Blar i NTNU Open på forfatter "Børte, Sigrid"
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Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
Liu, Ming; Jiang, Yu; Wedow, Robbee; Li, Yue; Brazel, David M.; Chen, Fang; Datta, Gargi; Davila-Velderrain, Jose; Mitchell, Amy; Skogholt, Anne Heidi; Sivertsen, Børge; Stordal, Eystein; Morken, Gunnar; Kallestad, Håvard; Heuch, Ingrid; Zwart, John-Anker; Fjukstad, Katrine Kveli; Pedersen, Linda Margareth; Johnsen, Marianne Bakke; Skrove, Marit Synnøve; Indredavik, Marit Sæbø; Drange, Ole Kristian; Bjerkeset, Ottar; Børte, Sigrid; Stensland, Synne; Choquet, Hélène; Docherty, Anna R.; Faul, Jessica D.; Foerster, Johanna R.; Fritsche, Lars; Gabrielsen, Maiken Elvestad; Gordon, Scott D.; Haessler, Jeffrey; Hottenga, Jouke-Jan; Huang, Hongyan; Jang, Seon-Kyeong; Jansen, Philip R.; Ling, Yueh; Mägi, Reedik; Matoba, Nana; McMahon, George; Mulas, Antonella; Orrú, Valeria; Palviainen, Teemu; Pandit, Anita; Reginsson, Gunnar W.; Smith, Jennifer A.; Taylor, Amy E.; Turman, Constance; Willemsen, Gonneke; Young, Hannah; Young, Kendra A.; Zajac, Gregory J.M.; Zhao, Wei; Zhou, Wei; Björnsdóttir, Gyda Thora; Boardman, Jason D.; Boehnke, Michael; Boomsma, Dorret I.; Chen, Chu; Davies, Gareth E.; Eaton, Charles B.; Winsvold, Bendik K S; Hveem, Kristian; Vrieze, Scott (Journal article; Peer reviewed, 2019)Tobacco and alcohol use are leading causes of mortality that influence risk for many complex diseases and disorders1. They are heritable2,3 and etiologically related4,5 behaviors that have been resistant to gene discovery ... -
Caesarean section and the association with migraine: a retrospective register-linked HUNT population cohort study
Kristoffersen, Espen Saxhaug; Børte, Sigrid; Hagen, Knut; Zwart, John-Anker; Winsvold, Bendik K S (Peer reviewed; Journal article, 2020)Objectives To evaluate the association between caesarean section and migraine in a population-based register-linked cohort study. Setting Data from the population-based Nord-Trøndelag Health Studies (HUNT2 and HUNT3) ... -
Cluster Headache Genomewide Association Study and Meta-Analysis Identifies Eight Loci and Implicates Smoking as Causal Risk Factor
Winsvold, Bendik Kristoffer Slagsvold; Harder, Aster V. E.; Ran, Caroline; Chalmer, Mona A.; Dalmasso, Maria Carolina; Ferkingstad, Egil; Tripathi, Kumar Parijat; Bacchelli, Elena; Børte, Sigrid; Fourier, Carmen; Petersen, Anja S.; Vijfhuizen, Lisanne S.; Magnusson, Sigurdur H.; O'Connor, Emer; Bjornsdottir, Gyda; Häppölä, Paavo; Wang, Yen-Feng; Callesen, Ida; Kelderman, Tim; Gallardo, Victor J; de Boer, Irene; Olofsgård, Felicia Jennysdotter; Heinze, Katja; Lund, Nunu; Thomas, Laurent Francois; Hsu, Chia-Lin; Pirinen, Matti; Hautakangas, Heidi; Ribasés, Marta; Guerzoni, Simona; Sivakumar, Prasanth; Yip, Janice; Heinze, Axel; Küçükali, Fahri; Ostrowski, Sisse R.; Pedersen, Ole B.; Kristoffersen, Espen Saxhaug; Martinsen, Amy; Artigas, María S.; Lagrata, Susie; Cainazzo, Maria Michela; Adebimpe, Joycee; Quinn, Olivia; Göbel, Carl; Cirkel, Anna; Volk, Alexander E.; Heilmann-Heimbach, Stefanie; Skogholt, Anne Heidi; Gabrielsen, Maiken Elvestad; Wilbrink, Leopoldine A.; Danno, Daisuke; Mehta, Dwij; Guðbjartsson, Daníel F.; Rosendaal, Frits Richard; Willems van Dijk, Ko; Fronczek, Rolf; Wagner, Michael; Scherer, Martin; Göbel, Hartmut; Sleegers, Kristel; Sveinsson, Olafur A.; Pani, Luca; Zoli, Michele; Ramos-Quiroga, Josep A.; Dardiotis, Efthimios; Steinberg, Anna; Riedel-Heller, Steffi; Sjöstrand, Christina; Thorgeirsson, Thorgeir E.; Stefansson, Hreinn; Southgate, Laura; Trembath, Richard C.; Vandrovcova, Jana; Noordam, Raymond; Paemeleire, Koen; Stefansson, Kari; Fann, Cathy Shen-Jang; Waldenlind, Elisabet; Tronvik, Erling Andreas; Jensen, Rigmor H.; Chen, Shih-Pin; Houlden, Henry; Terwindt, Gisela M.; Kubisch, Christian; Maestrini, Elena; Vikelis, Michail; Pozo-Rosich, Patricia; Belin, Andrea C.; Matharu, Manjit; van den Maagdenberg, Arn M.J.M.; Hansen, Thomas; Ramirez, Alfredo; Zwart, John Anker Henrik (Peer reviewed; Journal article, 2023)Objective The objective of this study was to aggregate data for the first genomewide association study meta-analysis of cluster headache, to identify genetic risk variants, and gain biological insights. Methods A ... -
COL11A1 is associated with developmental dysplasia of the hip and secondary osteoarthritis in the HUNT study
Jacobsen, Kaya Kvarme; Børte, Sigrid; Laborie, Lene Bjerke; Kristiansen, Hege; Schäfer, Annette; Gundersen, Trude; Zayats, Tetyana; Winsvold, Bendik Kristoffer Slagsvold; Karen, Rosendahl; Martinsen, Amy; Skogholt, Anne Heidi; Brumpton, Ben Michael; Willer, Cristen J; Fors, Egil Andreas; Kristoffersen, Espen Saxhaug; Heuch, Ingrid; Mundal, Ingunn Pernille; Zwart, John Anker Henrik; Nielsen, Jonas B.; Storheim, Kjersti; Hagen, Knut; Nilsen, Kristian Bernhard; Hveem, Kristian; Fritsche, Lars G; Thomas, Laurent Francois; Pedersen, Linda Margareth; Gabrielsen, Maiken Elvestad; Lie, Marie U.; Stensland, Synne; Zhou, Wei (Peer reviewed; Journal article, 2023)Objective: Developmental dysplasia of the hip (DDH) is a congenital condition affecting 2-3% of all infants. DDH increases the risk of osteoarthritis, is the cause of 30% of all total hip arthroplasties (THAs) in adults ... -
Development and validation of a prediction model for incident hand osteoarthritis in the HUNT study
Johnsen, Marianne Bakke; Magnusson, Karin; Børte, Sigrid; Gabrielsen, Maiken Elvestad; Winsvold, Bendik K S; Skogholt, Anne Heidi; Thomas, Laurent; Storheim, Kjersti; Hveem, Kristian; Zwart, John-Anker (Peer reviewed; Journal article, 2020)Objective To develop and externally validate prediction models for incident hand osteoarthritis (OA) in a large population-based cohort of middle aged and older men and women. Design We included 17,153 men and 18,682 ... -
Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools
Bahrami, Shahram; Hindley, Guy Frederick Lanyon; Winsvold, Bendik K S; O'Connell, Kevin S; Frei, Oleksandr; Shadrin, Alexey; Cheng, Weiqiu; Bettella, Francesco; Rødevand, Linn; Ødegaard, Ketil Joachim; Fan, Chun C; Pirinen, Matti J; Hautakangas, Heidi M; Martinsen, Amy; Skogholt, Anne Heidi; Brumpton, Ben Michael; Willer, Cristen J; Tronvik, Erling Andreas; Kristoffersen, Espen Saxhaug; Zwart, John Anker Henrik; Nielsen, Jonas Bille; Hagen, Knut; Nilsen, Kristian Bernhard; Hveem, Kristian; Stovner, Lars Jacob; Fritsche, Lars; Thomas, Laurent; Pedersen, Linda Margareth; Gabrielsen, Maiken Elvestad; Johnsen, Marianne Bakke; Lie, Marie; Holmen, Oddgeir Lingaas; Børte, Sigrid; Stensland, Synne; Zhou, Wei; Dale, Anders; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Andreassen, Ole (Peer reviewed; Journal article, 2022)Migraine is three times more prevalent in people with bipolar disorder or depression. The relationship between schizophrenia and migraine is less certain although glutamatergic and serotonergic neurotransmission are ... -
Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache
Harder, Aster V.E.; Winsvold, Bendik K S; Noordam, Raymond; Vijfhuizen, Lisanne S.; Børte, Sigrid; Kogelman, Lisette J.A.; de Boer, Irene; Tronvik, Erling Andreas; Rosendaal, Frits; Willems van Dijk, Ko; O'Connor, Emer; Fourier, Carmen; Thomas, Laurent; Kristoffersen, Espen Saxhaug; Fronczek, Rolf; Pozo-Rosich, Patricia; Jensen, Rigmor; Ferrari, Michel D.; Hansen, Thomas; Zwart, John-Anker; Terwindt, Gisela M.; van den Maagdenberg, Arn M.J.M (Peer reviewed; Journal article, 2021)Objective Identifying common genetic variants that confer genetic risk for cluster headache. Methods We conducted a case–control study in the Dutch Leiden University Cluster headache neuro-Analysis program (LUCA) study ... -
Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions
Khoury, Samar; Parisien, Marc; Thompson, Scott J.; Vachon-Presseau, Etienne; Roy, Mathieu; Mitchell, Amy; Winsvold, Bendik K S; Skogholt, Anne Heidi; Brumpton, Ben Michael; Willer, Cristen J.; Fors, Egil Andreas; Heuch, Ingrid; Nielsen, Jonas Bille; Storheim, Kjersti; Hagen, Knut; Nilsen, Kristian Bernhard; Hveem, Kristian; Fritsche, Lars; Thomas, Laurent; Pedersen, Linda Margareth; Gabrielsen, Maiken Elvestad; Johnsen, Marianne Bakke; Lie, Marie; Holmen, Oddgeir; Børte, Sigrid; Stensland, Synne; Zhou, Wei; Mundal, Ingunn Pernille; Zwart, John Anker Henrik; Kania, Artur; Mogil, Jeffrey S.; Diatchenko, Luda (Peer reviewed; Journal article, 2021)Chronic pain is often present at more than one anatomical location, leading to chronic overlapping pain conditions (COPC). Whether COPC represents a distinct pathophysiology from the occurrence of pain at only one site is ... -
Genome-wide association study identifies RNF123 locus as associated with chronic widespread musculoskeletal pain
Rahman, Shafiqur; Winsvold, Bendik K S; Chavez, Sergio; Børte, Sigrid; Tsepilov, Vakov; Sharapov, Sodbo Zh; Aulchenko, Yurii S.; Hagen, Knut; Fors, Egil Andreas; Hveem, Kristian; Zwart, John Anker Henrik; Meurs, Joyce van; Freidin, Maxim B.; Williams, Frances Mk (Peer reviewed; Journal article, 2021)Abstract Background and objectives Chronic widespread musculoskeletal pain (CWP) is a symptom of fibromyalgia and a complex trait with poorly understood pathogenesis. CWP is heritable (48%–54%), but its genetic architecture ... -
Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
Bakker, Mark K.; Spek, Rick A.A. var der; Rheenen, Wouter van; Morel, Sandrine; Bourcier, Romain; Hostettler, Isabel C.; Varinder, S. Alg; Eijk, Kristel R. van; Koido, Masaru; Akiyama, Masato; Terao, Chikashi; Matsuda, Koichi; Walters, Robin G.; Lin, Kuang; Li, Liming; Millwood, Iona Y.; Chen, Zhengming; Rouleau, Guy A.; Zhou, Sirui; Rannikmae, Kristiina; Sudlow, Cathie L.M.; Houlden, Henry; Berg, Leonard H. van den; Dina, Christian; Naggara, Olivier; Gentric, Jean-Christophe; Shotar, Eimad; Eugène, François; Desal, Hubert; Winsvold, Bendik K S; Børte, Sigrid; Johnsen, Marianne Bakke; Brumpton, Ben Michael; Sandvei, Marie Søfteland; Willer, Cristen J.; Hveem, Kristian; Zwart, John-Anker; Verschuren, W.M. Monique; Friedrich, Christoph M.; Hirsch, Sven; Schilling, Sabine; Dauvillier, Jérôme; Martin, Olivier; Jones, Gregory T.; Bown, Matthew J.; Ko, Nerissa U.; Kim, Helen; Coleman, Jonathan R. I.; Breen, Gerome; Zaroff, Jonathan G. (Peer reviewed; Journal article, 2020)Rupture of an intracranial aneurysm leads to subarachnoid hemorrhage, a severe type of stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we performed a cross-ancestry, genome-wide ... -
A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease
Wightman, Douglas P.; Jansen, Iris E.; Savage, Jeanne E.; Shadrin, Alexey; Bahrami, Shahram; Holland, Dominic; Rongve, Arvid; Børte, Sigrid; Winsvold, Bendik K S; Drange, Ole Kristian; Martinsen, Amy E.; Skogholt, Anne Heidi; Willer, Cristen; Bråthen, Geir; Bosnes, Ingunn; Nielsen, Jonas Bille; Fritsche, Lars; Thomas, Laurent; Pedersen, Linda Margareth; Gabrielsen, Maiken Elvestad; Johnsen, Marianne Bakke; Meisingset, Tore Wergeland; Zhou, Wei; Proitsi, Petroula; Hodges, Angela; Dobson, Richard; Velayudhan, Latha; Sealock, Julia; Davis, Lea K.; Pedersen, Nancy L.; Reynolds, Chandra A.; Karlsson, Ida K.; Magnusson, Sigurdur; Stefansson, Hreinn; Thordardottir, Steinunn; Jónsson, Pálmi V.; Snædal, Jon; Zettergren, Anna; Skoog, Ingmar; Kern, Silke; Waern, Margda; Zetterberg, Henrik; Blennow, Kaj; Stordal, Eystein; Hveem, Kristian; Zwart, John Anker Henrik; Athanasiu, Lavinia; Selnes, Per; Saltvedt, Ingvild; Sando, Sigrid Botne; Ulstein, Ingun; Djurovic, Srdjan; Fladby, Tormod; Aarsland, Dag; Selbæk, Geir; Ripke, Stephan; Stefánsson, Kári; Andreassen, Ole; Posthuma, Danielle (Journal article; Peer reviewed, 2021)Late-onset Alzheimer’s disease is a prevalent age-related polygenic disease that accounts for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying Alzheimer’s disease have been identified. ... -
Migraine, obesity and body fat distribution - a population-based study
Kristoffersen, Espen Saxhaug; Børte, Sigrid; Hagen, Knut; Zwart, John-Anker; Winsvold, Bendik K S (Peer reviewed; Journal article, 2020)Background: Obesity has been linked to an increased prevalence of migraine, and to increased migraine attack frequency, but several questions are left unanswered by previous studies. We examined the relationship between ... -
Mitochondrial genome-wide association study of migraine – the HUNT Study
Børte, Sigrid; Zwart, John-Anker; Skogholt, Anne Heidi; Gabrielsen, Maiken Elvestad; Thomas, Laurent; Fritsche, Lars G; Surakke, Ida; Nielsen, Jonas B.; Zhou, Wei; Wolford, Brooke; Vigeland, Magnus Dehli; Hagen, Knut; Kristoffersen, Espen Saxhaug; Nyholt, Dale R; Chasman, Daniel I; Brumpton, Ben Michael; Willer, Christen; Winsvold, Bendik K S (Peer reviewed; Journal article, 2020)Background Variation in mitochondrial DNA (mtDNA) has been indicated in migraine pathogenesis, but genetic studies to date have focused on candidate variants, with sparse findings. We aimed to perform the first mitochondrial ... -
Parental migraine in relation to migraine in offspring: Family linkage analyses from the HUNT Study
Børte, Sigrid; Zwart, John-Anker; Stensland, Synne; Hagen, Knut; Winsvold, Bendik K S (Journal article; Peer reviewed, 2019)Background Migraine is known to run in families. While some clinical studies have indicated that migraine is disproportionally transmitted through the maternal line, this has not been examined in a population-based ... -
Stroke genetics informs drug discovery and risk prediction across ancestries
Mishra, Aniket; Malik, Rainer; Hachiya, Tsuyoshi; Jürgenson, Tuuli; Namba, Shinichi; Posner, Daniel C.; Kamanu, Frederick K.; Koido, Masaru; Le Grand, Quentin; Shi, Mingyang; He, Yunye; Georgakis, Marios K.; Caro, Ilana; Krebs, Kristine; Liaw, Yi-Ching; Vaura, Felix C.; Lin, Kuang; Winsvold, Bendik K S; Srinivasasainagendra, Vinodh; Parodi, Livia; Bae, Hee-Joon; Chauhan, Ganesh; Tomppo, Liisa; Akinyemi, Rufus; Roshchupkin, Gennady V.; Habib, Naomi; Jee, Yon Ho; Thomassen, Jesper Qvist; Abedi, Vida; Cárcel-Márquez, Jara; Nygaard, Marianne; Leonard, Hampton L.; Yang, Chaojie; Yonova-Doing, Ekaterina; Knol, Maria J.; Lewis, Adam J.; Judy, Renae L.; Ago, Tetsuro; Amouyel, Philippe; Armstrong, Nicole D.; Bakker, Mark K.; Bartz, Traci M.; Bennett, David A.; Bis, Joshua C.; Bordes, Constance; Børte, Sigrid; Cain, Anael; Ridker, Paul M.; Cho, Kelly; Chen, Zhengming; Cruchaga, Carlos; Cole, John W.; de Jager, Phil L.; de Cid, Rafael; Endres, Matthias; Ferreira, Leslie E.; Geerlings, Mirjam I.; Gasca, Natalie C.; Gudnason, Vilmundur; Hata, Jun; He, Jing; Heath, Alicia K.; Ho, Yuk-Lam; Havulinna, Aki S.; Hopewell, Jemma C.; Hyacinth, Hyacinth I.; Inouye, Michael; Jacob, Mina A.; Jeon, Christina E.; Jern, Christina; Kamouchi, Masahiro; Keene, Keith L.; Kitazono, Takanari; Kittner, Steven J.; Konuma, Takahiro; Kumar, Amit; Lacaze, Paul; Launer, Lenore J.; Lee, Keon-Joo; Lepik, Kaido; Li, Jiang; Li, Liming; Manichaikul, Ani; Markus, Hugh S.; Marston, Nicholas A.; Meitinger, Thomas; Mitchell, Braxton D.; Montellano, Felipe A.; Morisaki, Takayuki; Mosley, Thomas H.; Nalls, Mike A.; Nordestgaard, Børge G; O'Donnell, Martin J.; Okada, Yukinori; Onland-Moret, N Charlotte; Ovbiagele, Bruce; Peters, Annette; Psaty, Bruce M.; Rich, Stephen S.; Rosand, Jonathan; Sabatine, Marc S.; Sacco, Ralph L.; Saleheen, Danish; Sandset, Else Charlotte; Salomaa, Veikko; Sargurupremraj, Muralidharan; Sasaki, Makoto; Satizabal, Claudia L.; Schmidt, Carsten O.; Shimizu, Atsushi; Smith, Nicholas L.; Sloane, Kelly L.; Sutoh, Yoichi; Sun, Yan V.; Tanno, Kozo; Tiedt, Steffen; Tatlisumak, Turgut; Torres-Aguila, Nuria P.; Tiwari, Hemant K.; Trégouët, David-Alexandre; Trompet, Stella; Tuladhar, Anil Man; Tybjærg-Hansen, Anne; van Vugt, Marion; Vibo, Riina; Verma, Shefali S.; Wiggins, Kerri L.; Wennberg, Patrik; Woo, Daniel; Wilson, Peter W F; Xu, Huichun; Yang, Qiong; Yoon, Kyungheon; Millwood, Iona Y.; Gieger, Christian; Ninomiya, Toshiharu; Grabe, Hans J.; Jukema, J Wouter; Rissanen, Ina L.; Strbian, Daniel; Kim, Young Jin; Chen, Pei-Hsin; Mayerhofer, Ernst; Howson, Joanna M M; Irvin, Marguerite R.; Adams, Hieab; Wassertheil-Smoller, Sylvia; Christensen, Kaare; Ikram, Mohammad A.; Rundek, Tatjana; Worrall, Bradford B.; Lathrop, G Mark; Riaz, Moeen; Simonsick, Eleanor M.; Kõrv, Janika; França, Paulo H C; Zand, Ramin; Prasad, Kameshwar; Frikke-Schmidt, Ruth; de Leeuw, Frank-Erik; Liman, Thomas; Haeusler, Karl Georg; Ruigrok, Ynte M.; Heuschmann, Peter Ulrich; Longstreth, W.T.; Jung, Keum Ji; Bastarache, Lisa; Paré, Guillaume; Damrauer, Scott M.; Chasman, Daniel I.; Rotter, Jerome I.; Anderson, Christopher D.; Zwart, John Anker Henrik; Niiranen, Teemu J.; Fornage, Myriam; Liaw, Yung-Po; Seshadri, Sudha; Fernández-Cadenas, Israel; Walters, Robin G.; Ruff, Christian T.; Owolabi, Mayowa O.; Huffman, Jennifer E.; Milani, Lili; Kamatani, Yoichiro; Dichgans, Martin; Debette, Stephanie (Peer reviewed; Journal article, 2022)Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of ... -
The causal role of smoking on the risk of headache. A Mendelian randomization analysis in the HUNT Study
Johnsen, Marianne Bakke; Winsvold, Bendik K S; Børte, Sigrid; Vie, Gunnhild Åberge; Pedersen, Linda Margareth; Storheim, Kjersti; Skorpen, Frank; Hagen, Knut; Bjørngaard, Johan Håkon; Åsvold, Bjørn Olav; Zwart, John-Anker (Journal article; Peer reviewed, 2018)Background and purpose Headache has been associated with various lifestyle and psychosocial factors, one of which is smoking. The aim of the present study was to investigate whether the association between smoking intensity ...