Browsing NTNU Open by Journals "FEBS Open Bio"

Now showing items 1-7 of 7

    • Genetic interaction between DNA repair factors PAXX, XLF, XRCC4 and DNA-PKcs in human cells 

      Xing, Mengtan; Oksenych, Valentyn (Journal article; Peer reviewed, 2019)
      DNA double‐strand breaks (DSBs) are highly cytotoxic lesions, and unrepaired or misrepaired DSBs can lead to various human diseases, including immunodeficiency, neurological abnormalities, growth retardation, and cancer. ...

    • Halogenated boroxine increases propensity to apoptosis in leukemia (UT‐7) but not non‐tumor cells in vitro 

      Hadzic, Maida; Sun, Yitong; Tomic, Nikolina; Tsirvouli, Eirini; Kuiper, Martin; Pojskic, Lejla (Peer reviewed; Journal article, 2022)
      A hallmark of the development of solid and hematological malignancies is the dysregulation of apoptosis, which leads to an imbalance between cell proliferation, cell survival and death. Halogenated boroxine [K2(B3O3F4OH)] ...

    • Nephronectin mediates p38 MAPK‐induced cell viability via its integrin binding enhancer motif 

      Toraskar, Jimita Prashant; Magnussen, Synnøve; Chawla, Konika; Svineng, Gunbjørg; Steigedal, Tonje S. (Journal article; Peer reviewed, 2018)
      Nephronectin (NPNT) is an extracellular matrix (ECM) protein involved in kidney development. We recently reported intracellular NPNT as a potential prognostic marker in breast cancer and that NPNT promotes metastasis in ...

    • Normal development of mice lacking PAXX, the paralogue of XRCC4 and XLF 

      Gago-Fuentes, Raquel; Xing, Mengtan; Sæterstad, Siri; Sarno, Antonio; Dewan, Alisa Elinsdatter; Beck, Carole; Bradamante, Stefano; Bjørås, Magnar; Oksenych, Valentyn (Journal article; Peer reviewed, 2018)
      DNA repair consists of several cellular pathways which recognize and repair damaged DNA. The classical nonhomologous DNA end-joining (NHEJ) pathway repairs double-strand breaks in DNA. It is required for maturation of both ...

    • Robust DNA repair in PAXX-deficient mammalian cells 

      Dewan, Alisa Elinsdatter; Xing, Mengtan; Lundbæk, Marie Benner; Gago-Fuentes, Raquel; Beck, Carole; Aas, Per Arne; Liabakk, Nina-Beate; Sæterstad, Siri; Khac Thanh Phong, Chau; Kavli, Bodil Merete; Oksenych, Valentyn (Journal article; Peer reviewed, 2018)
      To ensure genome stability, mammalian cells employ several DNA repair pathways. Nonhomologous DNA end joining (NHEJ) is the DNA repair process that fixes double-strand breaks throughout the cell cycle. NHEJ is involved in ...

    • The role of PCNA as a scaffold protein in cellular signaling is functionally conserved between yeast and humans 

      Olaisen, Camilla; Kvitvang, Hans Fredrik Nyvold; Lee, Sungmin; Almaas, Eivind; Bruheim, Per; Drabløs, Finn; Otterlei, Marit (Journal article; Peer reviewed, 2018)
      Proliferating cell nuclear antigen (PCNA), a member of the highly conserved DNA sliding clamp family, is an essential protein for cellular processes including DNA replication and repair. A large number of proteins from ...

    • Uptake of circulating extracellular vesicles from rectal cancer patients and differential responses by human monocyte cultures 

      Bjørnetrø, Tonje; Steffensen, Lilly Alice; Vestad, Beate; Brusletto, Berit Sletbakk; Olstad, Ole Kristoffer; Siebke, Anne-Marie; Aass, Hans Christian Dalsbotten; Foss, Kari Bente; Llorente, Alicia; Bøe, Stig Ove; Lång, Anna Ulrika; Samiappan, Rampradeep; Redalen, Kathrine; Øvstebø, Reidun; Ree, Anne Hansen (Journal article; Peer reviewed, 2021)
      Extracellular vesicles (EVs) released by tumor cells can directly or indirectly modulate the phenotype and function of the immune cells of the microenvironment locally or at distant sites. The uptake of circulating EVs and ...