Browsing NTNU Open by Author "Sandvig, Axel"
Now showing items 21-40 of 51
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Increased cost of living - Network scale motor neuron dysfunction in amyotrophic lateral sclerosis
Fiskum, Vegard (Doctoral theses at NTNU;2023:263, Doctoral thesis, 2023)Amyotrofisk lateral sklerose (ALS) er en progressiv nevrodegenerativ sykdom som påvirker motornevroner i det sentrale nervesystemet. Det er den tredje mest vanlige nevrodegenerative sykdommen, med 2 tilfeller per 100 000 ... -
Inhibiting the neuronal region with initial neurodegeneration: effects on neuropathology and behavior
Ebbesen, Nora Cecilie (Master thesis, 2021)Alzheimers sykdom er nevrodegenerativ og progressiv, og den vanligste årsaken til demens. Til tross for at Alzheimers er en økende global helse- og sosioøkonomisk bekymring, er ingen effektiv kur eller behandling tilgjengelig. ... -
The inside-out of Alzheimer’s disease
Bjørkli, Christiana Lucinda (Doctoral theses at NTNU;2022:222, Doctoral thesis, 2022)Every three seconds someone is diagnosed with dementia, and Alzheimer’s disease (AD) constitutes most of these cases. In the absence of a cure for AD, testing hypotheses regarding disease onset and spread, and developing ... -
Isolation and comparison of neural stem cells from the adult rat brain and spinal cord canonical neurogenic niches
Schiro, Lars Erik; Bauer, Ulrich Stefan; Sandvig, Axel; Sandvig, Ioanna (Peer reviewed; Journal article, 2022)Here, we present a unified protocol for the extraction, culture, and basic characterization of rat neural stem cells (NSCs) from all three canonical neurogenic niches in the brain and spinal cord. We describe tissue ... -
L-DOPA-Coated Manganese Oxide Nanoparticles as Dual MRI Contrast Agents and Drug-Delivery Vehicles
McDonagh, Birgitte Hjelmeland; Singh, Gurvinder; Hak, Sjoerd; Bandyopadhyay, Sulalit; Augestad, Ingrid Lovise; Peddis, Davide; Sandvig, Ioanna; Sandvig, Axel; Glomm, Wilhelm (Journal article; Peer reviewed, 2016)Manganese oxide nanoparticles (MONPs) are capable of time-dependent magnetic resonance imaging contrast switching as well as releasing a surface-bound drug. MONPs give T2/T2* contrast, but dissolve and release T1-active ... -
Labelling of olfactory ensheathing cells with micron-sized particles of iron oxide and detection by MRI
Sandvig, Ioanna; Hoang, Linh; Sardella, Thomas CP; Barnett, SC; Brekken, Christian; Tvedt, Kåre; Berry, Martin; Haraldseth, Olav; Sandvig, Axel; Thuen, Marte (Journal article; Peer reviewed, 2012)A crucial issue in transplant‐mediated repair of the damaged central nervous system (CNS) is serial non‐invasive imaging of the transplanted cells, which has led to interest in the application of magnetic resonance imaging ... -
Method to Obtain Neuromorphic Reservoir Networks from Images of in Vitro Cortical Networks
Mello, Gustavo; Pontes-Filho, Sidney; Sandvig, Ioanna; Valderhaug, Vibeke Devold; Zouganeli, Evi; Huse Ramstad, Ola; Sandvig, Axel; Nichele, Stefano (Chapter, 2020)In the brain, the structure of a network of neurons defines how these neurons implement the computations that underlie the mind and the behavior of animals and humans. Provided that we can describe the network of neurons ... -
Micro- and mesoscale neuroplasticity of in vitro cortical neuronal networks
Bie, Rikke (Master thesis, 2020)Bakgrunn: Aksonskade er et kjennetegn ved traumatiske skader tilført sentralnervesystemet (CNS). Pasienter lider ofte av langvarige funksjonsnedsettelser som et resultat av den komplekse patofysiologien assosiert med slike ... -
Model-Free All-Source-All-Destination Learning as a Model for Biological Reactive Control
Knudsen, Martinius; Hendseth, Sverre; Tufte, Gunnar; Sandvig, Axel (Journal article; Peer reviewed, 2021)We present here a model-free method for learning actions that lead to an all-source-all-destination shortest path solution. We motivate our approach in the context of biological learning for reactive control. Our method ... -
Model-free Control of Partially Observable Underactuated Systems by pairing Reinforcement Learning with Delay Embeddings
Knudsen, Martinius; Hendseth, Sverre; Tufte, Gunnar; Sandvig, Axel (Peer reviewed; Journal article, 2022)Abstract: Partial observability is a problem in control design where the measured states are insufficient in describing the systems trajectory. Interesting real-world systems often exhibit nonlinear behavior and noisy, ... -
Motifs of Order: Emergent Self-Organization and Complex Dynamics in Biological Neural Networks
Weir, Janelle Shari (Doctoral theses at NTNU;2024:37, Doctoral thesis, 2024) -
Nanoparticle delivery to the brain - By focused ultrasound and self-assembled nanoparticle-stabilized microbubbles
Åslund, Andreas; Berg, Sigrid; Hak, Sjoerd; Mørch, Ýrr Asbjørg; Torp, Sverre Helge; Sandvig, Axel; Widerøe, Marius; Hansen, Rune; Davies, Ruth Catharina de Lange (Journal article, 2015)The blood–brain barrier (BBB) constitutes a significant obstacle for the delivery of drugs into the central nervous system (CNS). Nanoparticles have been able to partly overcome this obstacle and can thus improve drug ... -
Nanoparticle Mediated P-Glycoprotein Silencing for Improved Drug Delivery across the Blood-Brain Barrier: A siRNA-Chitosan Approach
Malmo, Jostein; Sandvig, Axel; Vårum, Kjell Morten; Strand, Sabina P. (Journal article; Peer reviewed, 2013)Background: Neonatal intermittent hyperoxia-hypoxia (IHH) is involved in the pathogenesis of retinopathy of prematurity. Whether similar oxygen fluctuations will create pathological changes in the grey and white matter ... -
Neural disorder at the edge of chaos
Ramstad, Ola Huse (Doctoral theses at NTNU;2020:288, Doctoral thesis, 2020) -
Neuronal avalanche dynamics and functional connectivity elucidate information propagation in vitro
Heiney, Kristine Anne; Huse Ramstad, Ola; Fiskum, Vegard; Sandvig, Axel; Sandvig, Ioanna; Nichele, Stefano (Peer reviewed; Journal article, 2022)Cascading activity is commonly observed in complex dynamical systems, including networks of biological neurons, and how these cascades spread through the system is reliant on how the elements of the system are connected ... -
Neuroplasticity in stroke recovery. The role of microglia in engaging and modifying synapses and networks
Sandvig, Ioanna; Augestad, Ingrid Lovise; Håberg, Asta; Sandvig, Axel (Journal article; Peer reviewed, 2018)Neuroplasticity after ischaemic injury involves both spontaneous rewiring of neural networks and circuits as well as functional responses in neurogenic niches. These events involve complex interactions with activated ... -
Selective inhibition of excitatory synaptic transmission alters the emergent bursting dynamics of in vitro neural networks
Weir, Janelle Shari; Christiansen, Nicholas; Sandvig, Axel; Sandvig, Ioanna (Journal article; Peer reviewed, 2023) -
Self-organized Criticality in engineered in vitro networks; A balance of excitation and inhibition
Jordbræk, Sondre valentin (Master thesis, 2021)The emergence of critical dynamics has been associated with the balance of excitation to inhibition (E/I). The aim of this thesis was to explore the relationship of E/I balance with emergence of critical dynamics, stability ... -
Silencing of activity during hypoxia improves functional outcomes in motor neuron networks in vitro
Fiskum, Vegard; Sandvig, Axel; Sandvig, Ioanna (Peer reviewed; Journal article, 2021)The effects of hypoxia, or reduced oxygen supply, to brain tissue can be disastrous, leading to extensive loss of function. Deoxygenated tissue becomes unable to maintain healthy metabolism, which leads to increased ... -
Smart and Multifunctional Core-Shell Nanoparticles (NPs) for Drug Delivery
Bandyopadhyay, Sulalit (Doctoral theses at NTNU;2016:294, Doctoral thesis, 2016)Nanomaterials designed for drug delivery applications require important properties that include monodispersity, biocompatibility, long circulation time which are dependent on size, shape, composition, surface charge among ...