• How do 66 European institutional review boards approve one protocol for an international prospective observational study on traumatic brain injury? Experiences from the CENTER-TBI study 

      Timmers, Marjolein; van Dijck, Jeroen T. J. M.; van Wijk, Roel P J; Legrand, Valerie; van Veen, Ernest; Maas, Andrew I.R.; Menon, David K; Citerio, Giuseppe; Stocchetti, Nino; Kompanje, Erwin J.O.; Andelic, Nada; Andreassen, Lasse; Anke, Audny; Frisvold, Shirin; Helseth, Eirik; Røe, Cecilie; Røise, Olav; Skandsen, Toril; Vik, Anne; Åkerlund, Cecilia; Amrein, Krisztina; Antoni, Anna; Audibert, Gerard; Azouvi, Philippe; Azzolini, Maria Luisa; Bartels, Ronald; Barzo, Pal; Beauvais, Romuald; Beer, Ronny; Bellander, Bo-Michael; Belli, Antonio; Benali, Habib; Berardino, Maurizio; Beretta, Luigi; Blaabjerg, Morten; Bragge, Peter; Brazinova, Alexandra; Brinck, Vibeke; Brooker, Joanne; Brorsson, Camilla; Buki, Andras; Bullinger, Monika; Cabeleira, Manuel; Caccioppola, Alessio; Calappi, Emiliana; Calvi, Maria Rosa; Cameron, Peter; Lozano, Guillermo Carbayo; Carbonara, Marco; Cavallo, Simona (Peer reviewed; Journal article, 2020)
      Bakgrunn Den europeiske unionen (EU) har som mål å optimalisere pasientbeskyttelse og effektivitet i helseforskningen ved å harmonisere prosedyrer i alle medlemsstater. Likevel kreves ytterligere forbedringer for å øke ...
    • Improving assessment quality in professional higher education: Could external peer review be the answer? 

      Smeby, Susanne Skjervold; Lillebo, Børge; Gynnild, Vidar; Samstad, Eivind; Standal, Rune; Knobel, Heidi; Vik, Anne; Slørdahl, Tobias Schmidt (Journal article; Peer reviewed, 2019)
      Summative assessment in professional higher education is important for student learning and making sound decisions about advancement and certification. Despite rigorous pre-test quality assurance procedures, problematic ...
    • Incidence of mild traumatic brain injury: A prospective hospital, emergency room and general practitioner-based study 

      Skandsen, Toril; Nilsen, Tom Ivar Lund; Einarsen, Cathrine Elisabeth; Normann, Ingunn; McDonagh, David; Håberg, Asta; Vik, Anne (Peer reviewed; Journal article, 2019)
      Background: There are no recent estimates of incidence rates of mild traumatic brain injury (MTBI) from Norway. Moreover, reported incidence rates rarely comprise cases of MTBI evaluated in the primary care setting. In ...
    • Life after adolescent and adult moderate and severe traumatic brain injury: self-reported executive, emotional, and behavioural function 2-5 years after injury 

      Finnanger, Torun Gangaune; Olsen, Alexander; Skandsen, Toril; Lydersen, Stian; Vik, Anne; Evensen, Kari A. Indredavik; Catroppa, Cathy; Håberg, Asta; Andersson, Stein; Indredavik, Marit Sæbø (Peer reviewed; Journal article, 2015)
      Survivors of moderate-severe Traumatic Brain Injury (TBI) are at risk for long-term cognitive, emotional, and behaviouralproblems. This prospective cohort study investigated self-reported executive, emotional, and behavioural ...
    • Machine learning algorithms performed no better than regression models for prognostication in traumatic brain injury 

      Gravesteijn, BY; Nieboer, Daan; Ercole, Ari; Lingsma, Hester F; Nelson, David; Van Calster, Ben; Steyerberg, Ewout W; Andelic, Nada; Anke, Audny; Frisvold, Shirin; Helseth, Eirik; Røe, Cecilie; Røise, Olav; Skandsen, Toril; Vik, Anne (Peer reviewed; Journal article, 2020)
      Objective We aimed to explore the added value of common machine learning (ML) algorithms for prediction of outcome for moderate and severe traumatic brain injury. Study Design and Setting We performed logistic regression ...
    • Mild and Moderate Traumatic Brain Injury: Epidemiology, Imaging and Outcome 

      Einarsen, Cathrine Elisabeth (Doctoral theses at NTNU;2019:264, Doctoral thesis, 2019)
      Lett og moderat traumatisk hjerneskade: Epidemiologi, bildediagnostikk og utkomme Traumatisk hjerneskade er en av de viktigste årsakene til død og nedsatt funksjon blant yngre voksne i høyinntekstland, og antall tilfeller ...
    • Moderate traumatic brain injury - the acute phase 

      Lund, Stine Borgen (Master thesis, 2012)
      Background and aim: Patients with moderate traumatic brain injury (TBI) have variability in the acute phase course and long-term outcome. Research is limited and often inconclusive. The aim was to study intensive care ...
    • Moderate traumatic brain injury, acute phase course and deviations in physiological variables: an observational study 

      Lund, Stine Borgen; Gjeilo, Kari Hanne; Moen, Kent Gøran; Schirmer-Mikalsen, Kari; Skandsen, Toril; Vik, Anne (Journal article; Peer reviewed, 2016)
      Background: Patients with moderate traumatic brain injury (TBI) are a heterogeneous group with great variability in clinical course. Guidelines for monitoring and level of care in the acute phase are lacking. The main ...
    • Moderate traumatic brain injury: Clinical characteristics and a prognostic model of 12-month outcome 

      Einarsen, Cathrine Elisabeth; van der Naalt, Joukje; Jacobs, Bram; Follestad, Turid; Moen, Kent Gøran; Vik, Anne; Håberg, Asta; Skandsen, Toril (Journal article; Peer reviewed, 2018)
      BACKGROUND:Patients with moderate traumatic braininjury (TBI) often are studied together with patients withsevere TBI, even though the expected outcome of theformer is better. Therefore, we aimed to describe patientcharacteristics ...
    • Patients with mild traumatic brain injury recruited from both hospital and primary care settings: A controlled longitudinal magnetic resonance imaging study 

      Einarsen, Cathrine Elisabeth; Moen, Kent Gøran; Håberg, Asta; Eikenes, Live; Kvistad, Kjell Arne; Xu, Jian; Moe, Hans Kristian; Hexeberg, Marie; Vik, Anne; Skandsen, Toril (Journal article; Peer reviewed, 2019)
      With an emphasis on traumatic axonal injury (TAI), frequency and evolution of traumatic intracranial lesions on 3T clinical magnetic resonance imaging (MRI) were assessed in a combined hospital and community-based study ...
    • Patients with moderate and severe traumatic brain injury: impact of preinjury platelet inhibitor or warfarin treatment 

      Hexeberg, Marie; Vik, Anne; Skandsen, Toril; Sandrød, Oddrun; Deane, Susan Frances; Rao, Vidar; Moen, Kent Gøran (Journal article; Peer reviewed, 2018)
      Objective We aimed to examine the effect of preinjury antithrombotic medication on clinical and radiologic neuroworsening in traumatic brain injury (TBI) and study the effect on outcome. Methods A total of 184 consecutive ...
    • Post-Concussion Symptoms in Complicated vs. Uncomplicated Mild Traumatic Brain Injury Patients at Three and Six Months Post-Injury: Results from the CENTER-TBI Study 

      Voomolen, DC; Haagsma, JA; Polinder, Suzanne; Maas, AIR; Steyerberg, Ewout W; Vulekovic, Peter; Sewalt, CA; Gravesteijn, BY; Covic, Amra; Andelic, Nada; Plass, AM; von Steinbüchel, Nicole; Vik, Anne; Andreassen, Lasse; Anke, Audny; Frisvold, Shirin Kordasti; Helseth, Eirik; Skandsen, Toril; Røise, Olav; Håberg, Asta; Røe, Cecilie (Journal article; Peer reviewed, 2019)
      Abstract The aim of this study was to assess the occurrence of post-concussion symptoms and post-concussion syndrome (PCS) in a large cohort of patients after complicated and uncomplicated mild traumatic brain injury (mTBI) ...
    • Prediction of Global Functional Outcome and Post-Concussive Symptoms after Mild Traumatic Brain Injury: External Validation of Prognostic Models in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study 

      Mikolic, Ana; Polinder, Suzanne; Steyerberg, Ewout W; Retel Helmrich, Isabel; Giacino, Joseph T.; Maas, Andrew I.R.; van der Naalt, Joukje; Voormolen, Daphne; von Steinbüchel, Nicole; Wilson, Lindsay; Lingsma, Hester F; van Klaveren, David; Andelic, Nada; Andreassen, Lasse; Anke, Audny; Frisvold, Shirin; Helseth, Eirik; Røe, Cecilie; Røise, Olav; Skandsen, Toril; Vik, Anne; Åkerlund, Cecilia; Amrein, Krisztina; Antoni, Anna; Audibert, Gerard; Azouvi, Philippe; Azzolini, Maria Luisa; Bartels, Ronald; Barzo, Pal; Beauvais, Romuald; Beer, Ronny; Bellander, Bo-Michael; Belli, Antonio; Benali, Habib; Berardino, Maurizio; Beretta, Luigi; Blaabjerg, Morten; Bragge, Peter; Brazinova, Alexandra; Brinck, Vibeke; Brooker, Joanne; Brorsson, Camilla; Buki, Andras; Bullinger, Monika; Cabeleira, Manuel; Caccioppola, Alessio; Calappi, Emiliana; Calvi, Maria Rosa; Cameron, Peter; Lozano, Guillermo Carbayo; Carbonara, Marco (Peer reviewed; Journal article, 2020)
      The majority of traumatic brain injuries (TBIs) are categorized as mild, according to a baseline Glasgow Coma Scale (GCS) score of 13–15. Prognostic models that were developed to predict functional outcome and persistent ...
    • Prehospital Management of Traumatic Brain Injury across Europe: A CENTER-TBI Study 

      Gravesteijn, BY; Sewalt, Charlie; Stocchetti, Nino; Citerio, Giuseppe; Ercole, Ari; Lingsma, Hester F; Von Steinbuchel, Nicole; Steyerberg, Ewout W; Wilson, Lindsay; Maas, Andrew I.R.; Menon, David K; Lecky, Fiona E.; Andelic, Nada; Andreassen, Lasse; Anke, Audny; Frisvold, Shirin; Helseth, Eirik; Røe, Cecilie; Røise, Olav; Skandsen, Toril; Vik, Anne; Åkerlund, Cecilia; Amrein, Krisztina; Antoni, Anna; Audibert, Gerard; Azouvi, Philippe; Azzolini, Maria Luisa; Bartels, Ronald; Barzo, Pal; Beauvais, Romuald; Beer, Ronny; Bellander, Bo-Michael; Belli, Antonio; Benali, Habib; Berardino, Maurizio; Beretta, Luigi; Blaabjerg, Morten; Bragge, Peter; Brazinova, Alexandra; Brinck, Vibeke; Brooker, Joanne; Brorsson, Camilla; Buki, Andras; Bullinger, Monika; Cabeleira, Manuel; Caccioppola, Alessio; Calappi, Emiliana; Calvi, Maria Rosa; Cameron, Peter; Lozano, Guillermo Carbayo; Carbonara, Marco; Cavallo, Simona; Chevallard, Giorgio; Chieregato, Arturo (Peer reviewed; Journal article, 2020)
      Background: Prehospital care for traumatic brain injury (TBI) is important to prevent secondary brain injury. We aim to compare prehospital care systems within Europe and investigate the association of system characteristics ...
    • Prospective longitudinal MRI study of brain volumes and diffusion changes during the first year after moderate to severe traumatic brain injury 

      Brezova, Veronika; Moen, Kent Gøran; Skandsen, Toril; Vik, Anne; Brewer, James B.; Salvesen, Øyvind; Håberg, Asta (Journal article, 2014)
      The objectives of this prospective study in 62 moderate–severe TBI patients were to investigate volume change in cortical gray matter (GM), hippocampus, lenticular nucleus, lobar white matter (WM), brainstem and ventricles ...
    • Quality indicators for patients with traumatic brain injury in European intensive care units: a CENTER-TBI study 

      Huijben, Jilske A.; Wiegers, E; Ercole, Ari; de Keizer, Nicolette; Maas, Andrew I. R.; Steyerberg, Ewout W.; Citerio, Giuseppe; Wilson, Lindsay; Polinder, Suzanne; Nieboer, Daan; Menon, David; Lingsma, Hester F.; Van Der Jagt, Mathieu; Andelic, Nada; Lund, Stine Borgen; Frisvold, Shirin; Helseth, Eirik; Røe, Cecilie; Røise, Olav; Schirmer-Mikalsen, Kari; Vik, Anne (Peer reviewed; Journal article, 2020)
      Background The aim of this study is to validate a previously published consensus-based quality indicator set for the management of patients with traumatic brain injury (TBI) at intensive care units (ICUs) in Europe and ...
    • Recruitment bias in mild traumatic brain injury research. Description of patients with mild traumatic brain injury not included for research in a single centre in Norway 

      Normann, Ingunn (Master thesis, 2016)
      Study aim: The aim of this study was to give a description of demographic and injury variables of the patients who were not included in the mild traumatic brain injury (TBI) study at St. Olav´s Hospital. Methods: All ...
    • Risk Factors for Unruptured Intracranial Aneurysms and Subarachnoid Hemorrhage in a Prospective Population-Based Study 

      Müller, Tomm Brostrup; Vik, Anne; Romundstad, Pål Richard; Sandvei, Marie Søfteland (Journal article; Peer reviewed, 2019)
      Background and Purpose— We wanted to evaluate potential risk factors for unruptured intracranial aneurysms (UIAs) and aneurysmal subarachnoid hemorrhage (aSAH) in a large, prospective study of the general population with ...
    • Severe traumatic brain injury in Norway: impact of age on outcome 

      Røe, Cecilie; Skandsen, Toril; Anke, Audny; Ader, Tiina; Vik, Anne; Lund, Stine Borgen; Manskow, Unn Sollid; Sollid, Snorre; Sundstrøm, Terje; Hestnes, Morten; Andelic, Nada (Journal article; Peer reviewed, 2013)
      Objective: The aim of this study was to investigate the influence of age on mortality and 3-month outcome in a Norwegian cohort of patients with severe traumatic brain injury (TBI). Methods: Norwegian residents ≥ 16 years ...
    • Systemic inflammation persists the first year after mild traumatic brain injury: Results from the Prospective Trondheim Mild Traumatic Brain Injury Study 

      Chaban, Viktoriia; Clarke, Gerard; Skandsen, Toril; Islam, Rakibul; Einarsen, Cathrine Elisabeth; Vik, Anne; Damås, Jan Kristian; Mollnes, Tom Eirik; Håberg, Asta; Pischke, Soeren (Peer reviewed; Journal article, 2020)
      Innate immune activation has been attributed a key role in traumatic brain injury (TBI) and successive morbidity. In mild TBI (mTBI), however, the extent and persistence of innate immune activation are unknown. We determined ...