Browsing NTNU Open by Author "Aarhus, Thomas Ihle"
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Evaluation of protective groups for purines in synthesis of CSF1R inhibitors
Bygdås, Håkon Steinholt (Master thesis, 2019)Kolonistimmulerende faktor 1 (CSF1) er ofte overuttrykt i flere typer kreft, betennelsessykdommer og beinsykdommer. Studier har vist at hemning av den kolonistimmulerende faktor 1 reseptor kinasen (CSF1R) kan gi økt effekt ... -
Negishi Cross-Coupling Reaction in the Synthesis of Benzyl Substituted Pyrrolopyrimidines as CSF-1R Inhibitors
Teksum, Vilde (Master thesis, 2020) -
Palladium Catalyzed Cross-Coupling Reactions on 7-Azaindoles in the Synthesis of CSF1R Inhibitors
Selmer-Olsen, Sigrid Maria Elisabeth (Master thesis, 2019)Overuttrykk av colony stimulating factor 1 receptor (CSF1R) tyrosin kinase er blitt linket til flere sykdommer, blant annet kreft, benosteolyse og betennelseslidelser. En lovende behandlingsstrategi for disse sykdommene ... -
Potent and selective EGFR inhibitors based on 5-aryl-7H-pyrrolopyrimidin-4-amines
Reiersølmoen, Ann Christin; Aarhus, Thomas Ihle; Eckelt, Sarah; Nørsett, Kristin Gabestad; Sundby, Eirik; Hoff, Bård Helge (Journal article; Peer reviewed, 2019)The epidermal growth factor receptor represents an important target in cancer therapy, and low molecular weight inhibitors based on quinazolines have reached the marked. Herein we report on a new scaffold, 5-aryl-7H-pyrr ... -
Synthetic strategies towards 4,6-disubstituted pyrrolo[2,3-d]pyrimidines as potential CSF-1R inhibitors
Tsui, Hay Man Hilde (Master thesis, 2019)Målet med denne masteroppgaven var å syntetisere nye 4,6-disubstituerte pyrrolo[2,3-d]pyrimidiner som hemmere for CSF-1R (”colony stimulating factor 1 receptor”) tyrosinkinase. En ny strategi for syntese av disse er også ...