Browsing NTNU Open by Title

Now showing items 38525-38544 of 100451

    • The genome sequence of the grey wolf, Canis lupus Linnaeus 1758 

      Sinding, Mikkel-Holger S.; Gopalakrishnan, Shyam; Raundrup, Katrine; Dalén, Love; Threlfall, Jonathan; Gilbert, Marcus Thomas Pius (Peer reviewed; Journal article, 2021)
      We present a genome assembly from an individual male Canis lupus orion (the grey wolf, subspecies: Greenland wolf; Chordata; Mammalia; Carnivora; Canidae). The genome sequence is 2,447 megabases in span. The majority of ...

    • The genome sequence of the killer whale, Orcinus orca (Linnaeus, 1758) 

      Foote, Andrew; Bunskoek, Paulien; Sanger, Wellcome (Peer reviewed; Journal article, 2022)
      We present a genome assembly from an individual female Orcinus orca (the killer whale; Chordata; Mammalia; Artiodactyla; Delphinidae). The genome sequence is 2.65 gigabases in span. The majority of the assembly (93.76%) ...

    • Genome sequencing and phylogenomic analysis of the devastating plant pathogen Phytophthora infestans 

      Niroula, Dhirendra (Master thesis, 2018)
      The oomycete P. infestans is a plant pathogen responsible for late blight of potato and tomato. This rapidly evolving pathogen is of persistent concern because of the damage it has caused since the infamous Irish famine ...

    • Genome wide association study of response to interval and continuous exercise training: the Predict-HIIT study 

      Williams, Camilla J.; Li, Zhixiu; Harvey, Nicholas; Lea, Rodney A.; Gurd, Brendon J.; Bonafiglia, Jacob T.; Papadimitriou, Ioannis; Jacques, Macsue; Croci, Ilaria; Stensvold, Dorthe; Wisløff, Ulrik; Taylor, Jenna L.; Gajanand, Trishan; Cox, Emily R.; Ramos, Joyce S.; Fassett, Robert G.; Little, Jonathan P.; Francois, Monique E.; Hearon, Christopher M.; Sarma, Satyam; Janssen, Sylvan L.J.E.; Van Craenenbroeck, Emeline M.; Beckers, Paul; Cornelissen, Véronique A.; Howden, Erin J.; Keating, Shelley E.; Yan, Xu; Bishop, David J.; Bye, Anja; Haupt, Larisa M.; Griffiths, Lyn R.; Ashton, Kevin J.; Brown, Matthew A.; Torquati, Luciana; Eynon, Nir; Coombes, Jeff S. (Peer reviewed; Journal article, 2021)
      Background Low cardiorespiratory fitness (V̇O2peak) is highly associated with chronic disease and mortality from all causes. Whilst exercise training is recommended in health guidelines to improve V̇O2peak, there is ...

    • Genome-based genetic tool development for Bacillus methanolicus: Theta-and rolling circle-replicating plasmids for inducible gene expression and application to methanol-based cadaverine production 

      Irla, Marta; Heggset, Tonje Marita Bjerkan; Nærdal, Ingemar; Paul, Lidia; Haugen, Tone; Le, Simone Balzer; Brautaset, Trygve; Wendisch, Volker F. (Peer reviewed; Journal article, 2016)
      Bacillus methanolicus is a thermophilic methylotroph able to overproduce amino acids from methanol, a substrate not used for human or animal nutrition. Based on our previous RNA-seq analysis a mannitol inducible promoter ...

    • Genome-culture coevolution drives rapid divergence in the killer whale 

      Foote, Andy; Vijay, Nagarjun; Avila-Arcos, Maria; Baird, Robin; Durban, John; Morin, Phillip; Fumagalli, Matteo; Gibbs, Richard; Hanson, Bradley; Korneliussen, Thorfinn; Martin, Michael D.; Robertson, Kelly; Sousa, Vitor; Vieira, Filipe G.; Vinar, Tomas; Wade, Paul; Worley, Kim; Excoffier, Laurent; Gilbert, M Thomas P; Wolf, Jochen B W (Journal article; Peer reviewed, 2016)
      Analysing population genomic data from killer whale ecotypes, which we estimate have globally radiated within less than 250,000 years, we show that genetic structuring including the segregation of potentially functional ...

    • Genome-level transcription data of Yersinia pestis analyzed with a New metabolic constraint-based approach 

      Navid, Ali; Almaas, Eivind (Journal article; Peer reviewed, 2012)
      Background: Constraint-based computational approaches, such as flux balance analysis (FBA), have proven successful in modeling genome-level metabolic behavior for conditions where a set of simple cellular objectives can ...

    • Genome-resolved metagenomics suggests a mutualistic relationship between Mycoplasma and salmonid hosts 

      Rasmussen, Jacob A.; Villumsen, Kasper Rømer; Duchêne, David; Puetz, Lara; Delmont, Tom; Sveier, Harald; von Gersdorff Jørgensen, Louise; Præbel, Kim; Martin, Michael David; Bojesen, Anders Miki; Gilbert, Marcus Thomas Pius; Kristiansen, Karsten; Limborg, Morten T. (Peer reviewed; Journal article, 2021)
      Salmonids are important sources of protein for a large proportion of the human population. Mycoplasma species are a major constituent of the gut microbiota of salmonids, often representing the majority of microbiota. Despite ...

    • Genome-scale cold stress response regulatory networks in ten Arabidopsis thaliana ecotypes 

      Barah, Pankaj; Doni, Jayavelu Naresh; Rasmussen, Simon; Nielsen, Henrik Bjørn; Mundy, John; Bones, Atle M. (Journal article; Peer reviewed, 2013)
      Background Low temperature leads to major crop losses every year. Although several studies have been conducted focusing on diversity of cold tolerance level in multiple phenotypically divergent Arabidopsis thaliana (A. ...

    • Genome-scale constraint-based metabolic modeling and analysis of Nannochloropsis Sp. 

      Pham, Nhung (Master thesis, 2016)
      Genome scale metabolic models provide a link between genomic and metabolic information. The constraint-based approach is increasingly important for quantitatively analyzing the essential aspects of metabolic pathways, for ...

    • Genome-scale metabolic modelling when changes in environmental conditions affect biomass composition 

      Schulz, Christian; Kumelj, Tjasa; Karlsen, Emil; Almaas, Eivind (Peer reviewed; Journal article, 2021)
      Genome-scale metabolic modeling is an important tool in the study of metabolism by enhancing the collation of knowledge, interpretation of data, and prediction of metabolic capabilities. A frequent assumption in the use ...

    • Genome-scale metabolic models reveal determinants of phenotypic differences in non-Saccharomyces yeasts 

      Pettersen, Jakob Peder; Castillo, Sandra; Jouhten, Paula; Almaas, Eivind (Peer reviewed; Journal article, 2023)
      Background - Use of alternative non-Saccharomyces yeasts in wine and beer brewing has gained more attention the recent years. This is both due to the desire to obtain a wider variety of flavours in the product and to reduce ...

    • Genome-Scale Modeling of Embryonic Stem Cells 

      Nyhamar, Kristen (Master thesis, 2023)
      Genom-skala metabolisk modellering har nylig blitt et sentralt verktøy innen bioteknologi. I denne masteroppgaven er målet å bruke rammeverket sMOMENT til å kombinere omics-data med en genom-skala metabolisk rekonstruksjon ...

    • Genome-scale models and consequences of mass constraints and availability of enzymes 

      Kumelj, Tjasa (Doctoral theses at NTNU;2021:294, Doctoral thesis, 2021)
      Genome-scale metabolic reconstructions offer a system-level view of metabolic networks with genetic basis and suggest mechanistic determination of cell's physiological homeostatic states. Consequently, they offer the ability ...

    • Genome-scale reconstructions to assess metabolic phylogeny and organism clustering 

      Schulz, Christian; Almaas, Eivind (Peer reviewed; Journal article, 2020)
      Approaches for systematizing information of relatedness between organisms is important in biology. Phylogenetic analyses based on sets of highly conserved genes are currently the basis for the Tree of Life. Genome-scale ...

    • Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions 

      Khoury, Samar; Parisien, Marc; Thompson, Scott J.; Vachon-Presseau, Etienne; Roy, Mathieu; Mitchell, Amy; Winsvold, Bendik K S; Skogholt, Anne Heidi; Brumpton, Ben Michael; Willer, Cristen J.; Fors, Egil Andreas; Heuch, Ingrid; Nielsen, Jonas Bille; Storheim, Kjersti; Hagen, Knut; Nilsen, Kristian Bernhard; Hveem, Kristian; Fritsche, Lars; Thomas, Laurent; Pedersen, Linda Margareth; Gabrielsen, Maiken Elvestad; Johnsen, Marianne Bakke; Lie, Marie; Holmen, Oddgeir; Børte, Sigrid; Stensland, Synne; Zhou, Wei; Mundal, Ingunn Pernille; Zwart, John Anker Henrik; Kania, Artur; Mogil, Jeffrey S.; Diatchenko, Luda (Peer reviewed; Journal article, 2021)
      Chronic pain is often present at more than one anatomical location, leading to chronic overlapping pain conditions (COPC). Whether COPC represents a distinct pathophysiology from the occurrence of pain at only one site is ...

    • Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles 

      Hautakangas, Heidi; Winsvold, Bendik K S; Ruotsalainen, Sanni; Bjornsdottir, Gyda; Harder, Aster V. E.; Kogelman, Lisette J. A.; Thomas, Laurent; Noordam, Raymond; Benner, Christian; Gormley, Padhraig; Artto, Ville; Banasik, Karina; Bjornsdottir, Anna; Boomsma, Dorret I.; Brumpton, Ben Michael; Burgdorf, Kristoffer Sølvsten; Buring, Julie E.; Chalmer, Mona Ameri; de Boer, Irene; Dichgans, Martin; Erikstrup, Christian; Färkkilä, Markus; Gabrielsen, Maiken Elvestad; Ghanbari, Mohsen; Hagen, Knut; Häppölä, Paavo; Hottenga, Jouke-Jan; Hrafnsdottir, Maria G.; Hveem, Kristian; Johnsen, Marianne Bakke; Kähönen, Mika; Kristoffersen, Espen Saxhaug; Kurth, Tobias; Lehtimäki, Terho; Lighart, Lannie; Magnusson, Sigurdur H.; Malik, Rainer; Pedersen, Ole Birger; Pelzer, Nadine; Penninx, Brenda W. J. H.; Ran, Caroline; Ridker, Paul M.; Rosendaal, Frits Richard; Sigurdardottir, Gudrun R.; Skogholt, Anne Heidi; Sveinsson, Olafur A.; Thorgeirsson, Thorgeir E.; Ullum, Henrik; Zwart, John Anker Henrik (Peer reviewed; Journal article, 2022)
      Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Here, we performed a genome-wide association study of 102,084 migraine cases and 771,257 controls and identified ...

    • Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders 

      Eijsbouts, Chris; Skogholt, Anne Heidi; Ness-Jensen, Eivind; Hveem, Kristian (Peer reviewed; Journal article, 2021)
      Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for ...

    • Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease 

      Zheng, Thenghao; Skogholt, Anne Heidi; Gabrielsen, Maiken Elvestad; Hveem, Kristian; Thomas, Laurent; Ness-Jensen, Eivind (Peer reviewed; Journal article, 2021)
      Objective Haemorrhoidal disease (HEM) affects a large and silently suffering fraction of the population but its aetiology, including suspected genetic predisposition, is poorly understood. We report the first genome-wide ...

    • Genome-wide analysis of the oxyntic proliferative isthmus zone reveals ASPM as a possible gastric stem/progenitor cell marker overexpressed in cancer. 

      Vange, Pål; Bruland, Torunn; Beisvag, Vidar; Erlandsen, Sten Even; Flatberg, Arnar; Doseth, Berit; Sandvik, Arne Kristian; Bakke, Ingunn (Journal article; Peer reviewed, 2015)
      The oxyntic proliferative isthmus zone contains the main stem/progenitor cells that provide for physiological renewal of the distinct mature cell lineages in the oxyntic epithelium of the stomach. These cells are also ...