Blar i NTNU Open på forfatter "Oksenych, Valentyn"
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Low temperature and low UV indexes correlated with peaks of influenza virus activity in Northern Europe during 2010-2018
Ianevski, Aleksandr; Zusinaite, Eva; Shtaida, Nastassia; Kallio-Kokko, Hannimari; Valkonen, Mia; Kantele, Anu; Telling, Kaidi; Lutsar, Irja; Letjuka, Pille; Metelitsa, Natalja; Oksenych, Valentyn; Dumpis, Uga; Vitkauskiene, Astra; Stašaitis, Kestutis; Öhrmalm, Christina; Bondeson, Kåre; Bergqvist, Anders; Cox, Rebecca Jane; Tenson, Tanel; Merits, Andres; Kainov, Denis (Journal article; Peer reviewed, 2019)With the increasing pace of global warming, it is important to understand the role of meteorological factors in influenza virus (IV) epidemics. In this study, we investigated the impact of temperature, UV index, humidity, ... -
Mediator of DNA Damage Checkpoint Protein 1 Facilitates V(D)J Recombination in Cells Lacking DNA Repair Factor XLF
Beck, Carole; Castaneda Zegarra, Sergio Miguel; Huse, Camilla; Xing, Mengtan; Oksenych, Valentyn (Journal article; Peer reviewed, 2020)DNA double-strand breaks (DSBs) trigger the Ataxia telangiectasia mutated (ATM)-dependent DNA damage response (DDR), which consists of histone H2AX, MDC1, RNF168, 53BP1, PTIP, RIF1, Rev7, and Shieldin. Early stages of B ... -
Metformin Therapy Changes Gut Microbiota Alpha-Diversity in COVID-19 Patients with Type 2 Diabetes: The Role of SARS-CoV-2 Variants and Antibiotic Treatment
Petakh, Pavlo; Kamyshna, Iryna; Oksenych, Valentyn; Kainov, Denis; Kamyshnyi, Aleksandr (Peer reviewed; Journal article, 2023)The gut microbiota play a crucial role in maintaining host health and have a significant impact on human health and disease. In this study, we investigated the alpha diversity of gut microbiota in COVID-19 patients and ... -
Mono- and combinational drug therapies for global viral pandemic preparedness
Ianevski, Aleksandr; Yao, Rouan; Simonsen, Ronja Meyer; Myhre, Vegard; Ravlo, Erlend; Kaynova, Gerda D.; Zusinaite, Eva; White, Judith M.; Polyak, Stephen J.; Oksenych, Valentyn; Windisch, Marc P.; Pan, Qiuwei; Lastauskienė, Eglė; Vitkauskienė, Astra; Matukevičius, Algimantas; Tenson, Tanel; Bjørås, Magnar; Kainov, Denis (Peer reviewed; Journal article, 2022)Broadly effective antiviral therapies must be developed to be ready for clinical trials, which should begin soon after the emergence of new life-threatening viruses. Here, we pave the way towards this goal by reviewing ... -
Nafamostat–interferon-α combination suppresses sars-cov-2 infection in vitro and in vivo by cooperatively targeting host TMPRSS2
Ianevski, Aleksandr; Yao, Rouan; Lysvand, Hilde; Grødeland, Gunnveig; Legrand, Nicolas; Oksenych, Valentyn; Zusinaite, Eva; Tenson, Tanel; Bjørås, Magnar; Kainov, Denis E. (Peer reviewed; Journal article, 2021)SARS-CoV-2 and its vaccine/immune-escaping variants continue to pose a serious threat to public health due to a paucity of effective, rapidly deployable, and widely available treatments. Here, we address these challenges ... -
Non-Homologous End Joining Factors XLF, PAXX and DNA-PKcs Maintain the Neural Stem and Progenitor Cell Population
Gago-Fuentes, Raquel; Oksenych, Valentyn (Peer reviewed; Journal article, 2020)Non-homologous end-joining (NHEJ) is a major DNA repair pathway in mammalian cells that recognizes, processes and fixes DNA damage throughout the cell cycle and is specifically important for homeostasis of post-mitotic ... -
Normal development of mice lacking PAXX, the paralogue of XRCC4 and XLF
Gago-Fuentes, Raquel; Xing, Mengtan; Sæterstad, Siri; Sarno, Antonio; Dewan, Alisa Elinsdatter; Beck, Carole; Bradamante, Stefano; Bjørås, Magnar; Oksenych, Valentyn (Journal article; Peer reviewed, 2018)DNA repair consists of several cellular pathways which recognize and repair damaged DNA. The classical nonhomologous DNA end-joining (NHEJ) pathway repairs double-strand breaks in DNA. It is required for maturation of both ... -
Novel Synergistic Anti-Enteroviral Drug Combinations
Ianevski, Aleksandr; Zusinaite, Eva; Tenson, Tanel; Oksenych, Valentyn; Wang, Wei; Afset, Jan Egil; Bjørås, Magnar; Kainov, Denis (Peer reviewed; Journal article, 2022)Background: Enterovirus infections affect people around the world, causing a range of illnesses, from mild fevers to severe, potentially fatal conditions. There are no approved treatments for enterovirus infections. Methods: ... -
Potential Antiviral Options against SARS-CoV-2 Infection. Viruses.
Ianevski, Aleksandr; Yao, Rouan; Fenstad, Mona H.; Biza, Svetlana; Zusinaite, Eva; Reisberg, Tuuli; Lysvand, Hilde; Løseth, Kirsti; Landsem, Veslemøy Malm; Fossum, Janne; Erlandsen, Sten Even; Aas, Per Arne; Hagen, Lars; Pettersen, Caroline Hild; Tenson, Tanel; Afset, Jan Egil; Nordbø, Svein Arne; Bjørås, Magnar; Kainov, Denis; Oksenych, Valentyn (Peer reviewed; Journal article, 2020)As of June 2020, the number of people infected with severe acute respiratory coronavirus 2 (SARS-CoV-2) continues to skyrocket, with more than 6.7 million cases worldwide. Both the World Health Organization (WHO) and United ... -
Robust DNA repair in PAXX-deficient mammalian cells
Dewan, Alisa Elinsdatter; Xing, Mengtan; Lundbæk, Marie Benner; Gago-Fuentes, Raquel; Beck, Carole; Aas, Per Arne; Liabakk, Nina-Beate; Sæterstad, Siri; Khac Thanh Phong, Chau; Kavli, Bodil Merete; Oksenych, Valentyn (Journal article; Peer reviewed, 2018)To ensure genome stability, mammalian cells employ several DNA repair pathways. Nonhomologous DNA end joining (NHEJ) is the DNA repair process that fixes double-strand breaks throughout the cell cycle. NHEJ is involved in ... -
Role of GCN5 and PCAF in the B Lymphocyte Development
Chau, Khac Thanh Phong (Master thesis, 2018)DNA in our cells is constantly damage by internal and external factors generating DSBs. To maintain genome stability, cells have developed various DNA damage surveillance and repair mechanisms to prevent chromosomal ... -
Role of GCN5 and PCAF in the B Lymphocyte Development
Chau, Khac Thanh Phong (Master thesis, 2018)DNA in our cells is constantly damage by internal and external factors generating DSBs. To maintain genome stability, cells have developed various DNA damage surveillance and repair mechanisms to prevent chromosomal ... -
Synergistic interferon-alpha-based combinations for treatment of sars-cov-2 and other viral infections
Ianevski, Aleksandr; Yao, Rouan; Zusinaite, Eva; Lello, Laura Sandra; Wang, Sainan; Jo, Eunji; Yang, Jaewon; Ravlo, Erlend; Wang, Wei; Lysvand, Hilde; Løseth, Kirsti; Oksenych, Valentyn; Tenson, Tanel; Windisch, Marc P.; Poranen, Minna M.; Nieminen, Anni I.; Nordbø, Svein Arne; Fenstad, Mona H.; Grødeland, Gunnveig; Aukrust, Pål; Trøseid, Marius; Kantele, Anu; Lastauskienė, Eglė; Vitkauskienė, Astra; Legrand, Nicolas; Merits, Andres; Bjørås, Magnar; Kainov, Denis (Journal article; Peer reviewed, 2021)Background: There is an urgent need for new antivirals with powerful therapeutic potential and tolerable side effects. Methods: Here, we tested the antiviral properties of interferons (IFNs), alone and with other drugs in ... -
Synthetic lethality between DNA repair factors Xlf and Paxx is rescued by inactivation of Trp53
Castañeda-Zegarra, Sergio; Xing, Mengtan; Gago-Fuentes, Raquel; Sæterstad, Siri; Oksenych, Valentyn (Journal article; Peer reviewed, 2019)Non-homologous end joining (NHEJ) is a DNA repair pathway that senses, processes and ligates DNA double-strand breaks (DSBs) throughout the cell cycle. During NHEJ, core Ku70 and Ku80 subunits bind DSBs as a heterodimer ... -
Synthetic lethality between murine DNA repair factors XLF and DNA-PKcs is rescued by inactivation of Ku70
Xing, Mengtan; Bjørås, Magnar; Daniel, Jeremy A.; Alt, Frederick W.; Oksenych, Valentyn (Journal article; Peer reviewed, 2017)DNA double-strand breaks (DSBs) are recognized and repaired by the Classical Non-Homologous End-Joining (C-NHEJ) and Homologous Recombination pathways. C-NHEJ includes the core Ku70 and Ku80 (or Ku86) heterodimer that binds ... -
Therapeutic Effectiveness of Interferon-α2b against COVID-19 with Community-Acquired Pneumonia: The Ukrainian Experience
Kamyshnyi, Aleksandr; Koval, Halyna; Kobevko, Olha; Buchynskyi, Mykhailo; Oksenych, Valentyn; Kaynov, Denis; Lyubomirskaya, Katerina; Kamyshna, Iryna; Potters, Geert; Moshynets, Olena (Peer reviewed; Journal article, 2023)Despite several targeted antiviral drugs against SARS-CoV-2 currently being available, the application of type I interferons (IFNs) still deserves attention as an alternative antiviral strategy. This study aimed to assess ... -
Tyrosine Kinase Inhibitors Target B Lymphocytes
Esnardo Upfold, Nikki Lyn; Petakh, Pavlo; Kamyshnyi, Aleksandr; Oksenych, Valentyn (Peer reviewed; Journal article, 2023)Autoimmune disorders and some types of blood cancer originate when B lymphocytes malfunction. In particular, when B cells produce antibodies recognizing the body’s proteins, it leads to various autoimmune disorders. ...