proposed as a precursor of gastric ... -
Genome-wide analysis of the oxyntic proliferative isthmus zone reveals ASPM as a possible gastric stem/progenitor cell marker overexpressed in cancer.
Vange, Pål; Bruland, Torunn; Beisvag, Vidar; Erlandsen, Sten Even; Flatberg, Arnar; Doseth, Berit; Sandvik, Arne Kristian; Bakke, Ingunn (Journal article; Peer reviewed, 2015)The oxyntic proliferative isthmus zone contains the main stem/progenitor cells that provide for physiological renewal of the distinct mature cell lineages in the oxyntic epithelium of the stomach. These cells are also ... -
Intestinal epithelial cells express immunomodulatory ISG15 during active ulcerative colitis and Crohn's disease
Østvik, Ann Elisabet; Svendsen, Tarjei Dahl; Granlund, Atle van Beelen; Doseth, Berit; Skovdahl, Helene Kolstad; Bakke, Ingunn; Thorsvik, Silje; Afroz, Wahida; Walaas, Gunnar Andreas; Mollnes, Tom Eirik; Gustafsson, Björn; Sandvik, Arne Kristian; Bruland, Torunn (Peer reviewed; Journal article, 2020)Background and Aims Intestinal epithelial cells [IECs] secrete cytokines that recruit immune cells to the mucosa and regulate immune responses that drive inflammation in inflammatory bowel disease [IBD]. However, experiments ... -
Mapping anaerobic sludge bed community adaptations to manure supernatant in biogas reactors
Nordgård, Anna Synnøve Røstad; Bergland, Wenche Hennie; Bakke, Rune; Østgaard, Kjetill; Bakke, Ingunn (Journal article; Peer reviewed, 2018)In upflow anaerobic sludge bed (UASB) reactors, biomass present as granules allows for long solids retention time. Here, granules from a process treating pulp and paper industrial wastewater were successfully applied as ... -
Mechanisms and consequences of peroxisome proliferator-induced hyperfunction of the rat gastrinproducing cell
Bakke, Ingunn (Doktoravhandlinger ved NTNU, 1503-8181, Doctoral thesis, 2002)Peroxisome proliferators (PPs) comprise the largest group of non-genotoxic carcinogens and include both synthetic and physiological ligands like hypoliidemic fibrates, anti-diabetic thiazolidinediones (TZD), non-steroidal ... -
Microencapsulation of small intestinal neuroendocrine neoplasm cells for tumor model studies
Rokstad, Anne Mari; Gustafsson, Björn; Espevik, Terje; Bakke, Ingunn; Pfragner, Roswitha; Svejda, Bernhard; Modlin, Irvin M; Kidd, Mark (Journal article; Peer reviewed, 2012)Basic cancer research is dependent on reliable in vitro and in vivo tumor models. The serotonin (5‐HT) producing small intestinal neuroendocrine tumor cell line KRJ‐1 has been used in in vitro proliferation and secretion ... -
Mucosal and faecal neutrophil gelatinase-associated lipocalin as potential biomarkers for collagenous colitis
Bakke, Ingunn; Walaas, Gunnar Andreas; Bruland, Torunn; Røyset, Elin Synnøve; Granlund, Atle van Beelen; Escudero-Hernandez, Celia; Thorsvik, Silje; Münch, Andreas; Sandvik, Arne Kristian; Østvik, Ann Elisabet (Peer reviewed; Journal article, 2021)Background Collagenous colitis (CC) is an inflammatory bowel disease where chronic diarrhoea is the main symptom. Diagnostic markers distinguishing between CC and other causes of chronic diarrhoea remain elusive. This study ... -
NR4A2 Is Regulated by Gastrin and Influences Cellular Responses of Gastric Adenocarcinoma Cells
Misund, Kristine; Selvik, Linn-Karina M.; Rao, Shalini; Nørsett, Kristin Gabestad; Bakke, Ingunn; Sandvik, Arne; Lægreid, Astrid; Bruland, Torunn; Prestvik, Wenche S; Thommesen, Liv (Journal article; Peer reviewed, 2013)