• Cholesterol synthesis pathway genes in prostate cancer are transcriptionally downregulated when tissue confounding is minimized 

      Rye, Morten Beck; Bertilsson, Helena; Andersen, Maria Karoline; Rise, Kjersti; Bathen, Tone Frost; Drabløs, Finn; Tessem, May-Britt (Journal article; Peer reviewed, 2018)
      Background The relationship between cholesterol and prostate cancer has been extensively studied for decades, where high levels of cellular cholesterol are generally associated with cancer progression and less favorable ...
    • Integrative metabolic and transcriptomic profiling of prostate cancer tissue containing reactive stroma 

      Andersen, Maria Karoline; Rise, Kjersti; Giskeødegård, Guro F.; Richardsen, Elin; Bertilsson, Helena; Størkersen, Øystein; Bathen, Tone Frost; Rye, Morten Beck; Tessem, May-Britt (Journal article; Peer reviewed, 2018)
      Reactive stroma is a tissue feature commonly observed in the tumor microenvironment of prostate cancer and has previously been associated with more aggressive tumors. The aim of this study was to detect differentially ...
    • Metabolic alterations in tissues and biofluids of patients with prostate cancer 

      Andersen, Maria Karoline; Giskeødegård, Guro F.; Tessem, May-Britt (Peer reviewed; Journal article, 2020)
      Altered metabolism is one of the key molecular characteristics of prostate cancer (PCa) development, and a number of studies have searched for metabolic biomarkers in patient-derived samples. Reported metabolic changes in ...
    • NMR-Based Prostate Cancer Metabolomics 

      Euceda, Leslie R.; Andersen, Maria Karoline; Tessem, May-Britt; Moestue, Siver Andreas; Grinde, Maria Tunset; Bathen, Tone Frost (Journal article; Peer reviewed, 2018)
      Prostate cancer is the second most common malignancy, and the fifth leading cause of cancer-related death among men, worldwide. A major unsolved clinical challenge in prostate cancer is the ability to accurately distinguish ...
    • An optimized MALDI MSI protocol for spatial detection of tryptic peptides in fresh frozen prostate tissue 

      Høiem, Therese Stork; Andersen, Maria Karoline; Martin-Lorenzo, Marta; Longuespée, Rémi; Claes, Britt S.R.; Nordborg, Anna; Dewez, Frédéric; Balluff, Benjamin; Giampà , Marco; Sharma, Animesh; Hagen, Lars; Heeren, Ron M.A.; Bathen, Tone Frost; Giskeødegård, Guro F.; Krossa, Sebastian; Tessem, May-Britt (Peer reviewed; Journal article, 2022)
      MALDI MS imaging (MSI) is a powerful analytical tool for spatial peptide detection in heterogeneous tissues. Proper sample preparation is crucial to achieve high quality, reproducible measurements. Here we developed an ...
    • Reproducible lipid alterations in patient-derived breast cancer xenograft FFPE tissue identified with MALDI MSI for pre-clinical and clinical application 

      Denti, Vanna; Andersen, Maria Karoline; Smith, Andrew; Bofin, Anna M.; Nordborg, Anna; Magni, Fulvio; Moestue, Siver Andreas; Giampà, Marco (Peer reviewed; Journal article, 2021)
      The association between lipid metabolism and long-term outcomes is relevant for tumor diagnosis and therapy. Archival material such as formalin-fixed and paraffin embedded (FFPE) tissues is a highly valuable resource for ...
    • SFRP4 gene expression is increased in aggressive prostate cancer 

      Sandsmark, Elise; Andersen, Maria Karoline; Bofin, Anna M.; Bertilsson, Helena; Drabløs, Finn; Bathen, Tone Frost; Rye, Morten Beck; Tessem, May-Britt (Journal article; Peer reviewed, 2017)
      Increased knowledge of the molecular differences between indolent and aggressive prostate cancer is needed for improved risk stratification and treatment selection. Secreted frizzled-related protein 4 (SFRP4) is a modulator ...
    • A simple preparation protocol for shipping and storage of tissue sections for laser ablation-inductively coupled plasma-mass spectrometry imaging 

      Buchholz, Rebecca; Krossa, Sebastian; Andersen, Maria Karoline; Holtkamp, Michael; Sperling, Michael; Karst, Uwe; Tessem, May-Britt (Peer reviewed; Journal article, 2022)
      A rapid and cost-efficient tissue preparation protocol for laser ablation-inductively coupled plasma-mass spectrometry imaging (LA–ICP–MSI) has been developed within this study as an alternative to the current gold standard ...
    • Simultaneous Detection of Zinc and Its Pathway Metabolites Using MALDI MS Imaging of Prostate Tissue 

      Andersen, Maria Karoline; Krossa, Sebastian; Høiem, Therese Stork; Buchholz, Rebecca; Claes, Britt S.R.; Balluff, Benjamin; Ellis, Shane; Richardsen, Elin; Bertilsson, Helena; Heeren, Ron M.A.; Bathen, Tone Frost; Karst, Uwe; Giskeødegård, Guro F.; Tessem, May-Britt (Journal article; Peer reviewed, 2020)
      Levels of zinc, along with its mechanistically related metabolites citrateand aspartate, are widely reported as reduced in prostate cancer compared to healthytissue and are therefore pointed out as potential cancer biomarkers. ...
    • Spatial differentiation of metabolism in prostate cancer tissue by MALDI-TOF MSI 

      Andersen, Maria Karoline; Høiem, Therese Stork; Claes, Britt S.R.; Balluff, Benjamin; Marta, Martin-Lorenzo; Richardsen, Elin; Krossa, Sebastian; Bertilsson, Helena; Heeren, Ron M.A.; Rye, Morten Beck; Giskeødegård, Guro F.; Bathen, Tone Frost; Tessem, May-Britt (Peer reviewed; Journal article, 2021)
      Background Prostate cancer tissues are inherently heterogeneous, which presents a challenge for metabolic profiling using traditional bulk analysis methods that produce an averaged profile. The aim of this study was ...