Browsing NTNU Open by Author "Adams, Volker"
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Circulating microRNAs May Serve as Biomarkers for Hypertensive Emergency End-Organ Injuries and Address Underlying Pathways in an Animal Model
Langlo, Knut Asbjørn Rise; Silva, Gustavo Jose Justo; Overrein, Tina Syvertsen; Adams, Volker; Wisløff, Ulrik; Dalen, Håvard; Rolim, Natale Pinheiro Lage; Hallan, Stein (Journal article; Peer reviewed, 2021)There is an incomplete understanding of the underlying pathophysiology in hypertensive emergencies, where severely elevated blood pressure causes acute end-organ injuries, as opposed to the long-term manifestations of ... -
Effects of different exercise modalities on cardiac dysfunction in heart failure with preserved ejection fraction
Bode, David; Rolim, Natale Pinheiro Lage; Guthof, Tim; Hegemann, Niklas; Wakula, Paulina; Primessnig, Uwe; Berre, Anne Marie Ormbostad; Adams, Volker; Wisløff, Ulrik; Pieske, Burkert; Heinzel, Frank R.; Hohendanner, Felix (Peer reviewed; Journal article, 2021)Aims Heart failure with preserved ejection fraction (HFpEF) is an increasingly prevalent disease. Physical exercise has been shown to alter disease progression in HFpEF. We examined cardiomyocyte Ca2+ homeostasis and ... -
Exercise training reveals inflexibility of the diaphragm in an animal model of patients with obesity-driven heart failure with a preserved ejection fraction
Bowen, T Scott; Brauer, Dominic; Rolim, Natale Pinheiro Lage; Bækkerud, Fredrik Hjulstad; Kricke, Angela; Berre, Anne Marie Ormbostad; Fischer, Tina; Linke, Axel; Silva, Gustavo Jose Justo; Wisløff, Ulrik; Adams, Volker (Journal article; Peer reviewed, 2017)Background Respiratory muscle weakness contributes to exercise intolerance in patients with heart failure with a preserved ejection fraction (HFpEF)—a condition characterized by multiple comorbidities with few proven ... -
Impact of different training modalities on high-density lipoprotein function in HFpEF patients: a substudy of the OptimEx trial
Sowa, Pamela W.; Winzer, Ephraim B.; Hommel, Jennifer; Männel, Anita; van Craenenbroeck, Emeline M.; Wisløff, Ulrik; Pieske, Burkert; Halle, Martin; Linke, Axel; Adams, Volker (Peer reviewed; Journal article, 2022)Aims In heart failure with preserved ejection fraction (HFpEF), the reduction of nitric oxide (NO)-bioavailability and consequently endothelial dysfunction leads to LV stiffness and diastolic dysfunction of the heart. ... -
Iron Deficiency Impacts Diastolic Function, Aerobic Exercise Capacity, and Patient Phenotyping in Heart Failure With Preserved Ejection Fraction: A Subanalysis of the OptimEx-Clin Study
Gevaert, Andreas B.; Mueller, Stephan; Winzer, Ephraim B.; Duvinage, André; Van de Heyning, Caroline M.; Pieske-Kraigher, Elisabeth; Beckers, Paul J.; Edelmann, Frank; Wisløff, Ulrik; Pieske, Burkert; Adams, Volker; Halle, Martin; Van Craenenbroeck, Emeline M. (Peer reviewed; Journal article, 2022)Aims: Iron deficiency (ID) is linked to reduced aerobic exercise capacity and poor prognosis in patients with heart failure (HF) with reduced ejection fraction (HFrEF); however, data for HF with preserved ejection fraction ... -
Muscular changes in animal models of heart failure with preserved ejection fraction: what comes closest to the patient?
Goto, Keita; Schauer, Antje; Augstein, Antje; Methawasin, Mei; Granzier, Henk; Halle, Martin; Craenenbroeck, Emeline M Van; Rolim, Natale Pinheiro Lage; Gielen, Stephan; Pieske, Burkert; Winzer, Ephraim B.; Linke, Axel; Adams, Volker (Peer reviewed; Journal article, 2021)Aims Heart failure with preserved ejection fraction (HFpEF) is associated with reduced exercise capacity elicited by skeletal muscle (SM) alterations. Up to now, no clear medical treatment advice for HFpEF is available. ... -
Skeletal Muscle Alterations Are Exacerbated in Heart Failure With Reduced Compared With Preserved Ejection Fraction: Mediated by Circulating Cytokines?
Rolim, Natale Pinheiro Lage; Werner, Sarah; Hoshi, Tomoya; Fischer, Tina; Wisloff, Ulrik; Halle, Martin; Adams, Volker; Seiler, M; Linke, Axel; Bowen, Scott; Dieterlen, Maja-Theresa; Schuler, Gerhard; Mangner, Norman (Journal article; Peer reviewed, 2016)BACKGROUND: A greater understanding of the different underlying mechanisms between patients with heart failure with reduced (HFrEF) and with preserved (HFpEF) ejection fraction is urgently needed to better direct future ... -
Ubiquitin-proteasome-system and enzymes of energy metabolism in skeletal muscle of patients with HFpEF and HFrEF
Adams, Volker; Wunderlich, Sebastian; Mangner, Norman; Hommel, Jennifer; Esefeld, Katrin; Gielen, Stephan; Halle, Martin; Ellingsen, Øyvind; Van Craenenbroeck, Emeline M.; Wisløff, Ulrik; Pieske, Burkert; Linke, Axel; Winzer, Ephraim (Peer reviewed; Journal article, 2021)Background Skeletal muscle (SM) alterations contribute to exercise intolerance in heart failure patients with preserved (HFpEF) or reduced (HFrEF) left ventricular ejection fraction (LVEF). Protein degradation via the ...