Browsing NTNU Open by Author "Selbæk, Geir"
Now showing items 21-40 of 49
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Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci
Witoelar, Aree; Rongve, Arvid; Almdahl, Ina Selseth; Ulstein, Ingun; Engvig, Andreas; White, Linda Rosemary; Selbæk, Geir; Stordal, Eystein; Andersen, Fredrik; Brækhus, Anne; Saltvedt, Ingvild; Engedal, Knut; Hughes, Timothy; Bergh, Sverre; Bråthen, Geir; Bogdanovic, Nenad; Bettella, Francesco; Wang, Yunpeng; Athanasiu, Lavinia; Bahrami, Shahram; Le Hellard, Stephanie; Giddaluru, Sudheer; Dale, Anders M; Sando, Sigrid Botne; Steinberg, Stacy; Stefansson, Hreinn; Snaedal, Jon; Desikan, Rahul S; Stefansson, Kari; Aarsland, Dag; Djurovic, Srdjan; Fladby, Tormod; Andreassen, Ole Andreas (Journal article; Peer reviewed, 2018)A large fraction of genetic risk factors for Alzheimer’s Disease (AD) is still not identified, limiting the understanding of AD pathology and study of therapeutic targets. We conducted a genome-wide association study (GWAS) ... -
Midlife Physical Activity, Psychological Distress, and Dementia Risk: The HUNT Study
Zotcheva, Ekaterina; Bergh, Sverre; Selbæk, Geir; Krokstad, Steinar; Håberg, Asta; Strand, Bjørn Heine; Ernstsen, Linda (Journal article; Peer reviewed, 2018)Background: Physical activity (PA) is associated with a decreased dementia risk, whereas psychological distress (distress) is linked to an increased dementia risk. Objective: We investigated independent and joint ... -
Mobility and cognition at admission to the nursing home – a cross-sectional study
Sverdrup, Karen; Bergh, Sverre; Selbæk, Geir; Røen, Irene Mari; Kirkevold, Øyvind; Tangen, Gro Gujord (Journal article; Peer reviewed, 2018)Background Earlier studies show that the main reasons for admission to long-term nursing home care are cognitive impairment and functional impairments of activities of daily life. However, descriptive evidence of mobility ... -
Modifiable factors affecting older patients' quality of life and physical function during cancer treatment
Kirkhus, Lene; Harneshaug, Magnus; Saltyte Benth, Jurate; Grønberg, Bjørn Henning; Rostoft, Siri; Bergh, Sverre; Hjermstad, Marianne Jensen; Selbæk, Geir; Wyller, Torgeir Bruun; Kirkevold, Øyvind; Borza, Tom; Saltvedt, Ingvild; Jordhøy, Marit Slaaen (Journal article; Peer reviewed, 2019)Background Maintaining physical function and quality of life (QoL) are prioritized outcomes among older adults. We aimed to identify potentially modifiable factors affecting older patients' physical function and QoL ... -
Mortality in older adults with frequent alcohol consumption and use of drugs with addiction potential – The Nord Trøndelag Health Study 2006-2008 (HUNT3), Norway, a population-based study
Tevik, Kjerstin Elisabeth; Selbæk, Geir; Engedal, Knut; Seim, Arnfinn; Krokstad, Steinar; Helvik, Anne-Sofie (Journal article; Peer reviewed, 2019)Background The aim of this study was to investigate whether frequent drinking, use of drugs with addiction potential and the possible combination of frequent drinking and use of prescribed drugs with addiction potential ... -
MRI-assessed atrophy subtypes in Alzheimer’s disease and the cognitive reserve hypothesis
Persson, Karin; Eldholm, Rannveig Sakshaug; Barca, Maria Lage; Cavallin, Lena; Ferreira, Daniel; Knapskog, Anne Brita; Selbæk, Geir; Brækhus, Anne; Saltvedt, Ingvild; Westman, Eric; Engedal, Knut (Journal article; Peer reviewed, 2017)Background/Aims MRI assessment of the brain has demonstrated four different patterns of atrophy in patients with Alzheimer’s disease dementia (AD): typical AD, limbic-predominant AD, hippocampal-sparing AD, and a subtype ... -
MRI-based classification models in prediction of mild cognitive impairment and dementia in late-life depression
Lebedeva, Aleksandra K.; Westman, Eric; Borza, Tom; Beyer, Mona K.; Engedal, Knut; Aarsland, Dag; Selbæk, Geir; Håberg, Asta (Journal article; Peer reviewed, 2017)Objective: Late-life depression (LLD) is associated with development of different types of dementia. Identification of LLD patients, who will develop cognitive decline, i.e., the early stage of dementia would help to ... -
Multi-psychotropic drug prescription and the association to neuropsychiatric symptoms in three Norwegian nursing home cohorts between 2004 and 2011
Gulla, Christine; Selbæk, Geir; Flo, Elisabeth; Kjome, Reidun Lisbet Skeide; Kirkevold, Øyvind; Husebø, Bettina (Journal article; Peer reviewed, 2016)Background Neuropsychiatric symptoms, such as affective symptoms, psychosis, agitation, and apathy are common among nursing home patients with and without dementia. Treatment with one or more psychotropic drug is often ... -
Nursing home admission during the first year after hospitalization - The contribution of cognitive impairment
Helvik, Anne-Sofie; Skancke, Randi H.; Selbæk, Geir; Engedal, Knut (Journal article; Peer reviewed, 2014)Objective: The importance of cognitive and physical functioning for nursing home admission among medically hospitalized older patients is rarely studied in a one-year follow-up perspective. This study aims to explore ... -
Persistent use of psychotropic drugs in nursing home residents in Norway
Helvik, Anne-Sofie; Saltyte Benth, Jurate; Wu, Bei; Engedal, Knut; Selbæk, Geir (Journal article; Peer reviewed, 2017)Background The prevalence of psychotropic drug (PTD) use in NH residents is high, but few have explored prevalence and persistency in PTD in NH residents and factors associated with persistency. This at the same time as ... -
Physical diagnoses in nursing home residents - is dementia or severity of dementia of importance?
Jørgensen, Live Bredholt; Thorleifsson, Berit Marie; Selbæk, Geir; Saltyte Benth, Jurate; Helvik, Anne-Sofie (Journal article; Peer reviewed, 2018)Background Dementia and physical morbidity are primary reasons for nursing home admission globally. However, data on physical morbidity in nursing home residents with and without dementia are scarce. The first aim of the ... -
Predictors for Nursing Home Admission and Death among Community-Dwelling People 70 Years and Older Who Receive Domiciliary Care
Wergeland, Jon Normann; Selbæk, Geir; Bergh, Sverre; Söderhamn, Ulrika; Kirkevold, Øyvind (Journal article; Peer reviewed, 2015)Aim: The aim of this study was to analyze which variables predicted nursing home admission (NHA) and death. Methods: 1,001 recipients of domiciliary care were assessed three times in a 3-year period. Through bivariate and ... -
Progression of Alzheimer's Disease: A Longitudinal Study in Norwegian Memory Clinics
Eldholm, Rannveig Sakshaug; Barca, Maria Lage; Persson, Karin; Knapskog, Anne-Brita; Kersten, Hege; Engedal, Knut; Selbæk, Geir; Brækhus, Anne; Skovlund, Eva; Saltvedt, Ingvild (Journal article; Peer reviewed, 2017)Background: The course of Alzheimer’s disease (AD) varies considerably between individuals. There is limited evidence on factors important for disease progression. Objective: The primary aim was to study the progression ... -
Resource Use and Disease Course in dementia - Nursing Home (REDIC-NH), a longitudinal cohort study; design and patient characteristics at admission to Norwegian nursing homes
Røen, Irene Mari; Selbæk, Geir; Kirkevold, Øyvind; Engedal, Knut; Testad, Ingelin; Bergh, Sverre (Journal article; Peer reviewed, 2017)Background Earlier studies of nursing home patients show a high prevalence of dementia, neuropsychiatric symptoms (NPS), pain, and dependency in activities of daily living. The REDIC-NH cohort was set up to study the disease ... -
Sense of coherence and quality of life in older in-hospital patients without cognitive impairment- a 12 month follow-up study
Helvik, Anne-Sofie; Engedal, Knut; Selbæk, Geir (Journal article; Peer reviewed, 2014)Background The relation between sense of coherence (SOC) and quality of life (QoL) among older persons has been found in some, but not all, studies and mostly in studies with cross-sectional design. We wanted to study if ... -
Severity of Neuropsychiatric Symptoms in Nursing Home Residents
Helvik, Anne-Sofie; Engedal, Knut; Wu, Bei; Saltyte Benth, Jurate; Corazzini, Kirsten; Røen, Irene Mari; Selbæk, Geir (Journal article; Peer reviewed, 2016)We aimed at assessing time shift in the severity of neuropsychiatric symptoms (NPS) in nursing home residents between 2004/2005 and 2010/2011 and associations between NPS and socio-demographic variables, physical health ... -
Targeted interdisciplinary model for evaluation and treatment of neuropsychiatric symptoms : a cluster randomized controlled trial
Lichtwarck, Bjørn; Selbæk, Geir; Kirkevold, Øyvind; Rokstad, Anne Marie Mork; Saltyte Benth, Jurate; Lindstrøm, Jonas Christoffer; Bergh, Sverre (Journal article; Peer reviewed, 2017)Objective To determine the effectiveness of the Targeted Interdisciplinary Model for Evaluation and Treatment of Neuropsychiatric Symptoms (TIME) for treatment of moderate to severe agitation in people with dementia. Methods ... -
Temporal changes in cardiorespiratory fitness and risk of dementia incidence and mortality: a population-based prospective cohort study
Tari, Atefe R; Nauman, Javaid; Zisko, Nina; Skjellegrind, Håvard; Bosnes, Ingunn; Bergh, Sverre; Stensvold, Dorthe; Selbæk, Geir; Wisløff, Ulrik (Journal article; Peer reviewed, 2019)Cardiorespiratory fitness is associated with risk of dementia, but whether temporal changes in cardiorespiratory fitness influence the risk of dementia incidence and mortality is still unknown. We aimed to study whether ... -
The Agreement between the MMSE and IQCODE Tests in a Community-Based Sample of Subjects Aged 70 Years or Older Receiving In-Home Nursing: An Explorative Study
Kirkevold, Øyvind; Selbæk, Geir (Peer reviewed; Journal article, 2015)Aim: It was the aim of this study to compare the Mini-Mental State Examination (MMSE) with the Informant Questionnaire for Cognitive Decline in the Elderly (IQCODE) and to explore the characteristics of subjects with ... -
The course of neuropsychiatric symptoms in nursing home residents from admission to 30-month follow-up
Helvik, Anne-Sofie; Selbæk, Geir; Saltyte Benth, Jurate; Røen, Irene Mari; Bergh, Sverre (Journal article; Peer reviewed, 2018)Aim The aim of this study was to describe the prevalence and persistence of clinically significant neuropsychiatric symptoms (NPS) in nursing home residents with dementia, and to study the association between severity of ...