• Ancient genomes from Iceland reveal the making of a human population 

      Ebenesersdóttir, Sigríður Sunna; Sandoval-Velasco, Marcela; Gunnarsdóttir, Ellen D.; Jagadeesan, Anuradha; Guðmundsdóttir, Valdís B.; Thordardóttir, Elísabet L.; Einarsdóttir, Margrét S.; Moore, Kristjan H. S.; Sigurðsson, Ásgeir; Magnúsdóttir, Droplaug N.; Jónsson, Hákon; Snorradóttir, Steinunn; Hovig, Eivind; Møller, Pål; Kockum, Ingrid; Olsson, Tomas; Alfredsson, Lars; Hansen, Thomas F.; Werge, Thomas; Cavalleri, Gianpiero L.; Gilbert, Edmund; Lalueza-Fox, Carles; Walser III, Joe W.; Kristjánsdóttir, Steinunn; Gopalakrishnan, Shyam; Arnadottir, Lilja; Magnússon, Ólafur Þ.; Gilbert, Marcus Thomas Pius; Stefánsson, Kári; Helgason, Agnar (Journal article; Peer reviewed, 2018)
      Opportunities to directly study the founding of a human population and its subsequent evolutionary history are rare. Using genome sequence data from 27 ancient Icelanders, we demonstrate that they are a combination of ...
    • The genetic history of Scandinavia from the Roman Iron Age to the present 

      Rodriguez-Varela, Ricardo; Moore, Kristjan H.S.; Ebenesersdottir, Sunna; Kilinc, Gulsah; Kjellström, Anna; Papmehl-Dufay, Ludvig; Alfsdotter, Clara; Berglund, Birgitta; Alrawi, Loey; Kashuba, Natlija; Sobrado, Veronica; Lagerholm, Vendela Kempe; Gilbert, Edmund; Cavalleri, Gianpiero L.; Hovig, Eivind; Kockum, Ingrid; Olsson, Tomas; Alfredsson, Lars; Hansen, Thomas F.; Werge, Thomas; Munters, Arielle R.; Bernhardsson, Carolina; Skar, Birgitte; Christophersen, Axel; Turner-Walker, Gordon; Gopalakrishnan, Shyam; Daskalaki, Evangelia; Omrak, Ayca; Perez-Ramallo, Patxi; Skoglund, Pontus; Girdland-Flink, Linus; Gunnarsson, Fredrik; Hedenstierna-Jonson, Charlotte; Gilbert, Marcus Thomas Pius; Lidén, Kerstin; Jakobsson, Mattias; Einarsson, Lars Petter; Victor, Helena; Krzewinska, Maja; Zachrisson, Torun; Storå, Jan; Stefánsson, Kári; Helgason, Agnar; Götherström, Anders (Peer reviewed; Journal article, 2023)
      We investigate a 2,000-year genetic transect through Scandinavia spanning the Iron Age to the present, based on 48 new and 249 published ancient genomes and genotypes from 16,638 modern individuals. We find regional variation ...
    • GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors 

      Docherty, Anna R.; Mullins, Niamh; Ashley-Koch, Allison E.; Qin, Xuejun; Coleman, Jonathan R.I.; Shabalin, Andrey; Kang, JooEun; Murnyak, Balasz; Wendt, Frank; Adams, Mark; Campos, Adrian I.; DiBlasi, Emily; Fullerton, Janice M.; Kranzler, Henry R.; Bakian, Amanda V.; Monson, Eric T.; Rentería, Miguel E.; Walss-Bass, Consuelo; Andreassen, Ole; Behera, Chittaranjan; Bulik, Cynthia M.; Edenberg, Howard J.; Adolfsson, Rolf; Agartz, Ingrid; Alda, Martin; Alfredsson, Lars; Appadurai, Vivek; Artigas, María Soler; Djurovic, Srdjan; Foo, Jerome C.; Forstner, Andreas J.; Frye, Mark; Gatt, Justine; Melle, Ingrid; Mitchell, Philip B.; Molina, Esther; Morken, Gunnar; Smeland, Olav Bjerkehagen; Smoller, Jordan W.; Sonuga-Barke, Edmund J.S.; Trzaskowski, Maciej; Tsuang, Ming T.; Turecki, Gustavo; Vilar-Ribó, Laura; Vincent, John B.; Völzke, Henry; Walters, James T.R.; Weickert, Cynthia Shannon; Weickert, Thomas W.; Weissman, Myrna M. (Peer reviewed; Journal article, 2023)
      Objective: Suicidal behavior is heritable and is a major cause of death worldwide. Two large-scale genome-wide association studies (GWASs) recently discovered and cross-validated genome-wide significant (GWS) loci for ...
    • Interaction between overweight and genotypes of HLA, TCF7L2, and FTO in relation to the risk of latent autoimmune diabetes in adults and type 2 diabetes 

      Hjort, Rebecka; Löfvenborg, Josefin E.; Ahlqvist, Emma; Alfredsson, Lars; Andersson, Tomas; Grill, Valdemar Erik Robert; Groop, Leif; Sørgjerd, Elin Pettersen; Tuomi, Tiinamaija; Åsvold, Bjørn Olav; Carlsson, Sofia (Peer reviewed; Journal article, 2019)
      Objective We investigated potential interactions between body mass index (BMI) and genotypes of human leukocyte antigen (HLA), TCF7L2-rs7903146, and FTO-rs9939609 in relation to the risk of latent autoimmune diabetes in ...
    • Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset 

      Saevarsdottir, Saedis; Stefansdottir, Lilja; Sulem, Patrick; Thorleifsson, Gudmar; Ferkingstad, Egil; Rutsdottir, Gudrun; Glintborg, Bente; Westerlind, Helga; Grondal, Gerdur; Loft, Isabella C; Sorensen, Signe Bek; Lie, Benedicte Alexandra; Brink, Mikael; Arlestig, Lisbeth; Arnthorsson, Asgeir Orn; Baecklund, Eva; Banasik, Karina; Bank, Steffen; Bjorkman, Lena I; Ellingsen, Torkell; Erikstrup, Christian; Frei, Oleksandr; Gjertsson, Inger; Gudbjartsson, Daniel F; Gudjonsson, Sigurjon A; Halldorsson, Gisli H; Hendricks, Oliver; Hillert, Jan; Hogdall, Estrid; Jacobsen, Søren; Jensen, Dorte Vendelbo; Jonsson, Helgi Freyr; Kastbom, Alf; Kockum, Ingrid; Kristensen, Salome; Kristjansdottir, Helga; Larsen, Margit H; Linauskas, Asta; Hauge, Ellen-Margrethe; Loft, Anne G; Ludviksson, Bjorn R; Lund, Sigrun H; Markusson, Thorsteinn; Masson, Gisli; Melsted, Pall; Moore, Kristjan H S; Munk, Heidi; Nielsen, Kaspar R; Norddahl, Gudmundur L; Oddsson, Asmundur; Olafsdottir, Thorunn A; Olason, Pall I; Olsson, Tomas; Ostrowski, Sisse Rye; Hørslev-Petersen, Kim; Rognvaldsson, Solvi; Sanner, Helga; Silberberg, Gilad N; Stefansson, Hreinn; Sørensen, Erik; Sørensen, Inge J; Turesson, Carl; Bergman, Thomas; Alfredsson, Lars; Kvien, Tore Kristian; Brunak, Søren; Steinsson, Kristján; Andersen, Vibeke; Andreassen, Ole; Rantapää-Dahlqvist, Solbritt; Hetland, Merete Lund; Klareskog, Lars; Askling, Johan; Padyukov, Leonid; Pedersen, Ole Bv; Thorsteinsdottir, Unnur; Jonsdottir, Ingileif; Stefansson, Kari (Peer reviewed; Journal article, 2022)
      Objectives To find causal genes for rheumatoid arthritis (RA) and its seropositive (RF and/or ACPA positive) and seronegative subsets. Methods We performed a genome-wide association study (GWAS) of 31 313 RA cases (68% ...
    • Physical Activity, Genetic Susceptibility, and the Risk of Latent Autoimmune Diabetes in Adults and Type 2 Diabetes 

      Hjort, Rebecka; Ahlqvist, Emma; Andersson, Tomas; Alfredsson, Lars; Carlsson, Per-Ola; Grill, Valdemar Erik Robert; Groop, Leif; Martinell, Mats; Sørgjerd, Elin Pettersen; Tuomi, Tiinamaija; Åsvold, Bjørn Olav; Carlsson, Sofia (Peer reviewed; Journal article, 2020)
      Purpose Physical activity (PA) has been linked to a reduced risk of type 2 diabetes by reducing weight and improving insulin sensitivity. We investigated whether PA is associated with a lower incidence of latent autoimmune ...
    • The population genomic legacy of the second plague pandemic 

      Gopalakrishnan, Shyam; Ebenesersdottir, S.Sunna; Lundstrøm, Inge K.C.; Turner-Walker, Gordon; Moore, Kristjan H.S.; Luisi, Pierre; Magaryan, Ashot; Martin, Michael D.; Ellegaard, Martin Rene; Magnusson, Olafur T.; Sigurdsson, Asgeir; Snorradóttir, Steinunn; Magnúsdóttir, Droplaug N.; Laffoon, Jason E.; van Dorp, Lucy; Liu, Xiaodong; Moltke, Ida; Avila-Arcos, María C.; Schraiber, Joshua G.; Rasmussen, Simon; Juan, David; Galabert, Pere; De-Dios, Toni; Fotakis, Anna K.; Iraeta-Orbegozo, Miren; Vågene, Åshild J.; Denham, Sean Dexter; Christophersen, Axel; Stenøien, Hans K.; Vieira, Filipe G.; Liu, Shanlin; Günther, Torsten; Kivisild, Toomas; Moseng, Ole Georg; Skar, Birgitte; Cheung, Christina; Sandoval-Velasco, Marcela; Wales, Nathan; Schroeder, Hannes; Campos, Paula F.; Gudmundsdottir, Valdis B; Sicheritz - Ponten, Thomas; Petersen, Bent; Halgunset, Jostein; Gilbert, Edmund; Cavalleri, Gianpiero L.; Hovig, Eivind; Kockum, Ingrid; Olsson, Tomas; Alfredsson, Lars; Hansen, Thomas F.; Werge, Thomas; Willerslev, Eske; Balloux, Francois; Marquès-Bonet, Tomás; Lalueza-Fox, Carles; Nielsen, Rasmus; Stefánsson, Kári; Helgason, Agnar; Gilbert, Thomas P. (Peer reviewed; Journal article, 2022)
      Human populations have been shaped by catastrophes that may have left long-lasting signatures in their genomes. One notable example is the second plague pandemic that entered Europe in ca. 1,347 CE and repeatedly returned ...
    • Smoking, use of smokeless tobacco, HLA genotypes and incidence of latent autoimmune diabetes in adults 

      Edstorp, Jessica; Wei, Yuxia; Ahlqvist, Emma; Alfredsson, Lars; Grill, Valdemar Erik Robert; Groop, Leif; Rasouli, Bahareh; Sørgjerd, Elin Pettersen; Thorsby, Per Medbøe; Tuomi, Tiinamaija; Åsvold, Bjørn Olav; Carlsson, Sofia (Peer reviewed; Journal article, 2022)
      Aims/hypotheses Smoking and use of smokeless tobacco (snus) are associated with an increased risk of type 2 diabetes. We investigated whether smoking and snus use increase the risk of latent autoimmune diabetes in adults ...