Blar i NTNU Open på forfatter "Romundstad, Pål Richard"
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Impact of the APOBEC3A/B deletion polymorphism on risk of ovarian cancer
Gansmo, Liv Beathe; Sofiyeva, Nigar; Bjørnslett, Merete Pauline; Romundstad, Pål Richard; Hveem, Kristian; Vatten, Lars Johan; Dørum, Anne; Lønning, Per Eystein; Knappskog, Stian (Journal article; Peer reviewed, 2021)A germline 29.5-kb deletion variant removes the 3’ end of the APOBEC3A gene and a large part of APOBEC3B, creating a hybrid gene that has been linked to increased APOBEC3 activity and DNA damage in human cancers. We genotyped ... -
Impacts of parasites on marine survival of Atlantic salmon: a meta-analysis
Vollset, Knut Wiik; Krontveit, Randi Ingebjørg; Jansen, Peder A; Finstad, Bengt; Barlaup, Bjørn Torgeir; Skilbrei, Ove Tommy; Krkošek, Martin; Romundstad, Pål Richard; Aunsmo, Arnfinn; Jensen, Arne Johan; Dohoo, Ian (Journal article; Peer reviewed, 2016)Parasites can, in theory, have large impacts on the survival of fish populations. One method to evaluate such impacts on anadromous species is to apply manipulative field experiments in which parallel groups of antiparasitically ... -
Influence of MDM2 SNP309 and SNP285 status on the risk of cancer in the breast, prostate, lung and colon
Gansmo, Liv Beathe; Knappskog, Stian; Romundstad, Pål Richard; Hveem, Kristian; Vatten, Lars Johan; Lønning, Per Eystein (Journal article; Peer reviewed, 2015)MDM2 is a key regulator of the p53 tumor suppressor protein and is overexpressed in many human cancers. Two single nucleotide polymorphisms (SNPs) located in the MDM2 intronic promoter (P2) have been found to exert biological ... -
Insight into the relationship between resting heart rate and atrial fibrillation: a Mendelian randomization study
Klevjer, Marie; Rasheed, Humaira; Romundstad, Pål Richard; Madssen, Erik; Brumpton, Ben Michael; Bye, Anja (Peer reviewed; Journal article, 2023)Aims A low resting heart rate (RHR) implies a more efficient heart function and a lower risk of cardiovascular disease. However, observational studies have reported a U-shaped association between RHR and atrial fibrillation ... -
Investigating the causal effect of smoking on hay fever and asthma: A Mendelian randomization meta-analysis in the CARTA consortium
Skaaby, Tea; Taylor, Amy E; Jacobsen, Rikke K.; Paternoster, Lavinia; Thuesen, Betina H.; Ahluwalia, Tarunveer S.; Larsen, Sofus C.; Zhou, Ang; Wong, Andrew; Gabrielsen, Maiken Elvestad; Bjørngaard, Johan Håkon; Flexeder, Claudia; Männistö, Satu; Hardy, Rebecca; Kuh, Diana; Barry, Sarah J.; Møllehave, Line Tang; Cerqueira, Charlotte; Friedrich, Nele; Bonten, Tobias N.; Noordam, Raymond; Mook-Kanamori, Dennis O.; Taube, Christian; Jessen, Leon E.; McConnachie, Alex; Sattar, Naveed; Upton, Mark N.; McSharry, Charles; Bønnelykke, Klaus; Bisgaard, Hans; Schulz, Holger; Strauch, Konstantin; Meitinger, Thomas; Peters, Annette; Grallert, Harald; Nohr, Ellen A.; Kivimäki, Mika; Kumari, Meena; Völker, Uwe; Nauck, Matthias; Völzke, Henry; Power, Chris; Hyppönen, Elina; Hansen, Torben; Jørgensen, Torben; Pedersen, Oluf; Salomaa, Veikko; Grarup, Niels; Langhammer, Arnulf; Romundstad, Pål Richard; Skorpen, Frank; Kaprio, Jaakko; Munafò, Marcus R.; Linneberg, Allan (Journal article; Peer reviewed, 2017)Observational studies on smoking and risk of hay fever and asthma have shown inconsistent results. However, observational studies may be biased by confounding and reverse causation. Mendelian randomization uses genetic ... -
Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium
Taylor, Amy E; Fluharty, Meg; Bjørngaard, Johan Håkon; Gabrielsen, Maiken Elvestad; Skorpen, Frank; Marioni, Riccardo R.; Campbell, A.; Engmann, J; Mirza, Saira Saeed; Loukola, A.; Laatikainen, Tiina; Partonen, Timo; Kaakinen, Marika; Ducci, Francesca; Cavadino, Alana; Husemoen, Lise Lotte N; Ahluwalia, Tarunveer Singh; Jacobsen, Rikke Kart; Skaaby, Tea; Ebstrup, Jeanette Frost; Mortensen, Erik Lykke; Minica, Camelia C; Vink, Jacqueline; Willemsen, Gonneke; Marques-Vidal, Pedro; Dale, Caroline E; Amuzu, Antoinette; Lennon, Lucy; Lahti, J; Palotie, Aarno; Räikkönen, K; Wong, Andrew; Paternoster, Lavinia; Wong, Angelita Pui-Yee; Horwood, L John; Murphy, Michael; Johnstone, Elaine; Kennedy, Martin A; Pausova, Zdenka; Paus, Tomas; Ben-Shlomo, Yoav; Nohr, Ellen A; Kuh, Diana; Kivimaki, Mika; Eriksson, Johan G; Morris, Richard W; Casas, Juan Pablo; Preisig, Martin; Boomsma, Dorret I; Linneberg, Allan; Power, Chris; Hypponen, Elina; Veijola, J; Järvelin, Marjo-Riitta; Korhonen, T.; Tiemeier, H; Kumari, Meena; Porteous, David J.; Hayward, Caroline; Romundstad, Pål Richard; Smith, George Davey; Munafo, Marcus R (Journal article; Peer reviewed, 2014)Objectives: To investigate whether associations of smoking with depression and anxiety are likely to be causal, using a Mendelian randomisation approach. Design: Mendelian randomisation meta-analyses using a genetic ... -
Is chronic non-spesific pain in adolescent girls related to early puberty?: Young-HUNT3 (2006-2008)
Kløven, Barbro (Master thesis, 2013)The main aim of this study was to assess if there was a relationship between early menarche and chronic non-specific pain in adolescents aged 13-18. We used data from the Young-HUNT3 (2006-2008) study where all adolescents ... -
Is smoking heaviness causally associated with alcohol use? A Mendelian randomization study in four European cohorts
Taylor, Michelle; Rode, Line; Bjørngaard, Johan Håkon; Taylor, Amy E.; Bojesen, Stig E.; Åsvold, Bjørn Olav; Gabrielsen, Maiken Elvestad; Lewis, Glyn; Nordestgaard, Børge G.; Romundstad, Pål Richard; Hickman, Matthew; Munafò, Marcus R. (Journal article; Peer reviewed, 2018)Background Observational studies have shown that tobacco and alcohol use co-occur, but it is not clear whether this relationship is causal. Methods Using data from the Avon Longitudinal Study of Parents and Children ... -
Is vaginal breech delivery associated with higher risk for perinatal death and cerebral palsy compared with vaginal cephalic birth? Registry-based cohort study in Norway.
Bjellmo, Solveig; Andersen, Guro Lillemoen; Martinussen, Marit; Romundstad, Pål Richard; Hjelle, Sissel; Moster, Dag; Vik, Torstein (Journal article; Peer reviewed, 2017)Objective This paper aims to study if vaginal breech delivery is associated with increased risk for neonatal mortality (NNM) or cerebral palsy (CP) in Norway where vaginal delivery accounts for 1/3 of all breech ... -
Laryngeal and Pharyngeal Squamous Cell Carcinoma After Antireflux Surgery in the 5 Nordic Countries
Yanes, Manar; Giola, Santoni; Maret-Ouda, John; Ness-Jensen, Eivind; Färkkilä, Martti A.; Lynge, Elsebeth; Pukkala, Eero; Romundstad, Pål Richard; Tryggvadottir, Laufey; von Euler-Chelpin, My; Lagergren, Jesper (Peer reviewed; Journal article, 2020)Objective: The aim of this study was to clarify whether antireflux surgery prevents laryngeal and pharyngeal squamous cell carcinoma. Summary Background Data: Gastroesophageal reflux disease (GERD) seems to increase ... -
Life Course Trajectories of Cardiovascular Risk Factors in Women With and Without Hypertensive Disorders in First Pregnancy: The HUNT Study in Norway
Haug, Eirin; Horn, Julie; Markovitz, Amanda Rose; Fraser, Abigail; Vatten, Lars Johan; Macdonald-Wallis, Corrie; Tilling, Kate; Romundstad, Pål Richard; Rich-Edwards, Janet Wilson; Åsvold, Bjørn Olav (Journal article; Peer reviewed, 2018)Background: Women with hypertensive pregnancy disorders have adverse levels of cardiovascular risk factors. It is unclear how this adverse risk factor profile evolves during adult life. We compared life course trajectories ... -
Life course trajectories of Maternal Cardiovascular Risk Factors according to Offspring Birthweight: The HUNT Study
Horn, Julie; Haug, Eirin Beate; Markovitz, Amanda R; Fraser, Abigail; Vatten, Lars Johan; Romundstad, Pål Richard; Rich-Edwards, Janet W.; Åsvold, Bjørn Olav (Peer reviewed; Journal article, 2020)Women with small or large for gestational age offspring are at increased risk of cardiovascular disease later in life. How their cardiovascular risk factors develop across the life course is incompletely known. We linked ... -
Long-term results in the treatment of lower limb occlusive disease and abdominal aortic aneurysm.
Altreuther, Martin (Doctoral theses at NTNU;2021:127, Doctoral thesis, 2021)Background: Cardiovascular disease is the most common cause of death globally, accounting for 31 % of deaths in 2016 according to WHO statistics. Arterial disease in the lower limb, and abdominal aortic aneurysm (AAA) are ... -
Longitudinal Associations between Exercise and Pain in the General Population - The HUNT Pain Study
Landmark, Tormod; Romundstad, Pål Richard; Borchgrevink, Petter Chr.; Kaasa, Stein; Dale, Ola (Journal article; Peer reviewed, 2013)Background: Population-based studies have reported conflicting findings on the relationship between physical activity and pain, and most studies reporting a relationship are cross sectional. Temporal relationships are ... -
Maternal Age at Child Birth, Birth Order, and Suicide at a Young Age: A Sibling Comparison
Bjørngaard, Johan Håkon; Bjerkeset, Ottar; Vatten, Lars Johan; Janszky, Imre; Gunnell, David; Romundstad, Pål Richard (Journal article; Peer reviewed, 2013)Previous studies have reported strong associations between birth order, maternal age, and suicide, but these results might have been confounded by socioeconomic and other factors. To control for such factors, we compared ... -
Maternal Smoking in Pregnancy and Offspring Depression: A cross cohort and negative control study
Taylor, Amy E; Carslake, David; De Mola, Christian Loret; Rydell, Mina; Nilsen, Tom Ivar Lund; Bjørngaard, Johan Håkon; Horta, Bernardo Lessa; Pearson, Rebecca; Rai, Dheeraj; Galanti, Maria Rosaria; Barros, Fernando C.; Romundstad, Pål Richard; Davey Smith, George; Munafo, Marcus R (Journal article; Peer reviewed, 2017)Previous reports suggest that offspring of mothers who smoke during pregnancy have greater risk of developing depression. However, it is unclear whether this is due to intrauterine effects. Using data from the Avon ... -
MDM2 promoter polymorphism del1518 (rs3730485) and its impact on endometrial and ovarian cancer risk
Gansmo, Liv Beathe; Bjørnslett, Merete Pauline; Halle, Mari Kyllesø; Salvesen, Helga; Romundstad, Pål Richard; Hveem, Kristian; Vatten, Lars Johan; Dørum, Anne; Lønning, Per Eystein; Knappskog, Stian (Journal article; Peer reviewed, 2017)Background The del1518 (rs3730485) polymorphism is an in/del variant in the MDM2 promoter P1. The variant is in complete linkage disequilibrium with MDM2 SNP309 (rs2279744) and has previously been found associated with ... -
MDM2 Promoter SNP344T>A (rs1196333) Status Does Not Affect Cancer Risk
Knappskog, Stian; Gansmo, Liv Beathe; Romundstad, Pål Richard; Bjørnslett, Merete Pauline; Trovik, Jone; Sommerfelt-Pettersen, Jan; Løkkevik, Erik; Tollenaar, Rob A.E.M.; Seynaeve, Caroline; Devilee, Peter; Salvesen, Helga Birgitte; Dørum, Anne; Hveem, Kristian; Vatten, Lars Johan; Lønning, Per Eystein (Journal article; Peer reviewed, 2012)The MDM2 proto-oncogene plays a key role in central cellular processes like growth control and apoptosis, and the gene locus is frequently amplified in sarcomas. Two polymorphisms located in the MDM2 promoter P2 have been ... -
MDM2 promoter SNP55 (rs2870820) affects risk of colon cancer but not breast-, lung-, or prostate cancer
Helwa, Reham; Gansmo, Liv Beathe; Romundstad, Pål Richard; Hveem, Kristian; Vatten, Lars Johan; Ryan, Bríd M.; Harris, Curtis C.; Lønning, Per Eystein; Knappskog, Stian (Journal article; Peer reviewed, 2016)Two functional SNPs (SNP285G > C; rs117039649 and SNP309T > G; rs2279744) have previously been reported to modulate Sp1 transcription factor binding to the promoter of the proto-oncogene MDM2, and to influence cancer risk. ... -
MDM4 SNP34091 (rs4245739) and its effect on breast-, colon-, lung- and prostate cancer risk.
Gansmo, Liv Beathe; Romundstad, Pål Richard; Birkeland, Einar Elvbakken; Hveem, Kristian; Vatten, Lars Johan; Knappskog, Stian; Lønning, Per Eystein (Journal article; Peer reviewed, 2015-10-16)The MDM4 protein plays an important part in the negative regulation of the tumor suppressor p53 through its interaction with MDM2. In line with this, MDM4 amplification has been observed in several tumor forms. A ...