Browsing NTNU Open by Author "Børset, Magne"
Now showing items 1-20 of 32
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Analysis of Intra-Tumoral Macrophages and T Cells in Non-Small Cell Lung Cancer (NSCLC) Indicates a Role for Immune Checkpoint and CD200-CD200R Interactions
Tøndell, Anders; Subbannayya, Yashwanth; Wahl, Sissel Gyrid Freim; Flatberg, Arnar; Sørhaug, Sveinung; Børset, Magne; Haug, Markus (Peer reviewed; Journal article, 2021)Lung cancer is the leading cause of cancer-related death worldwide, accounting for nearly one-fifth of all cancer-related deaths. Immunotherapy with immune checkpoint inhibitors has become one of the most promising approaches ... -
Bronchoalveolar lavage fluid IFN- γ + Th17 cells and regulatory T cells in pulmonary sarcoidosis
Tøndell, Anders; Moen, Torolf; Børset, Magne; Salvesen, Øyvind; Rø, Anne Dorthea; Sue-Chu, Malcolm (Journal article; Peer reviewed, 2014)In sarcoidosis, increased Th17 cell fractions have been reported in bronchoalveolar lavage fluid, and elevated numbers of Th17 cells producing IFN-𝛾 have been observed in peripheral blood. The balance between Th1, Th17, ... -
Bystander memory T cells and IMiD/checkpoint therapy in multiple myeloma: A dangerous tango?
Sponaas, Anne-Marit; Waage, Anders; Vandsemb, Esten; Misund, Kristine; Børset, Magne; Sundan, Anders; Slørdahl, Tobias Schmidt; Standal, Therese (Peer reviewed; Journal article, 2021)In this review article we discuss the role of the memory T cells in multiple myeloma (MM) and how they may influence immune responses in patients that received immunomodulating drugs and check point therapy -
Checkpoint Inhibition in Multiple Myeloma
Yang, Rui (Doctoral theses at NTNU;2019:107, Doctoral thesis, 2019) -
Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade
Yang, Rui; Elsaadi, Samah; Misund, Kristine; Abdollahi, Pegah; Vandsemb, Esten; Moen, Siv Helen; Kusnierczyk, Anna; Slupphaug, Geir; Standal, Therese; Waage, Anders; Slørdahl, Tobias Schmidt; Rø, Torstein Baade; Rustad, Even Holth; Sundan, Anders; Hay, Carl; Cooper, Zachary; Schuller, Alwin G.; Woessner, Richard; Borodowski, Alexandra; Menu, Eline; Børset, Magne; Sponaas, Anne-Marit (Peer reviewed; Journal article, 2020)Background PD1/PDL1-directed therapies have been unsuccessful for multiple myeloma (MM), an incurable cancer of plasma cells in the bone marrow (BM). Therefore, other immune checkpoints such as extracellular adenosine and ... -
Ectonucleotidase CD39 and Checkpoint Signalling Receptor Programmed Death 1 are Highly Elevated in Intratumoral Immune Cells in Non–small-cell Lung Cancer
Tøndell, Anders; Wahl, Sissel Gyrid Freim; Sponaas, Anne-Marit; Sørhaug, Sveinung; Børset, Magne; Haug, Markus (Journal article; Peer reviewed, 2019)Lung cancer is the leading cause of cancer death in both sexes worldwide and has a predicted 5-year survival rate of <20%. Immunotherapy targeting immune checkpoints such as the programmed death 1 (PD-1) signaling pathway ... -
Erythropoietin (EPO)-receptor signaling induces cell death of primary myeloma cells in vitro
Våtsveen, Thea Kristin; Sponaas, Anne Marit; Tian, Erming; Zhang, Qing; Misund, Kristine; Sundan, Anders; Børset, Magne; Waage, Anders; Brede, Gaute (Journal article; Peer reviewed, 2016)Background: Multiple myeloma is an incurable complex disease characterized by clonal proliferation of malignant plasma cells in a hypoxic bone marrow environment. Hypoxia-dependent erythropoietin (EPO)-receptor (EPOR) ... -
Highly expressed genes in multiple myeloma cells – what can they tell us about the disease?
Børset, Magne; Elsaadi, Samah; Vandsemb, Esten Nymoen; Hess, Eli Svorkdal; Steiro, Ida Johnsen; Cócera Fernández, Miguel; Sponaas, Anne-Marit; Abdollahi, Pegah (Peer reviewed; Journal article, 2022)Cancer cells can convert proto-oncoproteins into oncoproteins by increasing the expression of genes that are oncogenic when expressed at high levels. Such genes can promote oncogenesis without being mutated. To find ... -
Identification of the source of elevated hepatocyte growth factor levels in multiple myeloma patients
Rampa, Christoph Samuel; Tian, Erming; Våtsveen, Thea Kristin; Buene, Glenn; Slørdahl, Tobias Schmidt; Børset, Magne; Waage, Anders; Sundan, Anders (Journal article; Peer reviewed, 2014)Background Hepatocyte growth factor (HGF) is a pleiotropic cytokine which can lead to cancer cell proliferation, migration and metastasis. In multiple myeloma (MM) patients it is an abundant component of the bone marrow. ... -
Inhibition of Cytosolic Phospholipase A2α Induces Apoptosis in Multiple Myeloma Cells
Mahammad, Nur; Ashcroft, Felicity; Feuerherm, Astrid Jullumstrø; Elsaadi, Samah; Vandsemb, Esten Nymoen; Børset, Magne; Johansen, Berit (Peer reviewed; Journal article, 2021)Cytosolic phospholipase A2α (cPLA2α) is the rate-limiting enzyme in releasing arachidonic acid and biosynthesis of its derivative eicosanoids. Thus, the catalytic activity of cPLA2α plays an important role in cellular ... -
Investigating the Role of PRL-3 and Targeting PHGDH in Multiple Myeloma
Elsaadi, Samah (Doctoral theses at NTNU;2020:378, Doctoral thesis, 2020)Myelomatose er en hematologisk kreftsykdom som skyldes klonal ekspansjon av plasmaceller som infiltrerer beinmargen. Til tross for fremskritt innen behandlingen av myelomatose, er sykdommen fortsatt uhelbredelig. Artiklene ... -
Markers of endothelial glycocalyx dysfunction in Clarkson disease
Xie, Zhihui; Børset, Magne; Sveen, Kjell; Bøe, Ole Wilhelm; Chan, Eunice C.; Lack, Justin B.; Hornick, Katherine M.; Verlicchi, Franco; Eisch, A. Robin; Melchio, Remo; Dudek, Arkadiusz Z.; Druey, Kirk M. (Peer reviewed; Journal article, 2022)Background Clarkson disease (monoclonal gammopathy-associated idiopathic systemic capillary leak syndrome, ISCLS) is a rare idiopathic condition marked by transient, relapsing-remitting episodes of systemic microvascular ... -
Monitoring multiple myeloma by quantification of recurrent mutations in serum
Rustad, Even Holth; Coward, Eivind; Skytøen, Emilie R; Misund, Kristine; Holien, Toril; Standal, Therese; Børset, Magne; Beisvag, Vidar; Myklebost, Ola; Meza, Leonardo Zepeda; Hong, Yan Dai; Sundan, Anders; Waage, Anders (Journal article; Peer reviewed, 2017)Circulating tumor DNA is a promising biomarker to monitor tumor load and genome alterations. We explored the presence of circulating tumor DNA in multiple myeloma patients and its relation to disease activity during long-term ... -
MYC amplifications in myeloma cell lines; correlation with MYC-inhibitor efficacy
Holien, Toril; Misund, Kristine; Olsen, Oddrun Elise; Baranowska, Katarzyna Anna; Buene, Glenn; Børset, Magne; Waage, Anders; Sundan, Anders (Journal article; Peer reviewed, 2015)In multiple myeloma, elevated MYC expression is related to disease initiation and progression. We found that in myeloma cell lines, MYC gene amplifications were common and correlated with MYC mRNA and protein. In primary ... -
On the role of phosphatase of regenerating liver (PRL-) 3 in cell signaling and metabolism in multiple myeloma
Vandsemb, Esten N. (Doctoral theses at NTNU;2021:275, Doctoral thesis, 2021) -
Phosphatase of regenerating liver 3 (PRL-3) is overexpressed in human prostate cancer tissue and promotes growth and migration
Vandsemb, Esten Nymoen; Bertilsson, Helena; Abdollahi, Pegah; Størkersen, Øystein; Våtsveen, Thea Kristin; Rye, Morten Beck; Rø, Torstein Baade; Børset, Magne; Slørdahl, Tobias Schmidt (Journal article; Peer reviewed, 2016)Background: PRL-3 is a phosphatase implicated in oncogenesis in multiple cancers. In some cancers, notably carcinomas, PRL-3 is also associated with inferior prognosis and increased metastatic potential. In this study we ... -
Phosphatase of regenerating liver-3 (PRL-3) is overexpressed in classical Hodgkin lymphoma and promotes survival and migration
Hjort, Magnus Aasved; Hov, Håkon; Abdollahi, Pegah; Vandsemb, Esten; Fagerli, Unn-Merete; Lund, Bendik; Slørdahl, Tobias Schmidt; Børset, Magne; Rø, Torstein Baade (Journal article; Peer reviewed, 2018)Background Phosphatase of regenerating liver-3 (PRL-3) is implicated in oncogenesis of hematological and solid cancers. PRL-3 expression increases metastatic potential, invasiveness and is associated with poor prognosis. ... -
Phosphatase of regenerating liver-3 as a target for treatment of B cell malignancies
Hjort, Magnus Aassved (Doctoral theses at NTNU;2018:241, Doctoral thesis, 2018)PRL-3 som et angrepsmål i behandlingen av B-cellekreft Akutt lymfatisk leukemi (ALL), Hodgkin lymfom (HL) og myelomatose er kreftsykdommer som oppstår fra B-lymfocytter. Disse cellene er en del av kroppens immunforsvar. ... -
Phosphatase of regenerating liver-3 is expressed in acute lymphoblastic leukemia and mediates leukemic cell adhesion, migration and drug resistance
Hjort, Magnus Aassved; Abdollahi, Pegah; Vandsemb, Esten Nymoen; Fenstad, Mona H.; Lund, Bendik; Slørdahl, Tobias Schmidt; Børset, Magne; Rø, Torstein Baade (Journal article; Peer reviewed, 2017)Phosphatase of regenerating liver-3 (PRL-3/PTP4A3) is upregulated in multiple cancers, including BCR-ABL1- and ETV6-RUNX-positive acute lymphoblastic leukemia (ALL). With this study, we aim to characterize the biological ... -
Phosphatase of Regenerating Liver-3 Regulates Cancer Cell Metabolism in Multiple Myeloma
Abdollahi, Pegah; Vandsemb, Esten; Elsaadi, Samah; Røst, Lisa Marie; Yang, Rui; Hjort, Magnus Aassved; Andreassen, Trygve; Misund, Kristine; Slørdahl, Tobias Schmidt; Rø, Torstein Baade; Sponaas, Anne-Marit; Moestue, Siver Andreas; Bruheim, Per; Børset, Magne (Peer reviewed; Journal article, 2021)Cancer cells often depend on microenvironment signals from molecules such as cytokines for proliferation and metabolic adaptations. PRL‐3, a cytokine‐induced oncogenic phosphatase, is highly expressed in multiple myeloma ...