• E-cadherin cleavage by MT2-MMP regulates apical junctional signaling and epithelial homeostasis in the intestine 

      Gómez-Escudero, Jesús; Moreno, Vanessa; Martín-Alonso, Mara; Hernández de Riquer, M. Victoria; Feinberg, Tamar; Colmenar, Ángel; Calvo, Enrique; Camafeita, Emilio; Martínez, Fernando; J. Weiss, Stephen; Arroyo, Alicia G.; J. Oudhoff, Menno (Journal article; Peer reviewed, 2017)
      Cadherin-based intercellular adhesions are essential players in epithelial homeostasis, but their dynamic regulation during tissue morphogenesis and remodeling remain largely undefined. Herein, we characterize an unexpected ...
    • Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage 

      Alonso, Mara Martin; Iqbal, Sharif; Vornewald, Pia; Lindholm, Håvard Takle; Damen, Mirjam J.; Martínez, Fernando; Hoel, Sigrid; Sanchez, Alberto Diez; Altelaar, Maarten; Katajisto, Pekka; Arroyo, Alicia G.; Oudhoff, Menno (Peer reviewed; Journal article, 2021)
      Smooth muscle is an essential component of the intestine, both to maintain its structure and produce peristaltic and segmentation movements. However, very little is known about other putative roles that smooth muscle cells ...