Blar i NTNU Open på forfatter "Tessem, May-Britt"
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Metabolic effects of ultraviolet radiation on the anterior part of the eye
Tessem, May-Britt (Doktoravhandlinger ved NTNU, 1503-8181; 2006:22, Doctoral thesis, 2006)Ultraviolet radiation (UV-R) is an environmental factor known to increase the risk of developing an irreversible opacification of the lens (cataract). Increased irradiance of UV-R to the earth because of depletion of ... -
Molecular biomarkers of prostate cancer
Hansen, Ailin Falkmo (Doctoral theses at NTNU;2017:337, Doctoral thesis, 2017) -
Multi-Level Molecular Characterisation of Prostate Cancer
Sandsmark, Elise (Doctoral theses at NTNU;2017:174, Doctoral thesis, 2017)Prostate cancer is the most common malignancy in Norwegian men, and represents a substantial health burden. The disease is heterogeneous, ranging from slow growing and indolent, to very aggressive and lethal. One of the ... -
Multi-omics molecular profiling of prostate cancer
Andersen, Maria K. (Doctoral theses at NTNU;2019:59, Doctoral thesis, 2019)Prostate cancer is the most common form of malignancy inflicting men in the west and manifests itself as a heterogeneous disease with a range of different clinical outcomes. Whereas some prostate tumors grow slowly and ... -
NMR-based metabolomics of biofluids in cancer
Giskeødegård, Guro F.; Madssen, Torfinn Støve; Euceda, Leslie R.; Tessem, May-Britt; Moestue, Siver Andreas; Bathen, Tone Frost (Journal article; Peer reviewed, 2018)Metabolomics is the branch of “omics” technologies that involves high‐throughput identification and quantification of small‐molecule metabolites in the metabolome. NMR‐based spectroscopy of biofluids represents a potential ... -
NMR-Based Prostate Cancer Metabolomics
Euceda, Leslie R.; Andersen, Maria Karoline; Tessem, May-Britt; Moestue, Siver Andreas; Grinde, Maria Tunset; Bathen, Tone Frost (Journal article; Peer reviewed, 2018)Prostate cancer is the second most common malignancy, and the fifth leading cause of cancer-related death among men, worldwide. A major unsolved clinical challenge in prostate cancer is the ability to accurately distinguish ... -
An optimized MALDI MSI protocol for spatial detection of tryptic peptides in fresh frozen prostate tissue
Høiem, Therese Stork; Andersen, Maria Karoline; Martin-Lorenzo, Marta; Longuespée, Rémi; Claes, Britt S.R.; Nordborg, Anna; Dewez, Frédéric; Balluff, Benjamin; Giampà , Marco; Sharma, Animesh; Hagen, Lars; Heeren, Ron M.A.; Bathen, Tone Frost; Giskeødegård, Guro F.; Krossa, Sebastian; Tessem, May-Britt (Peer reviewed; Journal article, 2022)MALDI MS imaging (MSI) is a powerful analytical tool for spatial peptide detection in heterogeneous tissues. Proper sample preparation is crucial to achieve high quality, reproducible measurements. Here we developed an ... -
Prediction of recurrence from metabolites and expression of TOP2A and EZH2 in prostate cancer patients treated with radiotherapy
Hansen, Ailin Falkmo; Høiem, Therese Stork; Selnæs, Kirsten Margrete; Bofin, Anna M.; Størkersen, Øystein; Bertilsson, Helena; Wright, Alan J.; Giskeødegård, Guro F.; Bathen, Tone Frost; Rye, Morten Beck; Tessem, May-Britt (Peer reviewed; Journal article, 2023)Background The dual upregulation of TOP2A and EZH2 gene expression has been proposed as a biomarker for recurrence in prostate cancer patients to be treated with radical prostatectomy. A low tissue level of the metabolite ... -
Presence of TMPRSS2-ERG is associated with alterations of the metabolic profile in human prostate cancer
Hansen, Ailin Falkmo; Sandsmark, Elise; Rye, Morten Beck; Wright, Alan J; Bertilsson, Helena; Richardsen, Elin; Viset, Trond; Bofin, Anna M.; Angelsen, Anders; Selnæs, Kirsten Margrete; Bathen, Tone Frost; Tessem, May-Britt (Journal article; Peer reviewed, 2016)TMPRSS2-ERG has been proposed to be a prognostic marker for prostate cancer. The aim of this study was to identify changes in metabolism, genes and biochemical recurrence related to TMPRSS2-ERG by using an integrated ... -
SFRP4 gene expression is increased in aggressive prostate cancer
Sandsmark, Elise; Andersen, Maria Karoline; Bofin, Anna M.; Bertilsson, Helena; Drabløs, Finn; Bathen, Tone Frost; Rye, Morten Beck; Tessem, May-Britt (Journal article; Peer reviewed, 2017)Increased knowledge of the molecular differences between indolent and aggressive prostate cancer is needed for improved risk stratification and treatment selection. Secreted frizzled-related protein 4 (SFRP4) is a modulator ... -
A simple preparation protocol for shipping and storage of tissue sections for laser ablation-inductively coupled plasma-mass spectrometry imaging
Buchholz, Rebecca; Krossa, Sebastian; Andersen, Maria Karoline; Holtkamp, Michael; Sperling, Michael; Karst, Uwe; Tessem, May-Britt (Peer reviewed; Journal article, 2022)A rapid and cost-efficient tissue preparation protocol for laser ablation-inductively coupled plasma-mass spectrometry imaging (LA–ICP–MSI) has been developed within this study as an alternative to the current gold standard ... -
Simultaneous Detection of Zinc and Its Pathway Metabolites Using MALDI MS Imaging of Prostate Tissue
Andersen, Maria Karoline; Krossa, Sebastian; Høiem, Therese Stork; Buchholz, Rebecca; Claes, Britt S.R.; Balluff, Benjamin; Ellis, Shane; Richardsen, Elin; Bertilsson, Helena; Heeren, Ron M.A.; Bathen, Tone Frost; Karst, Uwe; Giskeødegård, Guro F.; Tessem, May-Britt (Journal article; Peer reviewed, 2020)Levels of zinc, along with its mechanistically related metabolites citrateand aspartate, are widely reported as reduced in prostate cancer compared to healthytissue and are therefore pointed out as potential cancer biomarkers. ... -
Spatial differentiation of metabolism in prostate cancer tissue by MALDI-TOF MSI
Andersen, Maria Karoline; Høiem, Therese Stork; Claes, Britt S.R.; Balluff, Benjamin; Marta, Martin-Lorenzo; Richardsen, Elin; Krossa, Sebastian; Bertilsson, Helena; Heeren, Ron M.A.; Rye, Morten Beck; Giskeødegård, Guro F.; Bathen, Tone Frost; Tessem, May-Britt (Peer reviewed; Journal article, 2021)Background Prostate cancer tissues are inherently heterogeneous, which presents a challenge for metabolic profiling using traditional bulk analysis methods that produce an averaged profile. The aim of this study was ... -
Spermine and Citrate as Metabolic Biomarkers for Assessing Prostate Cancer Aggressiveness
Giskeødegård, Guro F.; Bertilsson, Helena; Selnæs, Kirsten Margrete; Wright, A.J.; Bathen, Tone Frost; Viset, Trond; Halgunset, Jostein; Angelsen, Anders; Gribbestad, Ingrid S; Tessem, May-Britt (Journal article; Peer reviewed, 2013)Separating indolent from aggressive prostate cancer is an important clinical challenge for identifying patients eligible for active surveillance, thereby reducing the risk of overtreatment. The purpose of this study was ... -
The effect of sampling procedures and day-to-day variations in metabolomics studies of biofluids
Giskeødegård, Guro F.; Andreassen, Trygve; Bertilsson, Helena; Tessem, May-Britt; Bathen, Tone Frost (Journal article; Peer reviewed, 2019)Metabolomics analysis of biofluids is a feasible tool for disease characterization and monitoring due to its minimally invasive nature. To reduce unwanted variation in biobanks and clinical studies, it is important to ... -
Tissue microstructure is linked to MRI parameters and metabolite levels in prostate cancer
Selnæs, Kirsten Margrete; Vettukattil, Muhammad Riyas; Bertilsson, Helena; Wright, Alan J.; Heerschap, Arend; Angelsen, Anders; Tessem, May-Britt; Bathen, Tone Frost (Peer reviewed; Journal article, 2016)Introduction: Magnetic resonance imaging (MRI) can portray spatial variations in tumor heterogeneity, architecture, and its microenvironment in a non-destructive way. The objective of this study was to assess the relationship ...