• Alleviation of C⋅C Mismatches in DNA by the Escherichia coli Fpg Protein 

      Tesfahun, Almaz Nigatu; Alexeeva, Marina; Tomkuvienė, Miglė; Arshad, Aysha; Guragain, Prashanna; Klungland, Arne; Klimašauskas, Saulius; Ruoff, Peter; Bjelland, Svein (Peer reviewed; Journal article, 2021)
      DNA polymerase III mis-insertion may, where not corrected by its 3′→ 5′ exonuclease or the mismatch repair (MMR) function, result in all possible non-cognate base pairs in DNA generating base substitutions. The most ...
    • Excision of the doubly methylated base N4,5-dimethylcytosine from DNA by Escherichia coli Nei and Fpg proteins 

      Alexeeva, Marina; Guragain, Prashanna; Tesfahun, Almaz Nigatu; Tomkuvienė, Miglė; Arshad, Aysha; Gerasimaitė, Rūta; Rukšėnaitė, Audronė; Urbanavičiūtė, Giedrė; Bjørås, Magnar; Lærdahl, Jon Kristen; Klungland, Arne; Klimašauskas, Saulius; Bjelland, Svein (Journal article; Peer reviewed, 2018)
      Cytosine (C) in DNA is often modified to 5-methylcytosine (m5C) to execute important cellular functions. Despite the significance of m5C for epigenetic regulation in mammals, damage to m5C has received little attention. ...